2,3,5,6-tetrafluoroterephthalic acid difluoride | 950-70-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,5,6-tetrafluoroterephthalic acid difluoride
• 英文别名: 2,3,5,6-tetrafluoroterephthaloyl difluoride；tetrafluoroterephthalic difluoride；Tetrafluorterephthalsaeure-difluorid；2,3,5,6-Tetrafluorobenzene-1,4-dicarbonyl difluoride；2,3,5,6-tetrafluorobenzene-1,4-dicarbonyl fluoride
• CAS: 950-70-9
• 化学式: C₈F₆O₂
• 分子量: 242.077
• InChiKey: ROHSNXARKQFYRZ-UHFFFAOYSA-N

物化性质

• 熔点：
  94-95 °C
• 沸点：
  269.9±40.0 °C(Predicted)
• 密度：
  1.644±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2,3,5,6-tetrafluoroterephthalic acid difluoride 在 sodium tetrahydroborate 、 水 作用下， 以 环丁砜 、 甲苯 、 丙酮 为溶剂， 反应 1.33h， 以86%的产率得到2,3,5,6-四氟对苯二甲醇
  参考文献：
  名称：

  METHOD FOR PRODUCING 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL

  摘要：

  公开号：

  EP2123624B1
• 作为产物：
  描述：

  2,3,5,6-四氯对苯二甲酰氯 在 potassium fluoride 作用下， 以 环丁砜 为溶剂， 120.0~140.0 ℃ 、101.33 kPa 条件下， 生成 2,3,5,6-tetrafluoroterephthalic acid difluoride
  参考文献：
  名称：

  METHOD FOR PRODUCING 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL

  摘要：

  公开号：

  EP2123624B1

文献信息

• POTASSIUM FLUORIDE DISPERSION SOLUTION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME
  申请人：Hagiya Koji

  公开号：US20090099387A1

  公开（公告）日：2009-04-16

  A potassium fluoride dispersion essentially consisting of potassium fluoride and an aprotic organic solvent having a boiling point higher than that of methanol, which is obtainable by mixing a mixture containing potassium fluoride and 5 to 50 parts by weight of methanol per 1 part by weight of potassium fluoride with the aprotic organic solvent followed by concentrating the obtained mixture, and a process for producing a fluorine-containing organic compound comprising contacting an organic compound having at least one group capable of being substituted nucleophilically with a fluorine atom with the potassium fluoride dispersion.

  一种氟化钾分散体，基本上由氟化钾和沸点高于甲醇的无极性有机溶剂组成，可通过将含有氟化钾和每1份氟化钾重量配比5至50份甲醇的混合物与无极性有机溶剂混合后浓缩所得混合物而获得，以及一种制备含氟有机化合物的方法，包括将至少具有一个能够被氟原子亲核取代的基团的有机化合物与氟化钾分散体接触。
• ALKALI METAL FLUORIDE DISPERSION AND PROCESS FOR PRODUCING FLUORINE-CONTAINING ORGANIC COMPOUND USING THE SAME
  申请人：Hagiya Koji

  公开号：US20110112321A1

  公开（公告）日：2011-05-12

  An alkali metal fluoride dispersion essentially consisting of an alkali metal fluoride and an aprotic organic solvent obtainable by conducting the following Step (A), subsequently conducting the following Step (B) at least once, and then conducting the following Step(C); Step (A): a step of separating a liquid phase from an alkali metal fluoride dispersion comprising at least one alcohol solvent selected from the group consisting of methanol, ethanol and isopropanol and an alkali metal fluoride, and mixing the separated liquid phase with an aprotic organic solvent having a boiling point of 85° C. or higher at normal pressure to obtain a mixture containing the alkali metal fluoride; Step (B): a step of obtaining a mixture containing the alkali metal fluoride comprising the following Steps (b1) to (b3); Step (b1): a step of concentrating the mixture containing the alkali metal fluoride obtained in Step (A) or Step (b3) to obtain a concentrated fraction and a concentrated residue; Step (b2): a step of mixing a residue of the alkali metal fluoride dispersion obtained by separating the liquid phase in Step (A) or a residue of the mixture obtained by separating a liquid phase in Step (b3) with the concentrated fraction obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (b3): a step of separating a liquid phase from the mixture containing an alkali metal fluoride obtained in Step (b2) and mixing the separated liquid phase with the concentrated residue obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (C): a step of removing the alcohol solvent from the mixture containing the alkali metal fluoride, which is obtained in Step (B), to obtain the alkali metal fluoride dispersion essentially consisting of the alkali metal fluoride and the aprotic organic solvent.

  一种碱金属氟化物分散体，基本上由碱金属氟化物和无水有机溶剂组成，可通过进行以下步骤（A），随后至少进行以下步骤（B）一次，然后进行以下步骤（C）获得；步骤（A）：将包括甲醇、乙醇和异丙醇中至少一种醇溶剂和碱金属氟化物的碱金属氟化物分散体中的液相与沸点在常压下为85°C或更高的无水有机溶剂混合，以获得含有碱金属氟化物的混合物；步骤（B）：获取含有碱金属氟化物的混合物，包括以下步骤（b1）至（b3）；步骤（b1）：浓缩在步骤（A）或步骤（b3）中获得的含有碱金属氟化物的混合物，以获得浓缩分数和浓缩残渣；步骤（b2）：将通过在步骤（A）中分离液相获得的碱金属氟化物分散体残渣或通过在步骤（b3）中分离液相获得的混合物残渣与在步骤（b1）中获得的浓缩分数混合，以获得含有碱金属氟化物的混合物；步骤（b3）：从在步骤（b2）中获得的含有碱金属氟化物的混合物中分离液相，并将分离的液相与在步骤（b1）中获得的浓缩残渣混合，以获得含有碱金属氟化物的混合物；步骤（C）：从在步骤（B）中获得的含有碱金属氟化物的混合物中去除醇溶剂，以获得基本上由碱金属氟化物和无水有机溶剂组成的碱金属氟化物分散体。
• PROCESS FOR PRODUCING 4-METHYL-2,3,5,6-TETRAFLUOROBENZYL ALCOHOL
  申请人：Hagiya Koji

