4-chloro-7,8-dimethoxybenzo[g]quinoline-3-carbonitrile | 348617-25-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-chloro-7,8-dimethoxybenzo[g]quinoline-3-carbonitrile
• CAS: 348617-25-4
• 化学式: C₁₆H₁₁ClN₂O₂
• 分子量: 298.729
• InChiKey: OVSINPZJZRGUJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-chloro-7,8-dimethoxybenzo[g]quinoline-3-carbonitrile 在 吡啶盐酸盐 作用下， 以 乙二醇乙醚 为溶剂， 生成 4-(2,4-dichloroanilino)-7,8-dihydroxybenzo[g]quinoline-3-carbonitrile
  参考文献：
  名称：

  4-Anilino-3-cyanobenzo[g]quinolines as Kinase Inhibitors

  摘要：

  A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino- 3 -cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equally active against MAPK kinase (MEK), and more active against Src kinase. For Src kinase inhibition, the best activity is obtained when both the 7- and 8-positions are substituted with alkoxy groups. Several of these kinase inhibitors show potent growth inhibitory activity in tumor cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00776-4
• 作为产物：
  描述：

  6,7-dimethoxy-3-(methoxycarbonyl)-2-naphthoic acid 在 叠氮磷酸二苯酯 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 生成 4-chloro-7,8-dimethoxybenzo[g]quinoline-3-carbonitrile
  参考文献：
  名称：

  4-Anilino-3-cyanobenzo[g]quinolines as Kinase Inhibitors

  摘要：

  A series of 4-anilino-3-cyanobenzo[g]quinolines was prepared as potent kinase inhibitors. Compared with their bicyclic 4-anilino- 3 -cyanoquinoline analogues, the tricyclic 4-anilino-3-cyanobenzo[g]quinolines are less active against EGF-R kinase, equally active against MAPK kinase (MEK), and more active against Src kinase. For Src kinase inhibition, the best activity is obtained when both the 7- and 8-positions are substituted with alkoxy groups. Several of these kinase inhibitors show potent growth inhibitory activity in tumor cells. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00776-4

文献信息

• Tricyclic protein kinase inhibitors
  申请人：American Home Products Corporation

  公开号：US20010051620A1

  公开（公告）日：2001-12-13

  This invention provides compounds of formula 1, having the structure 1 which are useful as inhibitors of protein tyro sine kinase and are antiproliferative agents.

  这项发明提供了具有结构1的化合物，这些化合物可作为蛋白酪氨酸激酶的抑制剂，是抗增殖剂。
• [EN] TRICYCLIC PROTEIN KINASE INHIBITORS<br/>[FR] INHIBITEURS TRICYCLIQUES DE PROTEINE KINASE
  申请人：AMERICAN HOME PROD

  公开号：WO2001047892A1

  公开（公告）日：2001-07-05

  This invention provides compounds of formula (1) which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

  本发明提供了一种式子为(1)的化合物，它们可用作蛋白酪氨酸激酶的抑制剂并具有抗增殖作用。
• TRICYCLIC PROTEIN KINASE INHIBITORS
  申请人：Wyeth

  公开号：EP1242382A1

  公开（公告）日：2002-09-25
• US6638929B2
  申请人：——

  公开号：US6638929B2

  公开（公告）日：2003-10-28
• US7105531B2
  申请人：——

  公开号：US7105531B2

  公开（公告）日：2006-09-12