7-氨基-2-羟基-4-甲基-喹啉-6-磺酸 | 101872-02-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-氨基-2-羟基-4-甲基-喹啉-6-磺酸
• 英文名称: 7-amino-2-hydroxy-4-methyl-quinoline-6-sulfonic acid
• 英文别名: 7-Amino-2-hydroxy-4-methyl-chinolin-6-sulfonsaeure；7-amino-4-methyl-2-oxo-1H-quinoline-6-sulfonic acid
• CAS: 101872-02-0
• 化学式: C₁₀H₁₀N₂O₄S
• 分子量: 254.266
• InChiKey: FHIHUIUFGUGIQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  118
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  双乙烯酮 、 2,4-二氨基苯磺酸 在 水 作用下， 生成 7-氨基-2-羟基-4-甲基-喹啉-6-磺酸
  参考文献：
  名称：

  DE958647

  摘要：

  公开号：

文献信息

• Process for the preparation of 4-methyl-7-aminoquinolones
  申请人：Benkhoff Johannes

  公开号：US20050222397A1

  公开（公告）日：2005-10-06

  The present invention relates to a process for the preparation of a compound of the general formula (1), which comprises converting a compound of the general formula (II), in an aprotic organic solvent in the presence of a catalytically active amount of a strong acid (catalyst) or of an agent that liberates a strong acid or of an ammonium salt of a strong acid, it also being possible for the catalyst to be part of the starting material/product, into a compound of formula I, wherein R 5 , R 6 and R 8 are each independently of the others a hydrogen atom, a nitro group, a sulfo group, a halogen atom, a pseudohalogen, a group COOR 1 or CONHR 2 or a C 1-8 alkyl, C 1-8 alkoxy or aryloxy radical, an amide group, a thioalkyl or thioaryl radical, an alkyl- or aryl-sulfonyl radical, an alkyl- or aryl-sulfinyl radical, a trifluoromethyl group or a phosphono group, R 1 and R 2 being a hydrogen atom or a C 1-8 alkyl radical or an aryl or aralkyl radical, R 10 is a group —C(O)CH 2 C(O)CH 3 and R 11 is a hydrogen atom or an acyl radical, or R 10 and R 11 are a group —C(O)CH 2 C(O)CH 3 . The process according to the invention is simple to perform and results in products of high chemical purity and high isomeric purity in a high yield.

  本发明涉及一种通式(1)化合物的制备工艺，该工艺包括在有催化活性的强酸（催化剂）或释放出强酸的制剂或强酸的铵盐（催化剂也可以是起始原料/产物的一部分）存在的情况下，在非沸腾有机溶剂中将通式(II)化合物转化成式 I 的化合物，其中 R 5 , R 6 和 R 8 各自独立地为氢原子、硝基、磺基、卤素原子、假卤素、基团 COOR 1 或 CONHR 2 或 C 1-8 烷基，C 1-8 烷氧基或芳氧基、酰胺基、硫代烷基或硫代芳基、烷基或芳基磺酰基、 烷基或芳基亚磺酰基、三氟甲基或磷酰基，R 1 和 R 2 是氢原子或 C 1-8 烷基或芳基或芳烷基，R 10 是一个基团 -C(O)CH 2 C(O)CH 3 和 R 11 是氢原子或酰基，或 R 10 和 R 11 是一个基团 -C(O)CH 2 C(O)CH 3 .本发明的工艺操作简单，可生产出高化学纯度和高异构纯度的高产率产品。
• PROCESS FOR THE PREPARATION OF 4-METHYL-7-AMINOQUINOLONES
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP1453809A1

  公开（公告）日：2004-09-08
• US7144993B2
  申请人：——

  公开号：US7144993B2

  公开（公告）日：2006-12-05
• [EN] PROCESS FOR THE PREPARATION OF 4-METHYL-7-AMINOQUINOLONES<br/>[FR] METHODE DE PREPARATION DE 4-METHYL-7-AMINOQUINOLONES
  申请人：CIBA SC HOLDING AG

  公开号：WO2003050089A1

  公开（公告）日：2003-06-19

  The present invention relates to a process for the preparation of a compound of the general formula (I), which comprises converting a compound of the general formula (II), in an aprotic organic solvent in the presence of a catalytically active amount of a strong acid (catalyst) or of an agent that liberates a strong acid or of an ammonium salt of a strong acid, it also being possible for the catalyst to be part of the starting material/product, into a compound of formula I, wherein R?5, R6 and R8¿ are each independently of the others a hydrogen atom, a nitro group, a sulfo group, a halogen atom, a pseudohalogen, a group COOR1 or CONHR2 or a C¿1-8? alkyl, C1-8 alkoxy or aryloxy radical, an amide group, a thioalkyl or thioaryl radical, an alkyl- or aryl-sulfonyl radical, an alkyl- or aryl-sulfinyl radical, a trifluoromethyl group or a phosphono group, R?1 and R2¿ being a hydrogen atom or a C¿1-8? alkyl radical or an aryl or aralkyl radical, R?10¿ is a group -C(O)CH¿2?C(O)CH3 and R?11¿ is a hydrogen atom or an acyl radical, or R?10 and R11¿ are a group -C(O)CH¿2?C(O)CH3. The process according to the invention is simple to perform and results in products of high chemical purity and high isomeric purity in a high yield.
• DE958647
  申请人：——

  公开号：——

  公开（公告）日：——