  公开号：US20100324344A1

  公开（公告）日：2010-12-23

  A process for producing 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol including the following steps: (A): a step for fluorinating 2,3,5,6-tetrachloroterephthaloyl dichloride, (B): a step for reducing the product obtained in step (A), (C): a step for chlorinating the product obtained in step (B), and Step (D): a step for hydrogenating the product obtained in step (C).

  一种生产4-甲基-2,3,5,6-四氟苯甲醇的过程，包括以下步骤：(A)：氟化2,3,5,6-四氯对苯二酰二氯，(B)：还原步骤（A）中得到的产物，(C)：氯化步骤（B）中得到的产物，以及步骤（D）：加氢步骤（C）中得到的产物。
• Fluorination process for the production of nuclear fluorinated phthaloyl- and terephthaloyl fluorides
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0140482A2

  公开（公告）日：1985-05-08

  Nuclear fluorinated phthaloyl and terephthaloyl fluorides, especially tetrafluoroterephthaloyl fluoride, are obtained by reacting a corresponding nuclear chlorinated acid halide with potassium fluoride in a polar aprotic solvent, preferably sulpholane, at a temperature of from 100 to 200°C, preferably 120 to 150°C. The products are useful chemical intermediates for the synthesis of pesticides.

  核氟化邻苯二甲酰基和对苯二甲酰基氟化物，特别是四氟对苯二甲酰基氟化物，是通过在极性非丙烷溶剂（最好是磺烷）中，在 100 至 200℃，最好是 120 至 150℃的温度下，使相应的核氯化酸卤化物与氟化钾反应而得到的。 这些产品是合成杀虫剂的有用化学中间体。
• ALKALI METAL FLUORIDE DISPERSION, AND PROCESS FOR PRODUCTION OF FLUORINATED ORGANIC COMPOUND USING THE SAME
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2192087A1

  公开（公告）日：2010-06-02

  An alkali metal fluoride dispersion essentially consisting of an alkali metal fluoride and an aprotic organic solvent obtainable by conducting the following Step (A), subsequently conducting the following Step (B) at least once, and then conducting the following Step(C); Step (A) : a step of separating a liquid phase from an alkali metal fluoride dispersion comprising at least one alcohol solvent selected from the group consisting of methanol, ethanol and isopropanol and an alkali metal fluoride, and mixing the separated liquid phase with an aprotic organic solvent having a boiling point of 85°C or higher at normal pressure to obtain a mixture containing the alkali metal fluoride; Step (B) : a step of obtaining a mixture containing the alkali metal fluoride comprising the following Steps (b1) to (b3); Step (b1) : a step of concentrating the mixture containing the alkali metal fluoride obtained in Step (A) or Step (b3) to obtain a concentrated fraction and a concentrated residue; Step (b2) : a step of mixing a residue of the alkali metal fluoride dispersion obtained by separating the liquid phase in Step (A) or a residue of the mixture obtained by separating a liquid phase in Step (b3) with the concentrated fraction obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (b3) : a step of separating a liquid phase from the mixture containing an alkali metal fluoride obtained in Step (b2) and mixing the separated liquid phase with the concentrated residue obtained in Step (b1) to obtain a mixture containing an alkali metal fluoride; and Step (C) : a step of removing the alcohol solvent fromthemixture containing the alkali metal fluoride, which is obtained in Step (B), to obtain the alkali metal fluoride dispersion essentially consisting of the alkali metal fluoride and the aprotic organic solvent.

  一种碱金属氟化物分散液，主要由碱金属氟化物和一种非烷基有机溶剂组成，可通过进行以下步骤(A)，随后进行至少一次以下步骤(B)，然后进行以下步骤(C)获得； 步骤(A)：从碱金属氟化物分散液中分离出液相的步骤，该分散液包含至少一种从甲醇、乙醇和异丙醇组成的组中选出的醇类溶剂和碱金属氟化物，并将分离出的液相与常压下沸点为 85℃或更高的无相有机溶剂混合，以获得含有碱金属氟化物的混合物； 步骤(B)：获得含碱金属氟化物混合物的步骤，包括以下步骤(b1)至(b3)； 步骤(b1)：浓缩在步骤(A)或步骤(b3)中获得的含碱金属氟化物的混合物的步骤，以 获得浓缩馏分和浓缩残留物； 步骤(b2)：将步骤(A)中分离液相得到的碱金属氟化物分散液的残留物或步骤(b3)中分离液相得到的混合物的残留物与步骤(b1)中得到的浓缩馏分混合，得到含有碱金属氟化物的混合物的步骤；以及 步骤(b3)：从步骤(b2)得到的含碱金属氟化物的混合物中分离出液相，并将分离出的液相与步骤(b1)得到的浓缩残渣混合，得到含碱金属氟化物的混合物；以及 步骤(C)：从步骤(B)得到的含有碱金属氟化物的混合物中除去醇溶剂，得到基本上由碱金属氟化物和无相有机溶剂组成的碱金属氟化物分散液。