carbonic acid 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl ester ethyl ester | 859214-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: carbonic acid 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl ester ethyl ester
• CAS: 859214-76-9
• 化学式: C₂₁H₃₂O₅Si
• 分子量: 392.568
• InChiKey: ZJLBLKFIBLEEBL-GBESFXJTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.25
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  53.99
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  carbonic acid 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl ester ethyl ester 在 (S,S)-DACH-phenyl Trost ligand 、 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 吡啶 、 PS-diethylenetriamine 、 四丁基氟化铵 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 二氯甲烷 、 乙腈 为溶剂， 反应 14.25h， 生成 O-[[(2R,3S,6S)-3-(4-methoxyphenoxy)-6-phenyl-3,6-dihydro-2H-pyran-2-yl]methyl]hydroxylamine
  参考文献：
  名称：

  Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling

  摘要：

  yThe synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.

  DOI：

  10.1021/ol051023r
• 作为产物：
  描述：

  6-O-(叔丁基二甲基硅烷基)-D-葡萄烯糖 在 palladium diacetate 吡啶 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 carbonic acid 2-(tert-butyl-dimethyl-silanyloxymethyl)-6-phenyl-3,6-dihydro-2H-pyran-3-yl ester ethyl ester
  参考文献：
  名称：

  Convergent Synthesis of a Complex Oxime Library Using Chemical Domain Shuffling

  摘要：

  yThe synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive.

  DOI：

  10.1021/ol051023r