2,7-dihydroxy-9-acridinone | 107566-95-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,7-dihydroxy-9-acridinone
• 英文别名: 2,7-Dihydroxyacridan-9-one；2,7-dihydroxy-10H-acridin-9-one；2,7-Dihydroxy-10H-acridin-9-on；2,7-dihydroxy-10H-acridin-9-one
• CAS: 107566-95-0
• 化学式: C₁₃H₉NO₃
• 分子量: 227.219
• InChiKey: HZABBKIWIUIFKD-UHFFFAOYSA-N

物化性质

• 沸点：
  465.2±45.0 °C(Predicted)
• 密度：
  1.461±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,7-dihydroxy-9-acridinone 在 劳森试剂 作用下， 以 四氢呋喃 为溶剂， 生成 2,7-dihydroxy-10H-acridine-9-thione
  参考文献：
  名称：

  Structure–activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors

  摘要：

  Haspin is a serine/threonine kinase required for completion of normal mitosis that is highly expressed during cell proliferation, including in a number of neoplasms. Consequently, it has emerged as a potential therapeutic target in oncology. A high throughput screen of approximately 140,000 compounds identified an acridine analog as a potent haspin kinase inhibitor. Profiling against a panel of 270 kinases revealed that the compound also exhibited potent inhibitory activity for DYRK2, another serine/threonine kinase. An optimization study of the acridine series revealed that the structure-activity relationship (SAR) of the acridine series for haspin and DYRK2 inhibition had many similarities. However, several structural differences were noted that allowed generation of a potent haspin kinase inhibitor (33, IC(50) <60 nM) with 180fold selectivity over DYRK2. In addition, a moderately potent DYRK2 inhibitor (41, IC(50) <400 nM) with a 5.4-fold selectivity over haspin was also identified. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.150
• 作为产物：
  描述：

  5-甲氧基-2-(4-甲氧基苯基氨基)苯甲酸 在 盐酸 、 水 、 三氯氧磷 作用下， 生成 2,7-dihydroxy-9-acridinone
  参考文献：
  名称：

  Kshatriya et al., Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1946, vol. 15/A, p. 42

  摘要：

  DOI：

文献信息

• FLUORESCENT PROBE FOR CYCLOOXYGENASE-2
  申请人：The Board of Trustees of the University of Illinois

  公开号：US20210330822A1

  公开（公告）日：2021-10-28

  Cyclooxygenase-2 (COX-2) over-expression is prominent in inflammatory diseases, neurodegenerative disorders, and cancer. Directly monitoring COX-2 activity within its native environment poses an exciting approach to account for and illuminate the effect of the local environments on protein activity. Herein, we report the development of CoxFluor, the first activity-based sensing approach for monitoring COX-2 within live cells with confocal microscopy and flow cytometry. CoxFluor strategically links a natural substrate with a dye precursor to engage both the cyclooxygenase and peroxidase activities of COX-2. This catalyzes the release of resorufin and the natural product, as supported by molecular dynamics and ensemble docking. CoxFluor enabled the detection of oxygen-dependent changes in COX-2 activity that are independent of protein expression within live macrophage cells.

  环氧合酶-2（COX-2）在炎症性疾病、神经退行性疾病和癌症中的过度表达是显著的。直接监测COX-2在其天然环境中的活性提供了一种令人兴奋的方法，可以解释和阐明局部环境对蛋白质活性的影响。在这里，我们报告了CoxFluor的开发，这是第一种用于监测活细胞内COX-2活性的基于活性的传感方法，使用共聚焦显微镜和流式细胞术。CoxFluor巧妙地将天然底物与染料前体相连，以同时参与COX-2的环氧合酶和过氧化物酶活性。这催化了鲁苏芬和天然产物的释放，得到了分子动力学和集合对接的支持。CoxFluor使得能够检测到在活细胞内与氧气有关的COX-2活性变化，这种变化与蛋白质表达无关，发生在活性巨噬细胞中。
• Crown Ethers Derived from 2,7-Dihydroxyacridine and 2,7-Dihydroxyacridan-9-one
  作者：Alain Vichet、Anne-Marie Patellis、Jean-Pierre Galy、Anne-Marie Galy、Jacques Barbe、Jose Elguero

  DOI：10.1021/jo00097a016

  日期：1994.9

  We report the synthesis of nine acridine crown ethers 11a, 11b, 12a, 12b, 13a, 13b, 14b, 15b, and 16b having one or two acridine rings linked by poly(ethylene glycol) chains. Their H-1 and C-13 NMR spectra have been analyzed and the chemical shifts related to conformational aspects of the chain and to the tautomerism of the acridan-9-one ring. The transport rates have been determined for compounds 11b and 12b against a large variety of ions. While compound 11b is devoid of complexing properties, compound 12b transports Fe2+, Cu+, and Ag+ but not alkali-metal cations.
• Structure–activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors
  作者：Gregory D. Cuny、Maxime Robin、Natalia P. Ulyanova、Debasis Patnaik、Valerie Pique、Gilles Casano、Ji-Feng Liu、Xiangjie Lin、Jun Xian、Marcie A. Glicksman、Ross L. Stein、Jonathan M.G. Higgins

  DOI：10.1016/j.bmcl.2010.04.150

  日期：2010.6

  Haspin is a serine/threonine kinase required for completion of normal mitosis that is highly expressed during cell proliferation, including in a number of neoplasms. Consequently, it has emerged as a potential therapeutic target in oncology. A high throughput screen of approximately 140,000 compounds identified an acridine analog as a potent haspin kinase inhibitor. Profiling against a panel of 270 kinases revealed that the compound also exhibited potent inhibitory activity for DYRK2, another serine/threonine kinase. An optimization study of the acridine series revealed that the structure-activity relationship (SAR) of the acridine series for haspin and DYRK2 inhibition had many similarities. However, several structural differences were noted that allowed generation of a potent haspin kinase inhibitor (33, IC(50) <60 nM) with 180fold selectivity over DYRK2. In addition, a moderately potent DYRK2 inhibitor (41, IC(50) <400 nM) with a 5.4-fold selectivity over haspin was also identified. (C) 2010 Elsevier Ltd. All rights reserved.
• Kshatriya et al., Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1946, vol. 15/A, p. 42
  作者：Kshatriya et al.

  DOI：——

  日期：——