3-(3-ethoxy-phenyl)-acrylic acid ethyl ester | 24393-57-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(3-ethoxy-phenyl)-acrylic acid ethyl ester
• 英文别名: ethyl (E)-3-(3-ethoxypenyl)-2-propenoate；3-ethoxy-trans-cinnamic acid ethyl ester；3-Aethoxy-trans-zimtsaeure-aethylester；trans-3-Aethoxy-zimtsaeure-aethylester；Ethyl trans-3-ethoxycinnamate；ethyl (E)-3-(3-ethoxyphenyl)prop-2-enoate
• CAS: 24393-57-5
• 化学式: C₁₃H₁₆O₃
• mdl: MFCD02683511
• 分子量: 220.268
• InChiKey: HCKOJKUUNSOANP-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.307
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(3-ethoxy-phenyl)-acrylic acid ethyl ester 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 3-(3-ethoxy-phenyl)-propionic acid ethyl ester
  参考文献：
  名称：

  Isocytosine H2-receptor histamine antagonists I. Oxmetidine and related compounds

  摘要：

  DOI：

  10.1016/0223-5234(88)90167-5
• 作为产物：
  描述：

  反-3-乙氧基肉桂酸 在 硫酸 、 甲苯 作用下， 生成 3-(3-ethoxy-phenyl)-acrylic acid ethyl ester
  参考文献：
  名称：

  Peak et al., Journal of the Chemical Society, 1936, p. 752,755

  摘要：

  DOI：

文献信息

• One-Pot Conversion of Allyl Alcohols into Selenochroman Derivatives.
  作者：Hitoshi ABE、Akira YAMASAKI、Natsuko KOSHIBA、Yasuo TAKEUCHI、Takashi HARAYAMA

  DOI：10.1248/cpb.49.1223

  日期：——

  A one-pot conversion of allyl alcohols into selenochroman derivatives was achieved by treatment with a phenyl trimethylsilyl selenide (TMSSePh)-AlBr3 reagent system.

  通过苯基三甲基硅硒 (TMSSePh)-AlBr3 试剂体系的处理，实现了烯丙基醇向硒铬衍生物的单锅转化。
• Anxiolytic and anti-depressant thienopyridine derivatives
  申请人：BEECHAM GROUP PLC

  公开号：EP0126970A2

  公开（公告）日：1984-12-05

  Compounds of formula (I) and pharmaceutically acceptable salts thereof: wherein: G together with the two carbon atoms to which it is bonded is a thieno moiety; R, is phenyl optionally substituted by one or more C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, hydroxy, C2-7 alkanoyl, halo, trifuluoromethyl, nitro, amino optionally substituted by one or two C1-6 alkyl groups or by C2- 7 alkanoyl, cyano, carbamoyl or carboxy groups; or pyridyl optionally substituted by C1-6 alkyl or halo; R6 is hydrogen, c1-6 alkyl or phenyl optionally substituted as defined hereinbefore for R1 when phenyl; R8 is hydrogen, one of the optional substituents recited hereinbefore for R, when phenyl or phenyl optionally substituted as defined hereinbefore for R, when phenyl; and either R2 is hydrogen, or C1-6 alkyl optionally substituted by hydroxy, amino disubstituted by C1-6 alkyl, or phenyl optionally substituted as defined hereinbefore for R, when phenyl; R3 and R4 together represent a bond; R5 and R7 together represent a bond; and R9 is hydrogen and R10 is hydroxy, C1-6 alkoxy or amino optionally substituted by one or two independently selected C1-6 alkyl groups or by phenyl optionally substituted as defined hereinbefore for R, when phenyl, or Rg and R,o together represent a bond; or R2 and R3 together represent a bond; R4 and R5 together represent a bond; and R7 is hydrogen, C1-6 alkyl optionally substituted by hydroxy, amino disubstituted by c1-6 alkyl, or phenyl optionally substituted as defined hereinbefore for R, when phenyl; and R9 and R10 together represent a bond, having pharmacological activity, a process and intermediates for their preparation, compositions containing them and their use in the treatment of mammals.

