3-(2,3,4-trimethoxy-6-methylbenzoyl)-4,5-dichloro-2-methoxypyridine | 688046-43-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2,3,4-trimethoxy-6-methylbenzoyl)-4,5-dichloro-2-methoxypyridine
• 英文别名: (4,5-Dichloro-2-methoxy-3-pyridinyl)(2,3,4-trimethoxy-6-methylphenyl)methanone；(4,5-dichloro-2-methoxypyridin-3-yl)-(2,3,4-trimethoxy-6-methylphenyl)methanone
• CAS: 688046-43-7
• 化学式: C₁₇H₁₇Cl₂NO₅
• 分子量: 386.232
• InChiKey: SXEDMKXHMMJEPN-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于氯仿、乙醚、甲苯

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(2,3,4-trimethoxy-6-methylbenzoyl)-4,5-dichloro-2-methoxypyridine 、 三甲基环三硼氧烷 在 四(三苯基膦)钯 potassium carbonate 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 10.0h， 以75%的产率得到pyriofenone
  参考文献：
  名称：

  EP1559320

  摘要：

  公开号：
• 作为产物：
  描述：

  (2,3,4-trimethoxy-6-methylphenyl)(4,5-dichloro-2-methoxy-3-pyridyl)methanol 在 manganese dioxide manganese dioxide 、 甲苯 、 silica gel 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以to obtain 2.98 g (yield: 65%) of 3-(2,3,4-trimethoxy-6-methylbenzoyl)-4,5-dichloro-2-methoxypyridine的产率得到3-(2,3,4-trimethoxy-6-methylbenzoyl)-4,5-dichloro-2-methoxypyridine
  参考文献：
  名称：

  FUNGICIDAL COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASES

  摘要：

  一种杀真菌组合物，包含以下活性成分：（a）苯甲酰吡啶衍生物，其化学式或其盐表示如下：其中X是卤素原子、硝基、可替换的碳氢基团、可替换的烷氧基团、可替换的芳氧基团、可替换的环烷氧基团、羟基、可替换的烷硫基团、氰基、羧基（可以酯化或酰胺化）或可替换的氨基团，n为1、2、3或4；R1是可替换的烷基团，R2'是可替换的烷基团、可替换的烷氧基团、可替换的芳氧基团、可替换的环烷氧基团或羟基，p为1、2或3，R2"是可替换的烷氧基团或羟基，但至少有两个R2'和R2"可以选择性地形成含氧原子的紧缩环；（b）至少另外一种杀真菌剂。

  公开号：

  US20140107138A1

文献信息

• 3-benzoyl-2,4,5-substituted pyridine derivatives or salts thereof and bactericides containing the same
  申请人：Nishide Hisaya

  公开号：US20060089390A1

  公开（公告）日：2006-04-27

  To provide 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, fungicides containing them, and intermediates for producing them. By providing a group of compounds comprising specific 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, or fungicides containing them, which have so-called rainfastness, whereby they are capable of exhibiting excellent effects even when crops have received rainfall after application of the chemicals, it becomes unnecessary to increase the number of applications or the dose of the chemicals by taking into consideration the rainfall after the application of the chemicals. Thus, it is possible to protect crops from disease injuries at a lower cost with less labor.

  提供3-苯甲酰基-2,4,5-取代吡啶衍生物或其盐，含有它们的杀菌剂以及用于生产它们的中间体。通过提供一组化合物，其中包括特定的3-苯甲酰基-2,4,5-取代吡啶衍生物或其盐，或含有它们的杀菌剂，这些化合物具有所谓的雨水稳定性，即使作物在化学品施用后遭受降雨，它们仍能展现出优异的效果，因此不必考虑化学品施用后的降雨增加化学品的施用次数或剂量。因此，可以以更低的成本和更少的劳动力保护作物免受病害的伤害。
• FUNGICIDAL COMPOSITION AND METHOD FOR CONTROLLING PLANT DISEASES
  申请人：NISHIDE Hisaya

  公开号：US20090247763A1

  公开（公告）日：2009-10-01

  It is to provide a fungicidal composition having stable and high fungicidal effects against cultivated crops infected with plant diseases resulting from plant diseases. A fungicidal composition containing as active ingredients (a) a benzoylpyridine derivative represented by the formula (I) or its salt: (wherein X is a halogen atom, a nitro group, a substitutable hydrocarbon group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group, a hydroxyl group, a substitutable alkylthio group, a cyano group, a carboxyl group which may be esterified or amidated, or a substitutable amino group, n is 1, 2, 3 or 4; R 1 is a substitutable alkyl group, R 2′ is a substitutable alkyl group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group or a hydroxyl group, a is 1, 2 or 3, and R 2″ is a substitutable alkoxy group or a hydroxyl group, provided that at least two of R 2′ and R 2″ may form a condensed ring containing an oxygen atom) and (b) at least one another fungicide.

