木糖酸二钠盐 | 10158-64-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 木糖酸二钠盐
• 英文名称: 4-Oxo-4H-pyran-3-acetic acid
• 英文别名: (4-oxo-4H-pyran-3-yl)-acetic acid；2-(4-pyronyl)acetic acid；Xylaric acid；2-(4-oxopyran-3-yl)acetic acid
• CAS: 10158-64-2
• 化学式: C₇H₆O₄
• 分子量: 154.122
• InChiKey: OIYFAQRHWMVENL-UHFFFAOYSA-N

物化性质

• 熔点：
  150-151 °C
• 沸点：
  685.0±55.0 °C(Predicted)
• 密度：
  1.916±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于酸性水溶液（轻微）、水（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

上下游信息

• 下游产品

  中文名称	英文名称	CAS号	化学式	分子量
  ——	methyl 4-oxo-4H-pyran-3-acetate	——	C8H8O4	168.149

反应信息

• 作为反应物：
  描述：

  木糖酸二钠盐 在 重氮甲烷 作用下， 以 甲醇 、 乙醚 为溶剂， 以48%的产率得到methyl 4-oxo-4H-pyran-3-acetate
  参考文献：
  名称：

  Bioactivity studies of oxysporone and several derivatives

  摘要：

  Recently oxysporone, a phytotoxic dihydrofuropyranone, was isolated along with two closely related compounds, afritoxinones A and B, from liquid cultures of Diplodia africana, an invasive fungal pathogen of Phoenicean juniper. In this study, eight derivatives were hemisynthesized and assayed for their phytotoxic and antifungal activities in comparison to the parent compound. Each compound was tested on non-host plants and on four destructive plant pathogens such as Athelia rolfsii, Diplodia corticola, Phytophthora cinnamomi and P. plurivora. The results on the phytotoxic activity showed that the dihydrofuropyranone carbon skeleton and both the double bond the hydroxy group of dihydropyran ring appeared to be structural features important in conferring activity. Although the data concerning the antifungal activity did not allow to extract any structure-activity relationships, it should be underlined that the conversion of oxysporone into the corresponding 4-O-benzoyl derivative led to a compound showing a good antifungal activity towards three out of the four organisms tested. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.phytol.2014.07.005
• 作为产物：
  描述：

  (3aR,4S,7aR)-4-羟基-3,3a,4,7a-四氢呋喃并[5,4-b]吡喃-2-酮 在 Jones reagent 作用下， 以 丙酮 为溶剂， 反应 0.17h， 以40%的产率得到木糖酸二钠盐
  参考文献：
  名称：

  Bioactivity studies of oxysporone and several derivatives

  摘要：

  Recently oxysporone, a phytotoxic dihydrofuropyranone, was isolated along with two closely related compounds, afritoxinones A and B, from liquid cultures of Diplodia africana, an invasive fungal pathogen of Phoenicean juniper. In this study, eight derivatives were hemisynthesized and assayed for their phytotoxic and antifungal activities in comparison to the parent compound. Each compound was tested on non-host plants and on four destructive plant pathogens such as Athelia rolfsii, Diplodia corticola, Phytophthora cinnamomi and P. plurivora. The results on the phytotoxic activity showed that the dihydrofuropyranone carbon skeleton and both the double bond the hydroxy group of dihydropyran ring appeared to be structural features important in conferring activity. Although the data concerning the antifungal activity did not allow to extract any structure-activity relationships, it should be underlined that the conversion of oxysporone into the corresponding 4-O-benzoyl derivative led to a compound showing a good antifungal activity towards three out of the four organisms tested. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.phytol.2014.07.005

文献信息

• [EN] SYNTHESIS OF ALDONOLACTONES, ALDAROLACTONES, AND ALDARODILACTONES USING GAS SPARGING<br/>[FR] SYNTHÈSE DES ALDONOLACTONES, ALDAROLACTONES ET ALDARODILACTONES AVEC EXTRACTION PAR LE GAZ
  申请人：DU PONT

  公开号：WO2006005070A1

  公开（公告）日：2006-01-12

  Aldaric acids, aldonic acids, and their corresponding salts are cyclized to the corresponding lactone or dilactone using gas sparging to remove water.

