3-(溴甲基)-2,6-二甲氧基吡啶 | 934286-66-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-(溴甲基)-2,6-二甲氧基吡啶
• 英文名称: 3-(Bromomethyl)-2,6-dimethoxypyridine
• CAS: 934286-66-5
• 化学式: C₈H₁₀BrNO₂
• 分子量: 232.077
• InChiKey: CGZARUONTNTXET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  3-(溴甲基)-2,6-二甲氧基吡啶 在 sodium hydride 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 20.0h， 生成 (Z)-3-(3-((tert-butyldimethylsilyl)oxy)-4-methoxystyryl)-2,6-dimethoxypyridine
  参考文献：
  名称：

  Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents

  摘要：

  A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2,6-dimethoxypyridine-3-yl)-9-ethyl and 9-methylcarbazole-3-sulfonamide (13 and 14) gave significant cytotoxicity (IC50 = 122 and 101 nM). Compound 13 displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides which includes the influence of azaheterocycle rings, sulfonamide linkage, and the carbazole ring are described.

  DOI：

  10.1016/j.bmcl.2006.12.034
• 作为产物：
  描述：

  3-溴-2,6-二甲氧基吡啶 在 sodium tetrahydroborate 、 正丁基锂 、 三溴化磷 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 17.0h， 生成 3-(溴甲基)-2,6-二甲氧基吡啶
  参考文献：
  名称：

  Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents

  摘要：

  A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2,6-dimethoxypyridine-3-yl)-9-ethyl and 9-methylcarbazole-3-sulfonamide (13 and 14) gave significant cytotoxicity (IC50 = 122 and 101 nM). Compound 13 displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides which includes the influence of azaheterocycle rings, sulfonamide linkage, and the carbazole ring are described.

  DOI：

  10.1016/j.bmcl.2006.12.034

文献信息

• Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents
  作者：Laixing Hu、Zhuo-rong Li、Yue-ming Wang、Yanbin Wu、Jian-Dong Jiang、David W. Boykin

  DOI：10.1016/j.bmcl.2006.12.034

  日期：2007.3

  A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2,6-dimethoxypyridine-3-yl)-9-ethyl and 9-methylcarbazole-3-sulfonamide (13 and 14) gave significant cytotoxicity (IC50 = 122 and 101 nM). Compound 13 displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides which includes the influence of azaheterocycle rings, sulfonamide linkage, and the carbazole ring are described.