4-(2-丙烯基)-1,3-环戊二酮 | 76779-05-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-(2-丙烯基)-1,3-环戊二酮
• 英文名称: 4-(2-propenyl)-1,3-cyclopentanedione
• 英文别名: 4-prop-2-enylcyclopentane-1,3-dione；4-allylcyclopentane-1,3-dione；5-allyl-cyclopentan-1,3-dione
• CAS: 76779-05-0
• 化学式: C₈H₁₀O₂
• 分子量: 138.166
• InChiKey: NOONIXPOHUYFGS-UHFFFAOYSA-N

物化性质

• 沸点：
  239.6±28.0 °C(Predicted)
• 密度：
  1.055±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(2-丙烯基)-1,3-环戊二酮 生成 6-acetoxytricyclo<3.2.1.03,6>octan-2-one
  参考文献：
  名称：

  Intramolecular de Mayo reactions leading to zizaane and related terpencid ring systems

  摘要：

  DOI：

  10.1016/s0040-4039(00)78729-6
• 作为产物：
  描述：

  4-hydroxy-5-prop-2-enylcyclopent-2-en-1-one 在 aluminum oxide 、 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 4-(2-丙烯基)-1,3-环戊二酮
  参考文献：
  名称：

  Barker, Andrew J.; Pattenden, Gerald, Journal of the Chemical Society. Perkin transactions I, 1983, # 8, p. 1885 - 1891

  摘要：

  DOI：

文献信息

• Certain 1H-pyrrold[3,4-b]quinolin-1-one-9-amino-2,3-dihydro derivatives
  申请人：ICI Americas Inc.

  公开号：US04975435A1

  公开（公告）日：1990-12-04

  The present invention comprises certain quinoline lactams of formula I; pharmaceutically acceptable salts of the compounds of formula I; pharmaceutical compositions containing a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in the treatment of anxiety; and processes for the manufacture of the compounds of formula I, as well as intermediates for use in such manufacture.

  本发明涵盖了某些式I的喹啉内酰胺；式I化合物的药学上可接受的盐；含有式I化合物或其药学上可接受的盐的药物组合物，用于治疗焦虑；以及用于制造式I化合物的工艺，以及用于此类制造的中间体。
• Versatile desilylative cross-coupling of silyl enol ethers and allylic silanes via oxovanadium-induced chemoselective one-electron oxidation
  作者：Toshikazu Hirao、Takashi Fujii、Yoshiki Ohshiro

  DOI：10.1016/s0040-4020(01)81753-1

  日期：1994.8

  The chemoselective cross-coupling of silyl enol ethers and allylic silanes to γ,δ-unsaturated ketones is achieved by the oxovanadium (V)-induced oxidative desilylation of the more readily oxidizable organosilicon compounds.

  甲硅烷基烯醇醚和烯丙基硅烷与γ，δ-不饱和酮的化学选择性交叉偶联是通过氧钒酸（V）诱导的较易氧化的有机硅化合物的氧化脱甲硅基作用实现的。
• Certain fluorine substituted PGI.sub.2 compounds
  申请人：The University of Chicago

  公开号：US04324730A1

  公开（公告）日：1982-04-13

  Prostaglandin and prostacyclin compounds which are fluorine substituted in any one or more of the following positions, 4,4; 7,7; 10,10; and 5.

  前列腺素和前列环素化合物，其中在以下任何一个或多个位置上取代氟，包括4,4；7,7；10,10和5。
• Pyrazolopyridine cycloalkanone derivatives
  申请人：ICI AMERICAS INC.

  公开号：EP0141608A2

  公开（公告）日：1985-05-15

  Novel tetrahydropyrazolo-[3,4-b]quinolinones, cyclo- benta[b]pyrazolo-[4,3-e]pyridinones and cyclohepta[b]-pyraz- olo-[4,3-e]pyridinones are disclosed useful as anxiolytics hav- ng reduced side effects are disclosed, including methods of preparation, pharmaceutical compositions containing them and intermediates used in their preparation.

  公开了新型四氢吡唑并-[3,4-b]喹啉酮类、环庚并[b]吡唑并-[4,3-e]吡啶酮类和环庚并[b]吡唑并-[4,3-e]吡啶酮类抗焦虑药物，包括制备方法、含有这些药物的药物组合物以及用于制备这些药物的中间体。
• Synthesis of Tricyclic Aminopyridines by a Cadmium Promoted Cyclization
  作者：James B. Campbell、Judy W. Firor

  DOI：10.1021/jo00121a048

  日期：1995.8

  A novel cyclocondensation of o-amino nitriles with cyclic 1,3-diones has been developed as a synthetic route to assemble fused tricyclic aminopyridine derivatives. The reaction sequence involves the initial formation of an enaminone. The enaminone is then cyclized at 120 degrees C to 190 degrees C in the presence of Lewis acids which include zinc, cadmium and copper(I) salts. The cyclization may be promoted under more mild conditions by first deprotonating the enaminone to form the anion followed by exposure to cadmium(II) salts at 60 degrees C to 90 degrees C. Alternatively the enaminones may be reacted with organocadmium reagents such as dibutylcadmium to effect the deprotonation and cyclization directly at room temperature. Synthetic applications of these novel cadmium-mediated cyclizations are presented and mechanistic considerations discussed.