2-amino-galacturonic acid | 94537-01-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-galacturonic acid
• 英文别名: D-Galactosaminuronsaeure, 2-Amino-2-desoxy-D-galacturonsaeure；(2S,3R,4R,5R)-5-amino-3,4,6-trihydroxyoxane-2-carboxylic acid
• CAS: 94537-01-6
• 化学式: C₆H₁₁NO₆
• 分子量: 193.156
• InChiKey: CRIPFXSBMSGPKB-BZINKQHNSA-N

物化性质

• 沸点：
  536.4±50.0 °C(Predicted)
• 密度：
  1.783±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  133
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-amino-galacturonic acid 、 乙酸酐 以 甲醇 为溶剂， 生成 2-acetamido-2-deoxy-D-galactopyranosyluronic acid
  参考文献：
  名称：

  Synthesis of 2-acetamido-2-deoxyhexuronic acids with the d-gluco, d-manno, and d-galacto configurations

  摘要：

  DOI：

  10.1016/s0008-6215(82)80021-9
• 作为产物：
  描述：

  methyl 3,4-di-O-acetyl-2,6-anhydro-5-deoxy-D-arabino-hex-5-enonate 在 palladium on activated charcoal 盐酸 、 sodium azide 、 ammonium cerium(IV) nitrate 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 反应 20.5h， 生成 2-amino-galacturonic acid
  参考文献：
  名称：

  Synthesis of 2-acetamido-2-deoxyhexuronic acids with the d-gluco, d-manno, and d-galacto configurations

  摘要：

  DOI：

  10.1016/s0008-6215(82)80021-9

文献信息

• ANTIBODY-DRUG CONJUGATE (ADC) AND METHOD FOR FORMING THE SAME
  申请人：Industrial Technology Research Institute

  公开号：US20170119902A1

  公开（公告）日：2017-05-04

  An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided. A-(L-D) p (I)

  提供了公式（I）的抗体药物结合物（ADC）或其药学上可接受的盐或溶剂。在公式（I）中，p是1到26的整数，A是抗体，而-（L-D）是连接-药物单元。L是具有糖肽的连接单元，D是药物单元。通过抗体的半胱氨酸残基将抗体与连接单元结合。还提供了一种形成抗体药物结合物（ADC）的方法。A-（L-D）p（I）
• Compounds, linker-drugs and ligand-drug conjugates
  申请人：Industrial Technology Research Institute

  公开号：US10233212B2

  公开（公告）日：2019-03-19

  A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently, hydrogen, amino, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxylic acid, C1-C6 alkoxycarbonyl, C1-C6 amino, C1-C6 aminocarbonyl, C1-C6 alkyl, branched C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclic, aryl or heteroaryl, provided at least one of R1 and R3 is an amino group. A linker-drug and a ligand-drug conjugate including the compound are also provided.

  本发明提供了式 (I) 的化合物或其药学上可接受的盐或溶液。在式 (I) 中，R1、R2 和 R3 各自独立地为氢、氨基、硝基、卤素、羟基、C1-C6 烷氧基、羧酸、C1-C6 烷氧羰基、C1-C6 氨基、C1-C6 氨基羰基、C1-C6 烷基、支链 C1-C6 烷基、C1-C6 环烷基、C1-C6 杂环基、芳基或杂芳基，条件是 R1 和 R3 中至少有一个是氨基。还提供了包括该化合物的连接体-药物和配体-药物共轭物。
• COMPOUNDS, LINKER-DRUGS AND LIGAND-DRUG CONJUGATES
  申请人：Industrial Technology Research Institute

  公开号：US20180016300A1

  公开（公告）日：2018-01-18

  A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), R1, R2 and R3 are each, independently, hydrogen, amino, nitro, halogen, hydroxyl, C1-C6 alkoxy, carboxylic acid, C1-C6 alkoxycarbonyl, C1-C6 amino, C1-C6 aminocarbonyl, C1-C6 alkyl, branched C1-C6 alkyl, C1-C6 cycloalkyl, C1-C6 heterocyclic, aryl or heteroaryl, provided at least one of R1 and R3 is an amino group. A linker-drug and a ligand-drug conjugate including the compound are also provided.
• Synthesis of 2-acetamido-2-deoxyhexuronic acids with the d-gluco, d-manno, and d-galacto configurations
  作者：Efthymios Darakas、Hans Hultberg、Karin Leontein、Jörgen Lönngren

  DOI：10.1016/s0008-6215(82)80021-9

  日期：1982.5