dimethylhydroxylamine hydrochloride | 159581-86-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimethylhydroxylamine hydrochloride
• 英文别名: MeONHOMe hydrochloride；(Methoxyamino)oxymethane;hydrochloride；(methoxyamino)oxymethane;hydrochloride
• CAS: 159581-86-9
• 化学式: C₂H₇NO₂*ClH
• 分子量: 113.544
• InChiKey: PRJHDVZYWLTOOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.12
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-氟吲哚-2-甲酸 、 dimethylhydroxylamine hydrochloride 在 1-羟基苯并三唑 、 1,2-二氯乙烷 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Discovery of N-Aryl-2-acylindole human glucagon receptor antagonists

  摘要：

  A novel class of N-aryl-2-acylindole human glucagon receptor (hGCGR) antagonists is reported. These compounds demonstrate good pharmacokinetic profiles in multiple preclinical species. One compound from this series, indole 33, is orally active in a transgenic murine pharmacodynamic model. Furthermore, a 1 mg/kg oral dose of indole 33 lowers ambient glucose levels in an ob/ob/hGCGR transgenic murine diabetes model. This compound was deemed suitable for preclinical safety studies and was found to be well tolerated in an 8-day experimental rodent tolerability study. The combination of preclinical efficacy and safety observed with compound 33 highlights the potential of this class as a treatment for type 2 diabetes. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.09.105

文献信息

• XL-Xantphos: Design and Synthesis of a Mechanistic Probe of Xantphos <i>O</i>-Coordination in Catalytic Reactions
  作者：Gregory T. Whiteker、Fangzheng Li、Robert D. J. Froese、Michael L. Tulchinsky、Amaruka Hazari、Jerzy Klosin

  DOI：10.1021/acs.organomet.9b00141

  日期：2019.5.13

  The synthesis and characterization of an analog of the Xantphos ligand that is geometrically incapable of coordination of the xanthene bridging oxygen atom is reported. This new ligand, XL-Xantphos, ((9,9-dimethyl-9H-xanthene-4,5-diyl)bis(4,1-phenylene))bis(diphenylphosphane), was studied in homogeneous, catalytic reactions for comparison with Xantphos. The XL-Xantphos ligand performed essentially

  据报道，Xantphos配体的类似物的合成和表征在几何上不能与氧杂蒽酮桥接氧原子配位。这种新的配体XL-Xantphos（（（9,9-dimethyl-9 H-Xanthene-4,5-diyl）bis（4,1-phenylene）bis（diphenylphosphane）在均相催化反应中进行了研究，以与Xantphos进行比较。XL-Xantphos配体在Rh催化的1-辛烯加氢甲酰化反应中与Xantphos基本相同，这表明对线性醛的高区域选择性是由于这些配体的大咬合角而不受氧与金属的配位影响。类似地，在Xantphos和XL-Xantphos之间，Pd催化的4-溴茴香醚与二甲基羟胺盐酸盐的酰胺羰基化反应没有差异。在理论上的DLPNO–CCSD（T）水平上对Pd（II）膦配合物的计算表明，这些配体对顺式和反式具有不同的偏好协调模式。XL-Xantphos配体对反式螯合结构具有热力学偏好，而顺式-[（Xantphos）PdCl
• Discovery of N-Aryl-2-acylindole human glucagon receptor antagonists
  作者：Christopher Sinz、Amy Bittner、Ed Brady、Mari Candelore、Qing Dallas-Yang、Victor Ding、Guoqiang Jiang、Zhen Lin、Sajjad Qureshi、Gino Salituro、Richard Saperstein、Jackie Shang、Deborah Szalkowski、Laurie Tota、Stella Vincent、Michael Wright、Shiyao Xu、Xiaodong Yang、Bei Zhang、James Tata、Ronald Kim、Emma R. Parmee

  DOI：10.1016/j.bmcl.2011.09.105

  日期：2011.12

  A novel class of N-aryl-2-acylindole human glucagon receptor (hGCGR) antagonists is reported. These compounds demonstrate good pharmacokinetic profiles in multiple preclinical species. One compound from this series, indole 33, is orally active in a transgenic murine pharmacodynamic model. Furthermore, a 1 mg/kg oral dose of indole 33 lowers ambient glucose levels in an ob/ob/hGCGR transgenic murine diabetes model. This compound was deemed suitable for preclinical safety studies and was found to be well tolerated in an 8-day experimental rodent tolerability study. The combination of preclinical efficacy and safety observed with compound 33 highlights the potential of this class as a treatment for type 2 diabetes. (C) 2011 Elsevier Ltd. All rights reserved.