D-ribonic acid-(3.4-dimethyl-anilide) | 64339-92-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-ribonic acid-(3.4-dimethyl-anilide)
• 英文别名: D-ribo-2.3.4.5-Tetrahydroxy-valeriansaeure-(3.4-dimethyl-anilid)；D-Ribonsaeure-(3.4-dimethyl-anilid)；(2R,3R,4R)-N-(3,4-dimethylphenyl)-2,3,4,5-tetrahydroxypentanamide
• CAS: 64339-92-0
• 化学式: C₁₃H₁₉NO₅
• 分子量: 269.298
• InChiKey: QNRFMBRRBOYLJH-IJLUTSLNSA-N

物化性质

• 沸点：
  629.0±55.0 °C(Predicted)
• 密度：
  1.375±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  D-ribonic acid-(3.4-dimethyl-anilide) 在 吡啶 、 palladium-barium carbonate 、 氯仿 、 五氯化磷 、 乙酸乙酯 作用下， 生成 L-ribo-5-(3.4-dimethyl-anilino)-1.2.3.4-tetraacetoxy-pentane
  参考文献：
  名称：

  A Methodology for Reducing Respondent Duplication and Impersonation in Samples of Hidden Populations

  摘要：

  研究人员在对隐藏人群（如注射毒品者）进行抽样调查并使用财务激励来招募受访者时会遇到一个困境。为了防止受访者重复参与研究（同一受访者使用不同身份多次参与研究）和受访者冒充（一个受访者冒用其他受访者的身份），研究人员必须确认受访者的身份。然而，文件化方法会引入采样偏倚，对那些缺乏身份证明或希望保持匿名的人造成不利影响。确凿的身份识别形式（如摄影和指纹）会对人群中更加不信任的成员产生偏见，而基于扫描仪的生物特征识别可能成本高昂。因此，大多数研究项目依赖工作人员识别先前的受访者，但工作人员流动和大量受访者会影响准确性。我们描述并定量评估了一种基于统计原理的主体识别方法的准确性，即指标的可互换性，即多个弱指标结合形成更强的综合度量。分析表明，身份的可观察指标（疤痕、胎记、纹身、眼睛颜色、种族和性别）以及五个生物测量（身高、前臂长度和腕围）为主体识别提供了可靠且易于管理的基础方法。

  DOI：

  10.1177/002204260103100209
• 作为产物：
  描述：

  3,4-二甲基苯胺 、 D-(+)-核糖酸-1,4-内酯 在 对苯二酚 作用下， 生成 D-ribonic acid-(3.4-dimethyl-anilide)
  参考文献：
  名称：

  A Methodology for Reducing Respondent Duplication and Impersonation in Samples of Hidden Populations

  摘要：

  研究人员在对隐藏人群（如注射毒品者）进行抽样调查并使用财务激励来招募受访者时会遇到一个困境。为了防止受访者重复参与研究（同一受访者使用不同身份多次参与研究）和受访者冒充（一个受访者冒用其他受访者的身份），研究人员必须确认受访者的身份。然而，文件化方法会引入采样偏倚，对那些缺乏身份证明或希望保持匿名的人造成不利影响。确凿的身份识别形式（如摄影和指纹）会对人群中更加不信任的成员产生偏见，而基于扫描仪的生物特征识别可能成本高昂。因此，大多数研究项目依赖工作人员识别先前的受访者，但工作人员流动和大量受访者会影响准确性。我们描述并定量评估了一种基于统计原理的主体识别方法的准确性，即指标的可互换性，即多个弱指标结合形成更强的综合度量。分析表明，身份的可观察指标（疤痕、胎记、纹身、眼睛颜色、种族和性别）以及五个生物测量（身高、前臂长度和腕围）为主体识别提供了可靠且易于管理的基础方法。

  DOI：

  10.1177/002204260103100209

文献信息

• Forrest et al., Journal of the Chemical Society, 1952, p. 2530,2534
  作者：Forrest et al.

  DOI：——

  日期：——
• 40. Synthetic experiments in the B group of vitamins. Part I. Riboflavin
  作者：F. Bergel、A. Cohen、J. W. Haworth

  DOI：10.1039/jr9450000165

  日期：——
• US2411611
  申请人：——

  公开号：——

  公开（公告）日：——
• Haworth, Barell-Festschr. <Basel 1946>S.70
  作者：Haworth

  DOI：——

  日期：——
• An Investigation of Airway Wound Healing Using a Novel in vivo Model
  作者：Jose Hardillo、Christoph Vanclooster、Pierre R. Delaere

  DOI：10.1097/00005537-200107000-00009

  日期：2001.7

  AbstractObjective To study the amount of wound contraction and reepithelialization occurring in the healing process of full‐thickness mucosal defects treated with and without mitomycin.Study Design A new wound healing model was developed in which the tracheal mucosa was exteriorized without interference with the blood supply or with the cartilage support of the trachea. This was done by: 1) orthotopic tracheal revascularization in vascularized fascia; 2) isolation of revascularized segment after 14 days; 3) posterior longitudinal incision of revascularized segment; 4) exteriorization of tracheal mucosa with formation of anterior full‐thickness mucosal defect; and 5) closure of posterior tracheal incision and reimplantation in the airway. This model was used to study airway wound healing in three groups of animals: 1) controls (revascularization, exteriorization, reimplantation) (N = 6); 2) full‐thickness mucosal defect: patch defect (N = 5), circumferential defect (N = 3); and 3) full‐thickness mucosal defect after topical mitomycin application: patch defect (N = 7), circumferential defect (N = 3). The animals were followed for periods varying from 2 to 4 weeks or until signs of dyspnea. The surface areas of the wounds before and after follow‐up were measured. Wound healing was studied histologically on axial and longitudinal sections.Results Group 1: All the animals survived for 1 month. No significant difference existed between surface area of isolated trachea and of reimplanted trachea after follow‐up. Group 2: Five animals (patch defects) survived for 1 month. Full‐thickness mucosal defects healed by reepithelialization and by a surface area reduction of 58.9% (mean ‐ standard deviation = 10.5). The animals with the circumferential defects showed dyspnea after an average follow‐up of 14 days as a result of excessive granulation tissue formation. Group 3: Mitomycin reproducibly inhibited wound closure, yielding wounds that on average closed 56% less than controls by day 14 (P <.001). Histologic comparisons showed that mitomycin blocks angiogenesis during wound healing.Conclusions A wound healing model based on tracheal revascularization, isolation, and reimplantation was developed in rabbits. This model allowed us to study the healing of full‐thickness mucosal defects inside the airway.