2'-Aminochalcone Epoxide | 124856-99-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2'-Aminochalcone Epoxide
• 英文别名: (2-Aminophenyl)-(3-phenyloxiran-2-yl)methanone
• CAS: 124856-99-1
• 化学式: C₁₅H₁₃NO₂
• 分子量: 239.274
• InChiKey: XZOFYBSUOARQRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2'-Aminochalcone Epoxide 在 三氟甲磺酸 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 4-氯-3-苯基喹啉
  参考文献：
  名称：

  Praveen; Parthasarathy; Kumar, P. Senthil, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2015, vol. 54B, # 3, p. 373 - 382

  摘要：

  DOI：
• 作为产物：
  描述：

  2-aminochalcone 在 双氧水 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 生成 2'-Aminochalcone Epoxide
  参考文献：
  名称：

  Praveen; Parthasarathy; Kumar, P. Senthil, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2015, vol. 54B, # 3, p. 373 - 382

  摘要：

  DOI：

文献信息

• MILD AND CONVENIENT EPOXIDATION OF α,β-UNSATURATED KETONES BY AMBERLYST A-26 SUPPORTED HYDROPEROXIDE
  作者：M. M. Lakouraj、B. Movassagh、K. Bahrami

  DOI：10.1081/scc-100104010

  日期：2001.1.1

  The epoxidation of α,β-unsaturated ketones to the corresponding epoxy ketones, using amberlyst A-26 supported hydroperoxide, which is prepared in situ from (35%) hydrogen peroxide and amberlyst A-26(OH−), is described. Reactions were carried out at room temperature and the corresponding epoxides were isolated in excellent yields.

  描述了使用由 (35%) 过氧化氢和 amberlyst A-26(OH-) 原位制备的 amberlyst A-26 负载的氢过氧化物将 α,β-不饱和酮环氧化成相应的环氧酮。反应在室温下进行，相应的环氧化物以极好的收率分离。
• Gao, Feng; Johnson, Kurtis F.; Schlenoff, Joseph B., Journal of the Chemical Society. Perkin transactions II, 1996, # 2, p. 269 - 274
  作者：Gao, Feng、Johnson, Kurtis F.、Schlenoff, Joseph B.

  DOI：——

  日期：——
• The chemistry of 2'-amino analogs of 2'-hydroxychalcone and its derivatives
  作者：John A. Donnelly、David F. Farrell

  DOI：10.1021/jo00293a017

  日期：1990.3
• Synthesis and fluorescence properties of 2-aryl-3-hydroxyquinolones, a new class of dyes displaying dual fluorescence
  作者：Dmytro A. Yushchenko、Mykhailo D. Bilokin’、Oleksandr V. Pyvovarenko、Guy Duportail、Yves Mély、Vasyl G. Pivovarenko

  DOI：10.1016/j.tetlet.2005.11.160

  日期：2006.2

  A series of 2-aryl-3-hydroxyquinolones (3HQs) with different electron donating aryl substituents at the position 2 were synthesized. Their absorption and fluorescence properties were studied in solvents of medium and high polarity. Almost all the synthesized 3HQs display dual fluorescence in the tested solvents, in line with an excited state intramolecular proton transfer reaction. For N-methyl substituted compounds, the intensity ratio of the two emission bands was found to be exquisitely sensitive to solvent polarity, with a two orders of magnitude change from toluene to dimethylsulfoxide. Consequently, these compounds appear as prospective polarity fluorescent labels for proteins and nucleic acids. (c) 2005 Elsevier Ltd. All rights reserved.
• Tokes, Adrienne,; Janzco, Geza, Synthetic Communications, 1989, vol. 19, # 18, p. 3159 - 3168
  作者：Tokes, Adrienne,、Janzco, Geza

  DOI：——

  日期：——