  提供一种杀菌组合物，对由植物疾病引起的种植作物感染的植物疾病具有稳定和高效的杀菌效果。该杀菌组合物包含以下活性成分：(a)一种由式(I)表示的苯甲酰吡啶衍生物或其盐：(其中X为卤素原子、硝基、可替换的碳氢基、可替换的烷氧基、可替换的芳氧基、可替换的环烷氧基、羟基、可替换的烷硫基、氰基、可酯化或酰胺化的羧基或可替换的氨基，n为1、2、3或4；R1为可替换的烷基，R2'为可替换的烷基、可替换的烷氧基、可替换的芳氧基、可替换的环烷氧基或羟基，a为1、2或3，R2''为可替换的烷氧基或羟基，但至少有R2'和R2''中的两个可以形成含氧原子的缩环)和(b)至少另一种杀菌剂。
• 3-BENZOYL-2,4,5-SUBSTITUTED PYRIDINE DERIVATIVES OR SALTS THEREOF AND BACTERICIDES CONTAINING THE SAME
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP1559320A1

  公开（公告）日：2005-08-03

  To provide 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, fungicides containing them, and intermediates for producing them. By providing a group of compounds comprising specific 3-benzoyl-2,4,5-substituted pyridine derivatives or their salts, or fungicides containing them, which have so-called rainfastness, whereby they are capable of exhibiting excellent effects even when crops have received rainfall after application of the chemicals, it becomes unnecessary to increase the number of applications or the dose of the chemicals by taking into consideration the rainfall after the application of the chemicals. Thus, it is possible to protect crops from disease injuries at a lower cost with less labor.

  提供 3-苯甲酰基-2,4,5-取代的吡啶衍生物或它们的盐、含有它们的杀菌剂以及生产它们的中间体。 通过提供由特定的 3-苯甲酰基-2,4,5-取代的吡啶衍生物或其盐组成的一组化合物，或含有它们的杀真菌剂，它们具有所谓的耐雨性，即即使在施用药剂后作物受到降雨的影响，它们也能表现出优异的效果，因此无需考虑施用药剂后的降雨情况而增加施用次数或药剂剂量。因此，可以用较低的成本和较少的劳动力保护作物免受病害的伤害。
• ANTIBACTERIAL COMPOSITION AND METHOD FOR CONTROL OF PLANT DISEASE
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP2036436A1

  公开（公告）日：2009-03-18

  To provide a fungicidal composition having stable and high preventive effects against crops infected with plant diseases. A fungicidal composition containing as active ingredients (a) a benzoylpyridine derivative represented by the formula (I) or its salt: (wherein X is a halogen atom, a nitro group, a substitutable hydrocarbon group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group, or the like; n is 1, 2, 3 or 4; R1 is a substitutable alkyl group; R2' is a substitutable alkyl group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group or a hydroxyl group; p is 1, 2 or 3; and R2" is a substitutable alkoxy group or a hydroxyl group, provided that at least two of R2' and R2" may form a condensed ring containing an oxygen atom) and at least one member selected from the group consisting eight types of an activity-enhancing ingredient (b).

  提供一种对感染植物病害的作物具有稳定和高预防效果的杀菌组合物。 一种杀菌组合物，其活性成分包括 (a) 由式（I）表示的苯甲酰吡啶衍生物或其盐： (其中 X 是卤素原子、硝基、可被取代的烃基、可被取代的烷氧基、可被取代的芳氧基、可被取代的环烷氧基或类似基团；n 是 1、2、3 或 4；R1 是可被取代的烷基；R2'是可被取代的烷基、可被取代的烷氧基、可被取代的芳氧基、可被取代的环烷氧基或羟基；p为 1、2 或 3；R2 "为可被取代的烷氧基或羟基，条件是 R2'和 R2 "中至少有两个可形成含有一个氧原子的缩合环）和至少一种选自八种活性增强成分（b）的成员。
• Preparation of fungicidal benzoylpyridine derivatives
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：EP2338335A1

  公开（公告）日：2011-06-29

  A process for producing a benzoylpyridine derivative represented by the following formula (I) or its salt: (wherein X is a halogen atom, a nitro group, a substitutable hydrocarbon group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group, a hydroxyl group, a substitutable alkylthio group, a cyano group, a carboxyl group which may be esterified or amidated, or a substitutable amino group; n is 1, 2, 3 or 4; R' is a substitutable alkyl group; R2' is a substitutable alkyl group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group or a hydroxyl group; p is 1, 2 or 3; and R2" is a substitutable alkoxy group or a hydroxyl group; wherein at least two of R2' and R2" may form a condensed ring containing an oxygen atom); characterized by reacting a compound represented by the formula (XIII): (wherein X and n are as defined above) with a compound represented by the formula (XIV): (wherein R1, R2', R2" and p are as defined above) in the presence of a Lewis acid or a dehydrating agent.

  一种生产下式 (I) 所代表的苯甲酰吡啶衍生物或其盐的工艺： (其中 X 是卤原子、硝基、可被取代的烃基、可被取代的烷氧基、可被取代的芳氧基、可被取代的环烷氧基、羟基、可被取代的烷硫基、氰基、可被酯化或酰胺化的羧基或可被取代的氨基；n 是 1、2、3 或 4；R'是可被取代的烷基；R2'是可被取代的烷基、可被取代的烷氧基、可被取代的芳氧基、可被取代的环烷氧基或羟基；p 是 1、2 或 3；R2 "是可被取代的烷氧基或羟基；其中至少两个 R2'和 R2 "可形成含有一个氧原子的缩合环）； 其特征是使式 (XIII) 所代表的化合物发生反应： 式(XIII)代表的化合物(其中X和n如上定义)与式(XIV)代表的化合物反应： (其中 R1、R2'、R2 "和 p 如上定义）的化合物在路易斯酸或脱水剂存在下反应。