10-Undec-10-ynylacridin-9-one | 188584-13-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-Undec-10-ynylacridin-9-one
• CAS: 188584-13-6
• 化学式: C₂₄H₂₇NO
• 分子量: 345.484
• InChiKey: JHNDRBIOOKPWPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  10-Undec-10-ynylacridin-9-one 在 四(三苯基膦)钯 、 N-benzoyl(4-O-trifluoromethanesulfonyl)-L-phenylalanine methyl ester 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以33%的产率得到
  参考文献：
  名称：

  Palladium-catalysed attachment of labels with acetylenic linker arms to biological molecules

  摘要：

  Palladium-catalysed coupling has been used to attach a series of fluorescent (acridonyl, pyrenyl, fluoresceinyl, dansyl and ruthenium phenanthrolinyl) and enzymic (biotinyl) labels containing a terminal alkyne to electophilic biological molecules based on amino acids, nucleosides and steroids. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(96)01085-x
• 作为产物：
  描述：

  undec-10-yn-1-yl methanesulfonate 在 氢氧化钾 、 苄基三乙基氯化铵 、 sodium iodide 作用下， 以 丁酮 为溶剂， 反应 29.0h， 生成 10-Undec-10-ynylacridin-9-one
  参考文献：
  名称：

  Preparation of biological labels with acetylenic linker arms

  摘要：

  The preparation of a series of fluorescent labels based on acridone, pyrene, fluorescein, dimedlylaminonaphthalenesulphonamide and tris-l,10-phenanthroline ruthenium and an enzymic label based on biotin with spacers containing a terminal acetylene is described. (C) 1997, Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(96)01084-8

文献信息

• Preparation of biological labels with acetylenic linker arms
  作者：Geoffrey T. Crisp、Jeffrey Gore

  DOI：10.1016/s0040-4020(96)01084-8

  日期：1997.1

  The preparation of a series of fluorescent labels based on acridone, pyrene, fluorescein, dimedlylaminonaphthalenesulphonamide and tris-l,10-phenanthroline ruthenium and an enzymic label based on biotin with spacers containing a terminal acetylene is described. (C) 1997, Elsevier Science Ltd.
• Palladium-catalysed attachment of labels with acetylenic linker arms to biological molecules
  作者：Geoffrey T. Crisp、Jeffrey Gore

  DOI：10.1016/s0040-4020(96)01085-x

  日期：1997.1

  Palladium-catalysed coupling has been used to attach a series of fluorescent (acridonyl, pyrenyl, fluoresceinyl, dansyl and ruthenium phenanthrolinyl) and enzymic (biotinyl) labels containing a terminal alkyne to electophilic biological molecules based on amino acids, nucleosides and steroids. (C) 1997, Elsevier Science Ltd.