3-(1,3-dioxolan-2-yl)quinoline-2-thiol | 1226639-50-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(1,3-dioxolan-2-yl)quinoline-2-thiol
• 英文别名: 3-(1,3-dioxolan-2-yl)-1H-quinoline-2-thione
• CAS: 1226639-50-4
• 化学式: C₁₂H₁₁NO₂S
• 分子量: 233.291
• InChiKey: RIIKRWAHWKOMPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乙二醇 、 3-formyl-2-mercaptoquinoline 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以71%的产率得到3-(1,3-dioxolan-2-yl)quinoline-2-thiol
  参考文献：
  名称：

  An Efficient, Microwave-Assisted, One-Pot Synthesis of Dioxolano Quinoline/benzo[h]quinolines as Potent Antibacterial Agents

  摘要：

  Quinolines/benzo[h]quinolines are associated with a broad spectrum of biological activities. In view of this, 3-(1,3-dioxolan-2-yl)quinoline/benzo[h]quinoline-2-thiol/selenols were prepared under microwave irradiation through one-pot reactions, and these quinolines/ benzo[h]quinolines were evaluated for potential antibacterial activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426500902797095

文献信息

• An Efficient, Microwave-Assisted, One-Pot Synthesis of Dioxolano Quinoline/benzo[<i>h</i>]quinolines as Potent Antibacterial Agents
  作者：H. R. Prakash Naik、H. S. Bhojya Naik、T. R. Ravikumar Naik、D. S. Lamani、T. Aravinda

  DOI：10.1080/10426500902797095

  日期：2010.1.29

  Quinolines/benzo[h]quinolines are associated with a broad spectrum of biological activities. In view of this, 3-(1,3-dioxolan-2-yl)quinoline/benzo[h]quinoline-2-thiol/selenols were prepared under microwave irradiation through one-pot reactions, and these quinolines/ benzo[h]quinolines were evaluated for potential antibacterial activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.