6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetic acid | 274264-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetic acid
• 英文别名: 2-[2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridin-3-yl]acetic acid
• CAS: 274264-03-8
• 化学式: C₁₆H₁₃BrN₂O₂
• 分子量: 345.195
• InChiKey: WZDTZJKCVJOMAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二甲胺 、 6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetic acid 在 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 为溶剂， 以72%的产率得到6-methyl-2-(4'-bromophenyl)-3-(N,N-dimethyl)imidazo[1,2-a]pyridine-3-acetamide
  参考文献：
  名称：

  Synthesis of [123I]N?,N?-dimethyl-6-methyl-(-4?-iodophenyl)imidazo[1,2-a]pyridine-3-acetamide for the study of peripheral benzodiazepine receptors using SPECT

  摘要：

  The [I-123] labelled imidazo[1,2-a]pyridine [I-123]iodozolpidem 4 was found to exhibit preferential activity towards Peripheral rather than Central Benzodiazepine receptors in vivo and was synthesised for the potential study of the Peripheral Benzodiazepine Receptors (PBR) using SPECT. [I-123]Iodozolpidem was prepared from the corresponding tributyl tin precursor by iododestannylation with Na[I-123] in the presence of peracetic acid or chloramine-T. Purification by semipreparative C-18 RP HPLC gave the product in radiochemical yields of 60-85%. The product was obtained in > 97% chemical and radiochemical puritiy with a specific activity > 80 GBq/mu mol.

  DOI：

  10.1002/(sici)1099-1344(20000330)43:4<385::aid-jlcr325>3.0.co;2-k
• 作为产物：
  描述：

  6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetonitrile 在 盐酸 作用下， 以 溶剂黄146 为溶剂， 反应 16.0h， 以85%的产率得到6-methyl-2-(4'-bromophenyl)imidazo[1,2-a]pyridine-3-acetic acid
  参考文献：
  名称：

  Synthesis of [123I]N?,N?-dimethyl-6-methyl-(-4?-iodophenyl)imidazo[1,2-a]pyridine-3-acetamide for the study of peripheral benzodiazepine receptors using SPECT

  摘要：

  The [I-123] labelled imidazo[1,2-a]pyridine [I-123]iodozolpidem 4 was found to exhibit preferential activity towards Peripheral rather than Central Benzodiazepine receptors in vivo and was synthesised for the potential study of the Peripheral Benzodiazepine Receptors (PBR) using SPECT. [I-123]Iodozolpidem was prepared from the corresponding tributyl tin precursor by iododestannylation with Na[I-123] in the presence of peracetic acid or chloramine-T. Purification by semipreparative C-18 RP HPLC gave the product in radiochemical yields of 60-85%. The product was obtained in > 97% chemical and radiochemical puritiy with a specific activity > 80 GBq/mu mol.

  DOI：

  10.1002/(sici)1099-1344(20000330)43:4<385::aid-jlcr325>3.0.co;2-k

文献信息

• Synthesis of [123I]N?,N?-dimethyl-6-methyl-(-4?-iodophenyl)imidazo[1,2-a]pyridine-3-acetamide for the study of peripheral benzodiazepine receptors using SPECT
  作者：Andrew Katsifis、Filomena Mattner、Zhianko Zhang、Branko Dikic、Vahan Papazian

  DOI：10.1002/(sici)1099-1344(20000330)43:4<385::aid-jlcr325>3.0.co;2-k

  日期：2000.3.30

  The [I-123] labelled imidazo[1,2-a]pyridine [I-123]iodozolpidem 4 was found to exhibit preferential activity towards Peripheral rather than Central Benzodiazepine receptors in vivo and was synthesised for the potential study of the Peripheral Benzodiazepine Receptors (PBR) using SPECT. [I-123]Iodozolpidem was prepared from the corresponding tributyl tin precursor by iododestannylation with Na[I-123] in the presence of peracetic acid or chloramine-T. Purification by semipreparative C-18 RP HPLC gave the product in radiochemical yields of 60-85%. The product was obtained in > 97% chemical and radiochemical puritiy with a specific activity > 80 GBq/mu mol.