(3aR,4R,7aS)-2,2-dimethylhexahydrobenzo[d][1,3]dioxol-4-ol | 125711-73-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,4R,7aS)-2,2-dimethylhexahydrobenzo[d][1,3]dioxol-4-ol
• 英文别名: (3aR,4R,7aS)-2,2-dimethyl-3a,4,5,6,7,7a-hexahydro-1,3-benzodioxol-4-ol
• CAS: 125711-73-1
• 化学式: C₉H₁₆O₃
• 分子量: 172.224
• InChiKey: GWCAZIJIJCFJCT-GJMOJQLCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.05
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (3aR,4R,7aS)-2,2-dimethylhexahydrobenzo[d][1,3]dioxol-4-ol 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 (3aS,7aS)-2,2-dimethyltetrahydrobenzo[1,3]dioxol-4-on
  参考文献：
  名称：

  酶法合成1,2,3-环己三醇的手性异亚丙基衍生物

  摘要：

  2,3-O-异亚丙基-1-环己醇手性结构单元的制备是通过酶解其外消旋的乙酸酯或丁酸正丁酯而获得的高对映体纯度。

  DOI：

  10.1016/s0040-4039(00)99201-3
• 作为产物：
  描述：

  (+/-)-2,2-dimethyl-(3ar,7ac)-hexahydro-benzo[1,3]dioxol-4t-ol 在 4-二甲氨基吡啶 吡啶 、 sodium hydroxide 、 phosphate buffer 作用下， 反应 2.0h， 生成 (3aR,4R,7aS)-2,2-dimethylhexahydrobenzo[d][1,3]dioxol-4-ol
  参考文献：
  名称：

  酶法合成1,2,3-环己三醇的手性异亚丙基衍生物

  摘要：

  2,3-O-异亚丙基-1-环己醇手性结构单元的制备是通过酶解其外消旋的乙酸酯或丁酸正丁酯而获得的高对映体纯度。

  DOI：

  10.1016/s0040-4039(00)99201-3

文献信息

• Conformationally constrained analogues of 2-arachidonoylglycerol
  作者：Subramanian K. Vadivel、Sundararaman Vardarajan、Richard I. Duclos、JodiAnne T. Wood、Jianxin Guo、Alexandros Makriyannis

  DOI：10.1016/j.bmcl.2007.07.064

  日期：2007.11

  Novel monocyclic analogues of 2-arachidonoylglycerol (2-AG) were designed in order to explore the pharillacophoric conformations of this endocannabinoid ligand at the key cannabinergic proteins. All 2-arachidonoyl esters of 1,2,3-cyclohexanetriol [meso-7 (AM5504), ()+/- 8 (AM5503), and ineso-9 (AM5505)] were synthesized by regioselective acylation of 2,3-dihydroxycyclohexanone followed by selective reductions. The optically active isomers (+)-8 (AM4434) and (-)-8 (AM4435) were synthesized from (2S,3S)- and (2R,3R)-2,3-dihydroxycyclohexanone, respectively, via a chernoenzymatic route. These head group constrained and conformationally restricted analogues of 2-AG as well as the 1-keto precursors were evaluated as substrates for the endocannabinoid deactivating hydrolytic enzymes monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), and also were tested for their affinities for CBI and CB2 cannabinoid receptors. The observed biochemical differences between these ligands can help define the conformational requirements for 2-AG activity at each of the above endocannabinoid protein targets. (c) 2007 Elsevier Ltd. All rights reserved.
• DUMORTIER, L.;EYCKEN, J. VAN DER;VANDEWALLE, M., TETRAHEDRON LETT., 30,(1989) N4, C. 3201-3204
  作者：DUMORTIER, L.、EYCKEN, J. VAN DER、VANDEWALLE, M.

  DOI：——

  日期：——