4,4-diisopropyl-2,5-dimethyl-hexan-3-one | 54580-25-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,4-diisopropyl-2,5-dimethyl-hexan-3-one
• 英文别名: 4,4-Diisopropyl-2,5-dimethyl-hexan-3-on；2,5-Dimethyl-4,4-di(propan-2-yl)hexan-3-one
• CAS: 54580-25-5
• 化学式: C₁₄H₂₈O
• 分子量: 212.376
• InChiKey: VJRTUYLTYRZQET-UHFFFAOYSA-N

物化性质

• 沸点：
  98 °C(Press: 9 Torr)
• 密度：
  0.8683 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  4.17
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  acide diisopropyl-2,2 methyl-3 butyrique 在 氯化亚砜 作用下， 以 四氢呋喃 为溶剂， 反应 120.0h， 生成 4,4-diisopropyl-2,5-dimethyl-hexan-3-one
  参考文献：
  名称：

  Dubois, Jacques-Emile; Lion, Claude; Arouisse, Abdelmajid, Bulletin des Societes Chimiques Belges, 1984, vol. 93, # 12, p. 1083 - 1088

  摘要：

  DOI：

文献信息

• Uranyl complexes with 1,2-diols and tetrahydrofurfuryl alcohols
  作者：Claude Villiers、Pierre Thuéry、Michel Ephritikhine

  DOI：10.1016/j.poly.2012.07.100

  日期：2012.10

  2,3-Dimethyl-2,3-butanediol (pinacol, L-1) reacted with uranyl nitrate and acetate hydrates to give [UO2 (NO3)(2)(L-1)]center dot L-1 (1.L-1) and [UO2(OAc)(2)(L-1)] (2), while 2,5-dimethyl-3,4-di-iso-propyl-3,4-hexanediol (L-2) was found to undergo a pinacol rearrangement into the ketone R3CCOR (R = iPr) in the presence of uranyl complexes. Treatment of [UO2(NO3)(0)(H2O)(2)]center dot 4H(2)O with tetrahydrofurfuryl alcohol (L-3) and alpha,alpha-diter-tiobutyltetrahydrofurfuryl alcohol (L-4) led to the formation of [UO2(NO3)(2)(L-3)]center dot H2O (3 center dot H2O) and [UO2 (NO3)(2)(L-4)] (4). The crystal structures show that the metal coordination is similar in the 1,2-diol and ether-alcohol complexes but, in contrast to 1.L-1, 2 and 3 center dot H2O which form one- or two-dimensional hydrogen bonded assemblages, the structure of 4 is composed of discrete molecules, due to the lack of intermolecular hydrogen bonds. The crystal structure of uncomplexed L-2 is also described. (C) 2012 Elsevier Ltd. All rights reserved.
• Synthesis of tetraisopropylethane and tetracyclopropylethane, and generation of the pentacyclopropylethyl carbocation
  作者：Manfred Bruch、Young Moo Jun、Alan E. Luedtke、Manfred Schneider、Jack W. Timberlake

  DOI：10.1021/jo00365a022

  日期：1986.7
• Podocyte Injury Promotes Progressive Nephropathy in Zucker Diabetic Fatty Rats
  作者：Sachi Hoshi、Yujing Shu、Fusayo Yoshida、Tomoko Inagaki、Jiro Sonoda、Teruo Watanabe、Ken-ichi Nomoto、Michio Nagata

  DOI：10.1038/labinvest.3780392

  日期：2002.1

  The zucker diabetic fatty (ZDF-fa/fa) rat is one of the attractive models for type II diabetes based on impaired glucose tolerance caused by the inherited insulin-resistance gene fa. Characterization of nephropathy in this model may provide useful insights into the mechanism of the progression of diabetic nephropathy. The present study analyzed the pathophysiology of diabetes and nephropathy, including the process of glomerulosclerosis in this model by biochemical and morphometric analyses. In addition, we conducted studies in podocytes in culture to examine the direct effects of high glucose on podocytes. ZDF-fa/fa rats showed overt diabetes despite hyperinsulinemia as early as 3 months of age. Blood glucose levels increased further with a considerable decrease of insulin levels at 5 months. Glomerular filtration rate (GFR) was significantly elevated until 3 months, but fell to the level seen in lean rats by 7 months. Proteinuria started to rise during the period of increased GFR, and increased further after GFR had fallen to within the normal range. Renal fibronectin, collagen iv, and vascular endothelial growth factor mRNA levels were increased at 7 months. Glomerulosclerosis commenced as early as 5 months of age, and was associated with glomerular hypertrophy and mild mesangial expansion with evidence of accentuated podocyte injury, as revealed by increased expression of desmin. Electron microscopy suggested that degeneration of podocytes and the development of tuft adhesions were responsible for the glomerular sclerosis in this model. In addition, glomeruli from the diabetic rats showed up-regulation of the cyclin kinase inhibitors, p21 and p27. Further studies suggested that the increase in p27 expression was predominantly caused by podocytes, because predominant immunolocalization of p27 in podocytes in diabetic rats and high glucose medium induced cell hypertrophy accompanied by p27 up-regulation in differentiated podocyte cell lines. In conclusion, progressive diabetic nephropathy in ZDF-fa/fa rats is associated with evidence of podocyte injury. High concentrations of ambient glucose induced podocyte hypertrophy and stress in vitro, suggesting that the podocyte is a likely target of the diabetic milieu.
• Dubois, Jacques-Emile; Saumtally, Imran; Lion, Claude, Bulletin de la Societe Chimique de France, 1982, vol. <2> 2, # 9-10, p. 318 - 320
  作者：Dubois, Jacques-Emile、Saumtally, Imran、Lion, Claude

  DOI：——

  日期：——
• DUBOIS, J. -E.;SAUMTALLY, I.;LION, C., BULL. SOC. CHIM. FRANCE, 1982, N 9-10, 318-320
  作者：DUBOIS, J. -E.、SAUMTALLY, I.、LION, C.

  DOI：——

  日期：——