  式(I)化合物及其药学上可接受的盐类： 其中 G 与其结合的两个碳原子是噻吩基； R，是任选被一个或多个 C1-6 烷基、C1-6 烷氧基、C1-6 烷硫基、羟基、C2-7 烷酰基、卤代、三氟甲基、硝基、任选被一个或两个 C1-6 烷基或 C2- 7 烷酰基、氰基、氨基甲酰基或羧基取代的苯基；或任选被 C1-6 烷基或卤代取代的吡啶基； R6 是氢、C1-6 烷基或前面定义的任选被 R1 取代的苯基（当为苯基时）； R8 是氢、前文所述 R 的任选取代基之一（当为苯基时）或任选被前文定义的 R 的任选取代基取代的苯基（当为苯基时）；以及 R2 是氢，或任选被羟基、被 C1-6 烷基取代的氨基或任选被前文定义的 R 的任选取代基取代的苯基取代的 C1-6 烷基（当为苯基时）； R3 和 R4 共同代表一个键； R5 和 R7 共同代表一个键；以及 R9 是氢，R10 是羟基、C1-6 烷氧基或氨基，可任选被一个或两个独立选择的 C1-6 烷基取代，或被前文定义的苯基任选取代的 R（当为苯基时），或 Rg 和 R,o 共同代表键； 或 R2 和 R3 共同代表一个键； R4 和 R5 共同代表一个键；以及 R7 是氢、任选被羟基取代的 C1-6 烷基、被 c1-6 烷基取代的氨基或任选被前文定义的 R 取代的苯基（当为苯基时）； 和 R9 和 R10 共同代表一种具有药理活性的键、制备它们的工艺和中间体、含有它们的组合物以及它们在治疗哺乳动物中的用途。
• RESIN COMPOSITION AND OPTICAL COMPENSATION FILM USING SAME
  申请人：Tosoh Corporation

  公开号：EP3208301A1

  公开（公告）日：2017-08-23

  To provide a resin composition suitable for an optical compensation film, an optical compensation film using the same, which is excellent in the retardation characteristics and wavelength dispersion characteristics, and a production method of an optical compensation film. A resin composition containing, as resin components, from 30 to 99 wt% of a cellulose-based resin represented by the following formula (1) and from 1 to 70 wt% of a cinnamic acid ester copolymer. (wherein each of R1, R2 and R3 independently represents hydrogen or a substituent having a carbon number of 1 to 12).

  提供一种适用于光学补偿膜的树脂组合物、一种使用了该树脂组合物的光学补偿膜，该光学补偿膜在延缓特性和波长色散特性方面都非常出色，还提供了一种光学补偿膜的生产方法。 一种树脂组合物，作为树脂成分，含有 30 至 99 wt%由下式（1）表示的纤维素基树脂和 1 至 70 wt%的肉桂酸酯共聚物。 (其中 R1、R2 和 R3 各自独立地代表氢或碳原子数为 1 至 12 的取代基）。
• Resin composition and optical compensation film using same
  申请人：TOSOH CORPORATION

  公开号：US10126478B2

  公开（公告）日：2018-11-13

  A resin composition suitable for an optical compensation film, an optical compensation film using the same, which is excellent in the retardation characteristics and wavelength dispersion characteristics, and a production method of an optical compensation film. A resin composition containing, as resin components, from 30 to 99 wt % of a cellulose-based resin represented by the following formula (1) and from 1 to 70 wt % of a cinnamic acid ester copolymer: where each of R1, R2 and R3 independently represents hydrogen or a substituent having a carbon number of 1 to 12.

  一种适用于光学补偿膜的树脂组合物、一种使用了该树脂组合物且延缓特性和波长色散特性优异的光学补偿膜，以及一种光学补偿膜的生产方法。一种树脂组合物，作为树脂成分，含有 30 至 99 wt % 下式（1）表示的纤维素基树脂和 1 至 70 wt % 肉桂酸酯共聚物： 其中 R1、R2 和 R3 各自独立地代表氢或碳原子数为 1 至 12 的取代基。
• Microwave-accelerated Wittig olefination of β-chloroacroleins
  作者：Rabin Bera、G. Dhananjaya、Shambu Nath Singh、Rajender Kumar、K. Mukkanti、Manojit Pal

  DOI：10.1016/j.tet.2008.12.036

  日期：2009.2

  The first microwave assisted Wittig reactions of beta-chloroacroleins with a stabilized ylide are described here. A combination of sodium ethoxide and toluene was found to be optimum and using this reaction condition a number of alkenyl-substituted benzopyran/benzo[b]oxepine/2-chromenone derivatives were prepared within few minutes. The microwave mediated process was found to be comparable with the conventional Wittig reaction in terms of product yields. All the products isolated were found to have E-geometry around the C=C bond. (C) 2008 Elsevier Ltd. All rights reserved.