甲基(4S)-2-氧代-4-[(2E)-1-氧代-2-丁烯-2-基]-3,4-二氢-2H-吡喃-5-羧酸酯 | 24582-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 甲基(4S)-2-氧代-4-[(2E)-1-氧代-2-丁烯-2-基]-3,4-二氢-2H-吡喃-5-羧酸酯
• 中文别名: 油橄榄内酯
• 英文名称: elenolide
• 英文别名: S-Elenolid；methyl (4S)-2-oxo-4-[(E)-1-oxobut-2-en-2-yl]-3,4-dihydropyran-5-carboxylate
• CAS: 24582-91-0
• 化学式: C₁₁H₁₂O₅
• 分子量: 224.213
• InChiKey: TXTINTVPMBCGKO-PFPYCLJUSA-N

物化性质

• 熔点：
  155.5°
• 比旋光度：
  D20 +369° (chloroform)
• 沸点：
  384.2±42.0 °C(Predicted)
• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Iridoid Based Formulations
  申请人：West Brett Justin

  公开号：US20110217394A1

  公开（公告）日：2011-09-08

  Embodiments of the invention relate to fortified food and dietary supplement products which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with plant products and iridoids.
• Acai and Iridoid Based Formulations
  申请人：West Brett Justin

  公开号：US20110206786A1

  公开（公告）日：2011-08-25

  Embodiments of the invention relate to fortified food and dietary supplement products, which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relate to the administration of products enhanced with Acai and iridoids.
• Morinda Citrifolia and Iridoid Based Formulations
  申请人：West Brett Justin

  公开号：US20110206787A1

  公开（公告）日：2011-08-25

  Embodiments of the invention relate to fortified food and dietary supplement products which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with Morinda citrifolia and iridoids.
• Garcinia Mangostana L. and Iridoid Based Formulations
  申请人：West Brett Justin

  公开号：US20120021079A1

  公开（公告）日：2012-01-26

  Embodiments of the invention relate to fortified food and dietary supplement products, which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relate to the administration of products enhanced with Garcinia mangostana L. and iridoids.
• Morinda Citrifolia Juice Formulations Comprising Iridoids
  申请人：West Brett Justin

  公开号：US20150086655A1

  公开（公告）日：2015-03-26

  Embodiments of the invention relate to fortified food and dietary supplement products which may be administered to produce desirable physiological improvement. In particular, embodiments of the invention relates to the administration of products enhanced with plant products and iridoids. A study was performed to evaluate the iridoid content, as well as the in vitro and in vivo bioactivities, of a beverage containing noni fruit, Cornelian cherries, and olive leaf extract. The major iridoids present were identified as asperulosidic acid, deacetylasperulosidic acid, oleuropein, morroniside, loganic acid, and loganin In the 2,2-Diphenylpicrylhydrazyl (DPPH) radical scavenging assay, remarkably high in vitro antioxidant activity was observed, with an IC 50 of 3.8 μL/mL. In vivo bioactivities were evaluated in type 2 diabetic Sprague Dawley rats. In a dose-dependent manner, the composition reduced abnormal weight gain, blood glucose levels, and serum advanced glycation end products (AGEs), as well as improved immunity via increased T cell counts and CD4+/CD8 + ratios.