2-fluoromalonyl dichloride

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-fluoromalonyl dichloride
• 英文别名: 2-Fluoro-propanedioyl dichloride；2-fluoropropanedioyl dichloride
• 化学式: C₃HCl₂FO₂
• 分子量: 158.944
• InChiKey: AWKSTUFHEIFCEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-fluoromalonyl dichloride 、 苯硫酚 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以354 mg的产率得到S,S'-diphenyl 2-fluorodithiomalonate
  参考文献：
  名称：

  Efficient Synthesis of Dissymmetric Malonic Acid S,O-Esters via Monoalcoholysis of Symmetric Dithiomalonates under Neutral Conditions

  摘要：

  A novel method for the highly selective synthesis of dissymmetric S,O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S,O-malonates is also shown.

  DOI：

  10.1021/ol201744u
• 作为产物：
  描述：

  2-fluoromalonic acid 在 oxychloride 作用下， 反应 0.5h， 生成 2-fluoromalonyl dichloride
  参考文献：
  名称：

  Efficient Synthesis of Dissymmetric Malonic Acid S,O-Esters via Monoalcoholysis of Symmetric Dithiomalonates under Neutral Conditions

  摘要：

  A novel method for the highly selective synthesis of dissymmetric S,O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S,O-malonates is also shown.

  DOI：

  10.1021/ol201744u

文献信息

• Efficient Synthesis of Dissymmetric Malonic Acid <i>S</i>,<i>O</i>-Esters via Monoalcoholysis of Symmetric Dithiomalonates under Neutral Conditions
  作者：Kazumasa Matsuo、Mitsuru Shindo

  DOI：10.1021/ol201744u

  日期：2011.8.19

  A novel method for the highly selective synthesis of dissymmetric S,O-malonates starting from symmetric diphenyl dithiomalonates under neutral conditions is described. The key step is the thermal formation of an acylketene, the stability of which would contribute to the selectivity. The synthetic utility of the dissymmetric S,O-malonates is also shown.