pent-4-en-1-yl 6(IV)-O-((2-naphthyl)methyl)-2(IV),3(IV),2(III),3(III),6(III),2(II),3(II),6(II),2,3,6-undeca-O-acetyl-1-thio-β-maltotetraoside | 1355163-72-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: pent-4-en-1-yl 6(IV)-O-((2-naphthyl)methyl)-2(IV),3(IV),2(III),3(III),6(III),2(II),3(II),6(II),2,3,6-undeca-O-acetyl-1-thio-β-maltotetraoside
• CAS: 1355163-72-2
• 化学式: C₆₂H₈₀O₃₁S
• 分子量: 1353.36
• InChiKey: ASHMPPNRZZYZGP-IAZAUVGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.61
• 重原子数：
  94.0
• 可旋转键数：
  29.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  383.37
• 氢给体数：
  1.0
• 氢受体数：
  32.0

反应信息

• 作为反应物：
  描述：

  pent-4-en-1-yl 6(IV)-O-((2-naphthyl)methyl)-2(IV),3(IV),2(III),3(III),6(III),2(II),3(II),6(II),2,3,6-undeca-O-acetyl-1-thio-β-maltotetraoside 在 甲醇 、 sodium methylate 作用下， 以93%的产率得到pent-4-en-1-yl 6(IV)-O-((2-naphthyl)methyl)-1-thio-β-maltotetraoside
  参考文献：
  名称：

  Synthetic studies of bi-fluorescence-labeled maltooligosaccharides as substrates for α-amylase on the basis of fluorescence resonance energy transfer (FRET)

  摘要：

  A series of bi-fluorescence-labeled maltooligosaccharides that lead to fluorescence resonance energy transfer (FRET) was systematically synthesized. Effective FRETs were observed with all of the synthesized probes. Digestion of probes having tetra-, quintet-, hexa- or hepta-saccharidic chain lengths with human saliva alpha-amylase resulted in disappearance of FRET when an excitation wavelength of at 290 nm was used followed by detection at ca. 520 nm due to emission from the dansyl moiety. However, continuous FRET was observed when probes having di- or trisaccharidic chain lengths were used as substrates. In addition to the substrate characteristics based on saccharidic chain length, the reaction rates of digestion for the substrates by amylase were different and also depended on their saccharidic chain length. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.065
• 作为产物：
  描述：

  pent-4-en-1-yl 4(IV),6(IV)-di-O-((2-naphthyl)methylidene)-2(IV),3(IV),2(III),3(III),6(III),2(II),3(II),6(II),2,3,6-undeca-O-acetyl-1-thio-β-maltotetraoside 在 硼烷-三甲胺络合物 、 aluminum (III) chloride 、 盐酸 作用下， 以 四氢呋喃 、 氯仿 、 水 为溶剂， 反应 3.0h， 以59.1%的产率得到pent-4-en-1-yl 6(IV)-O-((2-naphthyl)methyl)-2(IV),3(IV),2(III),3(III),6(III),2(II),3(II),6(II),2,3,6-undeca-O-acetyl-1-thio-β-maltotetraoside
  参考文献：
  名称：

  Synthetic studies of bi-fluorescence-labeled maltooligosaccharides as substrates for α-amylase on the basis of fluorescence resonance energy transfer (FRET)

  摘要：

  A series of bi-fluorescence-labeled maltooligosaccharides that lead to fluorescence resonance energy transfer (FRET) was systematically synthesized. Effective FRETs were observed with all of the synthesized probes. Digestion of probes having tetra-, quintet-, hexa- or hepta-saccharidic chain lengths with human saliva alpha-amylase resulted in disappearance of FRET when an excitation wavelength of at 290 nm was used followed by detection at ca. 520 nm due to emission from the dansyl moiety. However, continuous FRET was observed when probes having di- or trisaccharidic chain lengths were used as substrates. In addition to the substrate characteristics based on saccharidic chain length, the reaction rates of digestion for the substrates by amylase were different and also depended on their saccharidic chain length. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.065