2-{2-[(4-methylbenzyl)oxy]phenoxy}acetaldehyde | 870724-57-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-{2-[(4-methylbenzyl)oxy]phenoxy}acetaldehyde
• 英文别名: 2-[2-[(4-Methylphenyl)methoxy]phenoxy]acetaldehyde
• CAS: 870724-57-5
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: YCPQUKZFPACLPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-{2-[(4-methylbenzyl)oxy]phenoxy}acetaldehyde 、 2-((2,6-二甲氧基苯基)氧基)乙胺 在 盐酸 、 4 A molecular sieve 、 sodium cyanoborohydride 作用下， 以 乙醇 为溶剂， 以42%的产率得到N-[2-(2,6-dimethoxyphenoxy)ethyl]-2-[2-[(4-methylphenyl)methoxy]phenoxy]ethanamine
  参考文献：
  名称：

  Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 8. {2-[2-(4-Chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (Clopenphendioxan) as a Tool to Highlight the Involvement of α_1D- and α_1B-Adrenoreceptor Subtypes in the Regulation of Human PC-3 Prostate Cancer Cell Apoptosis and Proliferation

  摘要：

  A series of new alpha(1)-adrenoreceptor antagonists (5-18) was prepared by introducing various substituents (Topliss approach) into the ortho, meta, and para positions of the benzyloxy function of the phendioxan open analogue 4 ("openphendioxan"). All the compounds synthesized were potent antagonists and generally displayed, similarly to 4, the highest affinity values at alpha(1D)-with respect to alpha(1A)- and alpha(1B)-AR subtypes and 5-HT1A subtype. By sulforhodamine B (SRB) assay on human PC-3 prostate cancer cells, the new compounds showed antitumor activity (estimated on the basis of three parameters GI(50), TGI, LC50), at low micromolar concentration, with 7 ("clopenphendioxan") exhibiting the highest efficacy. Moreover, this study highlighted for the first time alpha(1D)- and alpha(1B)-AR expression in PC3 cells and also demonstrated the involvement of these subtypes in the modulation of apoptosis and cell proliferation. A significant reduction of alpha(1D)- and alpha(1B)-AR expression in PC3 cells was associated with the apoptosis induced by 7. This depletion was completely reversed by norepinephrine.

  DOI：

  10.1021/jm0580398
• 作为产物：
  描述：

  2-苯甲氧基苯酚 在 palladium on activated charcoal 盐酸 、 氢气 、 sodium hydride 、 potassium carbonate 、 溶剂黄146 作用下， 以 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 20.0~125.0 ℃ 、344.74 kPa 条件下， 反应 13.5h， 生成 2-{2-[(4-methylbenzyl)oxy]phenoxy}acetaldehyde
  参考文献：
  名称：

  Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 8. {2-[2-(4-Chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (Clopenphendioxan) as a Tool to Highlight the Involvement of α_1D- and α_1B-Adrenoreceptor Subtypes in the Regulation of Human PC-3 Prostate Cancer Cell Apoptosis and Proliferation

  摘要：

  A series of new alpha(1)-adrenoreceptor antagonists (5-18) was prepared by introducing various substituents (Topliss approach) into the ortho, meta, and para positions of the benzyloxy function of the phendioxan open analogue 4 ("openphendioxan"). All the compounds synthesized were potent antagonists and generally displayed, similarly to 4, the highest affinity values at alpha(1D)-with respect to alpha(1A)- and alpha(1B)-AR subtypes and 5-HT1A subtype. By sulforhodamine B (SRB) assay on human PC-3 prostate cancer cells, the new compounds showed antitumor activity (estimated on the basis of three parameters GI(50), TGI, LC50), at low micromolar concentration, with 7 ("clopenphendioxan") exhibiting the highest efficacy. Moreover, this study highlighted for the first time alpha(1D)- and alpha(1B)-AR expression in PC3 cells and also demonstrated the involvement of these subtypes in the modulation of apoptosis and cell proliferation. A significant reduction of alpha(1D)- and alpha(1B)-AR expression in PC3 cells was associated with the apoptosis induced by 7. This depletion was completely reversed by norepinephrine.

  DOI：

  10.1021/jm0580398

文献信息

• Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 8. {2-[2-(4-Chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (Clopenphendioxan) as a Tool to Highlight the Involvement of α_1D- and α_1B-Adrenoreceptor Subtypes in the Regulation of Human PC-3 Prostate Cancer Cell Apoptosis and Proliferation
  作者：Wilma Quaglia、Giorgio Santoni、Maria Pigini、Alessandro Piergentili、Francesco Gentili、Michela Buccioni、Michela Mosca、Roberta Lucciarini、Consuelo Amantini、Massimo Ivan Nabissi、Patrizia Ballarini、Elena Poggesi、Amedeo Leonardi、Mario Giannella

  DOI：10.1021/jm0580398

  日期：2005.12.1

  A series of new alpha(1)-adrenoreceptor antagonists (5-18) was prepared by introducing various substituents (Topliss approach) into the ortho, meta, and para positions of the benzyloxy function of the phendioxan open analogue 4 ("openphendioxan"). All the compounds synthesized were potent antagonists and generally displayed, similarly to 4, the highest affinity values at alpha(1D)-with respect to alpha(1A)- and alpha(1B)-AR subtypes and 5-HT1A subtype. By sulforhodamine B (SRB) assay on human PC-3 prostate cancer cells, the new compounds showed antitumor activity (estimated on the basis of three parameters GI(50), TGI, LC50), at low micromolar concentration, with 7 ("clopenphendioxan") exhibiting the highest efficacy. Moreover, this study highlighted for the first time alpha(1D)- and alpha(1B)-AR expression in PC3 cells and also demonstrated the involvement of these subtypes in the modulation of apoptosis and cell proliferation. A significant reduction of alpha(1D)- and alpha(1B)-AR expression in PC3 cells was associated with the apoptosis induced by 7. This depletion was completely reversed by norepinephrine.