兰吡立松盐酸盐 | 116287-13-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 兰吡立松盐酸盐
• 中文别名: (2R)-2-甲基-3-吡咯烷-1-基-1-[4-(三氟甲基)苯基]丙烷-1-酮盐酸
• 英文名称: Lanperisone hydrochloride
• 英文别名: (-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone monohydrochloride；NK433；(-)-(R)-2-methyl-3-(1-pyrrolidinyl)-4'-trifluoromethyl-propiophenone hydrochloride；(2R)-2-methyl-3-pyrrolidin-1-yl-1-[4-(trifluoromethyl)phenyl]propan-1-one;hydrochloride
• CAS: 116287-13-9
• 化学式: C₁₅H₁₈F₃NO*ClH
• 分子量: 321.77
• InChiKey: PHBZFPOOJUGYCR-RFVHGSKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.04
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  20.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-methyl-1-(4-trifluoromethylphenyl)-3-pyrrolidino-1-propanone 生成 兰吡立松盐酸盐
  参考文献：
  名称：

  Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

  摘要：

  Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series, 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.

  DOI：

  10.1016/0223-5234(96)88213-4

文献信息

• Lanperisone formulation
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0770386A1

  公开（公告）日：1997-05-02

  A lanperisone hydrochloride compression-molded formulation comprising the first granules containing lanperisone hydrochloride and the second granules containing substantially no lanperisone hydrochloride but at least one pharmaceutical additive(s) selected from the group consisting of sugars, crystalline celluloses and cellulose derivatives is an excellent formulation which has a high storage stability because the decomposition of lanperisone hydrochloride is suppressed.

  盐酸兰哌立松压缩模塑制剂由含有盐酸兰哌立松的第一种颗粒和基本上不含盐酸兰哌立松但含有至少一种从糖、结晶纤维素和纤维素衍生物组成的组中选出的药物添加剂的第二种颗粒组成，是一种出色的制剂，由于抑制了盐酸兰哌立松的分解，因此具有很高的贮存稳定性。
• Iontophoresis system
  申请人：HISAMITSU PHARMACEUTICAL CO. INC.

  公开号：EP1084729A2

  公开（公告）日：2001-03-21

  An iontophoresis system comprises a power supply apparatus having a chargeable battery, a positive output terminal, a negative output terminal and a positive charge terminal, and a preparation having input terminals connected to output terminals of the power supply apparatus. The negative output terminal of the power supply apparatus also serves as a negative charge terminal for charging the battery. During charging, the preparation is removed, and terminals of a charger are connected to terminals of the power supply apparatus, respectively. The power supply apparatus comprises a power supply monitoring portion which gives a warning when a battery voltage becomes a predetermined value or lower and a control portion for controlling a power supply state from the output terminal.

  离子渗透系统包括一个电源装置，该装置具有一个可充电电池、一个正输出端、一个负输出端和一个正充电端，以及一个制备装置，该制备装置的输入端与电源装置的输出端相连。电源装置的负输出端子同时也是为电池充电的负充电端子。在充电过程中，准备工作被移除，充电器的端子分别连接到电源装置的端子上。供电装置包括供电监控部分和控制部分，前者用于在电池电压达到或低于预定值时发出警告，后者用于控制输出端子的供电状态。
• WO2006/112565
  申请人：——

  公开号：——

  公开（公告）日：——
• Eur J Med Chem 1995, 30, 85-94
  作者：

  DOI：——

  日期：——
• JPH10287586A
  申请人：——

  公开号：JPH10287586A

  公开（公告）日：1998-10-27