ethyl 3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazole-5-carboxylate | 1357157-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazole-5-carboxylate
• CAS: 1357157-83-5
• 化学式: C₁₈H₂₄ClN₃O₂
• 分子量: 349.86
• InChiKey: CKTFLBYLKHQDDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.72
• 重原子数：
  24.0
• 可旋转键数：
  8.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  47.36
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  ethyl 3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazole-5-carboxylate 在 lithium aluminium tetrahydride 、 氢化钾 作用下， 以 四氢呋喃 为溶剂， 反应 4.17h， 生成 tert-butyl 2-((3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazol-5-yl)methoxy)acetate
  参考文献：
  名称：

  Design and Synthesis of Novel Pyrazole-based Lp-PLA2 Inhibitors

  摘要：

  AbstractA series of novel pyrazole‐based lipoprotein‐associated phospholipase A2 (Lp‐PLA2) inhibitors have been designed and synthetized by a variety of acetophenones via a 10‐step convergent approach. The synthetic approach is carefully optimized, and an unsuccessful alternative route is also discussed. The in vitro biological activity reveals that all the synthesized compounds are potent Lp‐PLA2 inhibitors with compound 13b being the most potent one (Lp‐PLA2, IC50=1.5 nmol/L).

  DOI：

  10.1002/cjoc.201180354
• 作为产物：
  描述：

  对氯苯乙酮 在 乙醇 、 sodium 、 potassium carbonate 、 一水合肼 、 溶剂黄146 、 potassium iodide 作用下， 以 水 、 乙腈 为溶剂， 反应 14.01h， 生成 ethyl 3-(4-chlorophenyl)-1-(2-(diethylamino)ethyl)-1H-pyrazole-5-carboxylate
  参考文献：
  名称：

  Design and Synthesis of Novel Pyrazole-based Lp-PLA2 Inhibitors

  摘要：

  AbstractA series of novel pyrazole‐based lipoprotein‐associated phospholipase A2 (Lp‐PLA2) inhibitors have been designed and synthetized by a variety of acetophenones via a 10‐step convergent approach. The synthetic approach is carefully optimized, and an unsuccessful alternative route is also discussed. The in vitro biological activity reveals that all the synthesized compounds are potent Lp‐PLA2 inhibitors with compound 13b being the most potent one (Lp‐PLA2, IC50=1.5 nmol/L).

  DOI：

  10.1002/cjoc.201180354