  Aldaric酸，Aldonic酸及其相应的盐，通过气体通入的方式将水蒸发，使其环化为相应的内酯或双内酯。
• Synthesis of aldonolactones, aldarolactones, and aldarodilactones using gas sparging
  申请人：Chenault Keith Henry

  公开号：US20060084817A1

  公开（公告）日：2006-04-20

  Aldaric acids, aldonic acids, and their corresponding salts are cyclized to the corresponding lactone or dilactone using gas sparging to remove water.

  Aldaric酸，醛酸及其相应的盐通过气体冲洗去除水分，环化成相应的内酯或二内酯。
• Organic Compounds
  申请人：FAIRHURST Robin Alec

  公开号：US20090181934A1

  公开（公告）日：2009-07-16

  A composition comprising, separately or together: a component (A) that is an adenosine A 2a receptor agonist as defined in the specification; and a component (B) that is one or more compounds selected from: (i) a corticosteroid, (ii) a beta-2 adrenoceptor agonist, (iii) an antimuscarinic agent, (iv) an A 2B antagonist, (v) an antihistamine, (vi) a caspase inhibitor, (vii) an ENaC inhibitor, (viii) an LTB4 antagonist, (ix) an LTD4 antagonist, (x) a serine protease inhibitor, (xi) a PDE4 inhibitor and (xii) a dual-acting beta-2 adrenoceptor agonist/muscarinic antagonist, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructive airways disease.

  一种组合物，包括分别或共同：组分（A）是根据规范定义的腺苷A2A受体激动剂；和组分（B）是从以下一种或多种化合物中选择的：（i）皮质类固醇，（ii）β-2肾上腺素受体激动剂，（iii）抗胆碱能药物，（iv）A2B受体拮抗剂，（v）抗组胺药，（vi）半胱氨酸蛋白酶抑制剂，（vii）ENaC抑制剂，（viii）LTB4拮抗剂，（ix）LTD4拮抗剂，（x）丝氨酸蛋白酶抑制剂，（xi）PDE4抑制剂和（xii）双重作用的β-2肾上腺素受体激动剂/胆碱能拮抗剂，用于治疗炎性或阻塞性呼吸道疾病的同时、顺序或分别给药。
• Welkstoffe und Antibiotica. 13. Mitteilung. Über die Konstitution des Patulins und der Desoxypatulinsäure
  作者：B. G. Engel、W. Brzeski、Pl. A. Plattner

  DOI：10.1002/hlca.19490320548

  日期：——

  1. Es wurde die Reaktion von Patulin mit Chromsäure, mit methylalkoholischer Schwefelsäure und mit Cyanwasserstoff bzw. mit Kaliumcyanid untersucht.

  1.有人因Chromsäure破坏了Patulin的破坏，又因Cyanwasserstoff破坏了甲基的AlkoholischerSchwefelsäure和mit。MIT Kaliumcyanid untersucht。
• Compositions and methods for treating hemorrhagic virus infections and other disorders
  申请人：——

  公开号：US20030092684A1

  公开（公告）日：2003-05-15

  Methods for the treatment or prevention of disorders, including acute inflammatory disorders involving pathological responses of the immune system, such as viral hemorrhagic diseases, sepsis, rheumatoid arthritis and other autoimmune disorders, acute cardiovascular events, flare-ups and acute phases of multiple sclerosis, wasting disorders and other disorders involving deleterious expression of cytokines and other factors, are provided.

  提供了治疗或预防疾病的方法，包括涉及免疫系统病理反应的急性炎症性疾病，如病毒性出血性疾病、败血症、类风湿性关节炎和其他自身免疫性疾病、急性心血管事件、多发性硬化症发作和急性期、消耗性疾病和其他涉及细胞因子和其他因子有害表达的疾病。

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