8-hydroxy-N-(pyridin-2-ylmethyl)quinoline-7-carboxamide | 1313049-77-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-hydroxy-N-(pyridin-2-ylmethyl)quinoline-7-carboxamide
• CAS: 1313049-77-2
• 化学式: C₁₆H₁₃N₃O₂
• 分子量: 279.298
• InChiKey: OUQVDCHVZAXLKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  75.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨甲基吡啶 、 8-羟基喹啉-7-羧酸 在 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 8-hydroxy-N-(pyridin-2-ylmethyl)quinoline-7-carboxamide
  参考文献：
  名称：

  New secondary 8-hydroxyquinoline-7-carboxamide derivatives

  摘要：

  本发明提供了一种新的通式（I）的次级8-羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。其中许多化合物对白色念珠菌属（如白色念珠菌和光滑白色念珠菌）具有活性。

  公开号：

  EP2345641A1

文献信息

• [EN] SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS<br/>[FR] DÉRIVÉS DE 8-HYDROXYQUINOLINE-7-CARBOXAMIDE SECONDAIRES ET LEURS UTILISATIONS EN TANT QU'AGENTS ANTIFONGIQUES
  申请人：POLICHEM SA

  公开号：WO2011080265A1

  公开（公告）日：2011-07-07

  The present invention provides secondary 8-hydroxyquinoiine-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulahopsis Brevicaulis. These compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明提供了一般式（I）的二级8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体来说，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulahopsis Brevicaulis进行了测试。这些化合物对Candida Albicans和Candida Glabrata等念珠菌物种具有活性。
• Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
  申请人：POLICHEM S.A.

  公开号：EP2345642A1

  公开（公告）日：2011-07-20

  The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. These compounds are active against Candida species such as Candida Albicans and Candida Glabrata.

  本发明提供了一般式(I)的二次8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体而言，这些化合物已经针对红毛癣菌、拟毛癣菌、黑曲霉和短柄镰孢菌进行了测试。这些化合物对白色念珠菌属如白色念珠菌和光滑白色念珠菌具有活性。
• New secondary 8-hydroxyquinoline-7-carboxamide derivatives
  申请人：POLICHEM S.A.

  公开号：EP2345641A1

  公开（公告）日：2011-07-20

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis. Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata,

  本发明提供了一种新的通式（I）的次级8-羟基喹啉-7-甲酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。其中许多化合物对白色念珠菌属（如白色念珠菌和光滑白色念珠菌）具有活性。
• SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES
  申请人：Gagliardi Stefania

  公开号：US20120316167A1

  公开（公告）日：2012-12-13

  The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis . Many of these compounds are active against Candida species such as Candida Albicans and Candida Glabrata .

  本发明提供了新的通式（I）的二次8-羟基喹啉-7-羧酰胺衍生物及其药学上可接受的盐。这些化合物可用作抗真菌剂。具体地，这些化合物已经对Tricophyton Rubrum，Tricophyton Mentagrophytes，Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。其中许多化合物对Candida Albicans和Candida Glabrata等Candida物种具有活性。
• SECONDARY 8-HYDROXYQUINOLINE-7-CARBOXAMIDE DERIVATIVES FOR USE AS ANTIFUNGAL AGENTS
  申请人：Gagliardi Stefania

  公开号：US20120329797A1

  公开（公告）日：2012-12-27

  The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal agents. Specifically, these compounds were tested against Tricophyton Rubrum, Tricophyton Mentagrophytes, Aspergillus Niger and Scopulariopsis Brevicaulis . These compounds are active against Candida species such as Candida Albicans and Candida Glabrata .

  本发明提供了通式(I)及其药学上可接受的盐的二次8-羟基喹啉-7-羧酰胺衍生物。这些化合物可用作抗真菌剂。具体来说，这些化合物已经对Tricophyton Rubrum、Tricophyton Mentagrophytes、Aspergillus Niger和Scopulariopsis Brevicaulis进行了测试。这些化合物对Candida Albicans和Candida Glabrata等Candida物种具有活性。