5-[(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)methylidene]-1,3-diazinane-2,4,6-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)methylidene]-1,3-diazinane-2,4,6-trione
• 化学式: C₁₆H₁₀N₄O₃S
• 分子量: 338.346
• InChiKey: SXVQAPSGETWERS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  巴比妥酸 、 6-苯基-咪唑并[2,1-b]噻唑-5-甲醛 在 sodium acetate 、 溶剂黄146 作用下， 生成 5-[(6-Phenylimidazo[2,1-b][1,3]thiazol-5-yl)methylidene]-1,3-diazinane-2,4,6-trione
  参考文献：
  名称：

  Synthesis and cardiotonic activity of imidazo[2,l-b]thiazoles bearing a lactam ring

  摘要：

  This paper describes the synthesis of 6-substituted imidazo[2,1-b] thiazoles with a lactam ring connected, by means of a methine group, to the 5-position. The pharmacological results show that interesting cardiotonic activity is obtained when the lactam ring is pseudothiohydantoin (8) or barbituric acid (9). Even the substituent at position 6 plays an important role in the pharmacological behavior of these derivatives. The following activity rank order was observed: phenyl > methyl > chlorine.

  DOI：

  10.1016/0223-5234(96)89164-1

文献信息

• Synthesis and cardiotonic activity of imidazo[2,l-b]thiazoles bearing a lactam ring
  作者：A Andreani、M Rambaldi、A Leoni、A Locatelli、R Bossa、M Chiericozzi、I Galatulas、G Salvatore

  DOI：10.1016/0223-5234(96)89164-1

  日期：1996.1

  This paper describes the synthesis of 6-substituted imidazo[2,1-b] thiazoles with a lactam ring connected, by means of a methine group, to the 5-position. The pharmacological results show that interesting cardiotonic activity is obtained when the lactam ring is pseudothiohydantoin (8) or barbituric acid (9). Even the substituent at position 6 plays an important role in the pharmacological behavior of these derivatives. The following activity rank order was observed: phenyl > methyl > chlorine.