2-chloro-8-methyl-3-(2-nitrovinyl)quinoline | 1031929-18-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-chloro-8-methyl-3-(2-nitrovinyl)quinoline
• 英文别名: 2-Chloro-8-methyl-3-(2-nitroethenyl)quinoline
• CAS: 1031929-18-6
• 化学式: C₁₂H₉ClN₂O₂
• 分子量: 248.669
• InChiKey: HQGAWPNIBDCSMC-UHFFFAOYSA-N

物化性质

• 沸点：
  410.8±40.0 °C(Predicted)
• 密度：
  1.364±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  58.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-8-甲基喹啉-3-甲醛 、 硝基甲烷 在 mesoporous nickel hydroxyapatite nanocomposite 作用下， 反应 0.02h， 以75.6%的产率得到2-chloro-8-methyl-3-(2-nitrovinyl)quinoline
  参考文献：
  名称：

  Mesoporous nickel hydroxyapatite nanocomposite for microwave-assisted Henry reaction

  摘要：

  The utility of nickel hydroxyapatite nanocomposite (Ni-HAp) as a green catalyst for solvent free, microwave-assisted Henry reaction using nitromethane and a series of aromatic aldehydes as substrates is presented. The selected catalyst performed well to afford the respective nitrostyrenes which were quantified by gas chromatography equipped with a mass spectral detector (GC-MS). A few of the products were identified from the respective nuclear magnetic resonance (NMR) spectral data. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.086

文献信息

• Mesoporous nickel hydroxyapatite nanocomposite for microwave-assisted Henry reaction
  作者：N. Neelakandeswari、G. Sangami、P. Emayavaramban、R. Karvembu、N. Dharmaraj、Hak Yong Kim

  DOI：10.1016/j.tetlet.2012.03.086

  日期：2012.6

  The utility of nickel hydroxyapatite nanocomposite (Ni-HAp) as a green catalyst for solvent free, microwave-assisted Henry reaction using nitromethane and a series of aromatic aldehydes as substrates is presented. The selected catalyst performed well to afford the respective nitrostyrenes which were quantified by gas chromatography equipped with a mass spectral detector (GC-MS). A few of the products were identified from the respective nuclear magnetic resonance (NMR) spectral data. (C) 2012 Elsevier Ltd. All rights reserved.