1-乙酰基环丁烷羧酸 | 639782-98-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 中文名称: 1-乙酰基环丁烷羧酸
• 英文名称: Cyclobutanecarboxylicacid, 1-acetyl-
• 英文别名: 1-acetylcyclobutane-1-carboxylic acid
• CAS: 639782-98-2
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: UEGRELUVIIQPMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-乙酰基环丁烷羧酸 在 dirhodium tetraacetate 吡啶 、 氢氧化钾 、 三甲基氯硅烷 、 二异丁基氢化铝 、 potassium carbonate 、 三乙胺 、 氯甲酸甲酯 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯苯 为溶剂， 反应 56.5h， 生成
  参考文献：
  名称：

  Structure−Activity Relationship Studies of Illudins:  Analogues Possessing a Spiro-cyclobutane Ring

  摘要：

  Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.

  DOI：

  10.1021/jo0346499
• 作为产物：
  描述：

  1,1-环丁烷-乙二酸二乙酯 在 氢氧化钾 、 copper(l) iodide 、 氯化亚砜 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 、 水 为溶剂， 反应 69.5h， 生成 1-乙酰基环丁烷羧酸
  参考文献：
  名称：

  Structure−Activity Relationship Studies of Illudins:  Analogues Possessing a Spiro-cyclobutane Ring

  摘要：

  Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.

  DOI：

  10.1021/jo0346499

文献信息

• Antibodies and immunoconjugates
  申请人：Genentech, Inc.

  公开号：US10017577B2

  公开（公告）日：2018-07-10

  The invention provides immunoconjugates and methods of using the same.

  本发明提供了免疫结合剂及其使用方法。
• POLYCARBONATE POLYOL COMPOSITIONS AND METHODS
  申请人：Allen Scott D.

  公开号：US20110230580A1

  公开（公告）日：2011-09-22

  In one aspect, the present disclosure encompasses polymerization systems for the copolymerization of CO 2 and epoxides comprising 1) a catalyst including a metal coordination compound having a permanent ligand set and at least one ligand that is a polymerization initiator, and 2) a chain transfer agent having two or more sites that can initiate polymerization. In a second aspect, the present disclosure encompasses methods for the synthesis of polycarbonate polyols using the inventive polymerization systems. In a third aspect, the present disclosure encompasses polycarbonate polyol compositions characterized in that the polymer chains have a high percentage of —OH end groups and a high percentage of carbonate linkages. The compositions are further characterized in that they contain polymer chains having an embedded polyfunctional moiety linked to a plurality of individual polycarbonate chains.
• POLYMER COMPOSITIONS AND METHODS
  申请人：Allen Scott D.

  公开号：US20130172482A1

  公开（公告）日：2013-07-04

  The present invention encompasses polymer compositions comprising aliphatic polycarbonate chains containing sites of olefinic unsaturation. In certain embodiments the aliphatic polycarbonate chains comprise sites of olefinic unsaturation capable of participating in radical-promoted olefin polymerizations. In certain embodiments, the invention encompasses composites formed by the polymerization or cross-linking of a combination of olefinic monomers and aliphatic polycarbonate chains containing sites of olefinic unsaturation.
• ADHESIVE COMPOSITIONS AND METHODS
  申请人：NOVOMER, INC.

  公开号：US20130274401A1

  公开（公告）日：2013-10-17

  The present invention encompasses polyurethane adhesive compositions comprising aliphatic polycarbonate chains. In one aspect, the present invention encompasses polyurethane adhesives derived from aliphatic polycarbonate polyols and polyisocyanates wherein the polyol chains contain a primary repeating unit having a structure: In another aspect, the invention provides articles comprising the inventive polyurethane compositions as well as methods of making such compositions.
• ALIPHATIC POLYCARBONATE POLYOLS CONTAINING SILYL GROUPS
  申请人：Novomer, Inc.

  公开号：US20140024795A1

  公开（公告）日：2014-01-23

  In one aspect, the present invention pertains to novel silyl polyurethane (SPUR) compositions incorporating aliphatic polycarbonate polyols, as well as methods of making, formulating and using these novel materials. Also provided are films and higher polymers made from the novel SPUR compositions, as well as articles coated with, made from, or incorporating these compositions.

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