6-(4-chlorophenyl)-2,8,8-trimethyl-7,9-dihydro-5aH-chromeno[2,3-b]quinoline-10,12-dione | 1609119-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(4-chlorophenyl)-2,8,8-trimethyl-7,9-dihydro-5aH-chromeno[2,3-b]quinoline-10,12-dione
• CAS: 1609119-77-8
• 化学式: C₂₅H₂₂ClNO₃
• 分子量: 419.908
• InChiKey: YBRSPWJIANUNOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  30
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-甲基-4-氧-4H-1-苯并吡喃-3-甲醛 、 对氯苯胺 、 5,5-二甲基-1,3-环己二酮 在 四丁基溴化铵 作用下， 以 水 为溶剂， 反应 0.25h， 生成 6-(4-chlorophenyl)-2,8,8-trimethyl-7,9-dihydro-5aH-chromeno[2,3-b]quinoline-10,12-dione 、
  参考文献：
  名称：

  A one-pot three-component reaction in aqueous micellar medium: an easy route to chromeno[2,3-b]quinolinedione

  摘要：

  An efficient and green synthesis of hitherto unreported 5-aryl-3,3-dimethyl-2,3-dihydro-5aH-chromeno[2,3-b]quinoline-1,11(4H,5H)dione has been accomplished by a three-component reaction involving chromone-3-carbaldehyde, an aromatic amine, and 5,5-dimethyl-1,3-cyclohexanedione (dimedone) in 1.8 M aqueous TBAB solution. It is noteworthy that the TBAB/H2O system can be recovered and reused for seven cycles directly. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.03.072

文献信息

• A one-pot three-component reaction in aqueous micellar medium: an easy route to chromeno[2,3-b]quinolinedione
  作者：Jaydip Ghosh、Pritam Biswas、Tapas Sarkar、Michael G.B. Drew、Chandrakanta Bandyopadhyay

  DOI：10.1016/j.tetlet.2014.03.072

  日期：2014.4

  An efficient and green synthesis of hitherto unreported 5-aryl-3,3-dimethyl-2,3-dihydro-5aH-chromeno[2,3-b]quinoline-1,11(4H,5H)dione has been accomplished by a three-component reaction involving chromone-3-carbaldehyde, an aromatic amine, and 5,5-dimethyl-1,3-cyclohexanedione (dimedone) in 1.8 M aqueous TBAB solution. It is noteworthy that the TBAB/H2O system can be recovered and reused for seven cycles directly. (C) 2014 Elsevier Ltd. All rights reserved.