4-methyl-5-(β-hydroxyethyl)thiazole phosphate | 3269-79-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methyl-5-(β-hydroxyethyl)thiazole phosphate
• 英文别名: 4-methyl-5-hydroxyethylthiazole phosphate；4-methyl-5-(2-phosphonooxyethyl)thiazole；phosphoric acid mono-[2-(4-methyl-thiazol-5-yl)-ethyl] ester；phosphoric acid mono-[2-(4-methyl-thiazol-5-yl)-ethyl ester]；Phosphorsaeure-mono-[2-(4-methyl-thiazol-5-yl)-aethylester]；4-Methyl-5-(2-hydroxy-aethyl)-thiazol-phosphorsaeureester；2-(4-methyl-1,3-thiazol-5-yl)ethyl dihydrogen phosphate
• CAS: 3269-79-2
• 化学式: C₆H₁₀NO₄PS
• 分子量: 223.189
• InChiKey: OCYMERZCMYJQQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-methyl-5-(β-hydroxyethyl)thiazole phosphate 、 4-amino-5-(hydroxymethyl)-2-methylpyrimidine pyrophosphate 在 thiamine phosphate synthase 、 potassium acetate 作用下， 反应 0.02h， 生成 phosphoric acid mono-[2-(2,7-dimethyl-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidin-8-yl)-ethyl] ester
  参考文献：
  名称：

  Hazra, Amrita; Chatterjee, Abhishek; Begley, Tadhg P., Journal of the American Chemical Society, 2009, vol. 131, p. 3225 - 3229

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基-5-(beta-羟乙基)噻唑 在 磷酸 、 phosphorus pentoxide 作用下， 反应 2.0h， 生成 4-methyl-5-(β-hydroxyethyl)thiazole phosphate
  参考文献：
  名称：

  Leichssenring,G.; Schmidt,J., Chemische Berichte, 1962, vol. 95, p. 767 - 772

  摘要：

  DOI：

文献信息

• Thiamin Phosphate Synthase:  The Rate of Pyrimidine Carbocation Formation
  作者：Jeremiah W. Hanes、Steven E. Ealick、Tadhg P. Begley

  DOI：10.1021/ja0679634

  日期：2007.4.1

  Thiamin phosphate synthase couples 4-amino-5-(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) and 4-methyl-5-(β-hydroxyethyl)thiazole phosphate (Thz-P) to make thiamin phosphate on the biosynthetic route to thiamin-PP, the active form of vitamin B1. We show that this coupling reaction goes through a pyrimidine carbocation intermediate by using transient state kinetic methods, and that the

  硫胺磷酸合酶偶联 4-氨基-5-(羟甲基)-2-甲基嘧啶焦磷酸 (HMP-PP) 和 4-甲基-5-(β-羟乙基)噻唑磷酸盐 (Thz-P)，通过生物合成途径制备磷酸硫胺硫胺素-PP，维生素B1的活性形式。我们通过使用瞬态动力学方法表明该偶联反应通过嘧啶碳正离子中间体，并且酶活性位点碳正离子形成的速率常数为 0.4 s-1。
• Method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in an essential metabolic pathway and compounds and pharmaceutical compositions useful therefor
  申请人：Pyro Pharmaceuticals, Inc.

  公开号：US20040006040A1

  公开（公告）日：2004-01-08

  A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce the penultimate or ultimate product particularly by inhibiting the activity of one or more of the enzymes in the pathway, and compounds and pharmaceutical compositions for inhibiting infections of pathogenic microorganisms by inhibiting such enzymes.

  一种通过抑制代谢途径中的一个或多个酶，抑制底物转化为产生次终产物或终产物的方法，特别是通过抑制途径中一个或多个酶的活性，用于鉴定和治疗病原微生物感染，以及用于抑制这些酶的化合物和制药组合物，用于抑制病原微生物感染。
• Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
  申请人：Ceres Incorporated

  公开号：EP1059354A2

  公开（公告）日：2000-12-13

  The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR or as a 3' termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related DNA fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait.

  本发明提供了构成植物基因组片段的 DNA 分子及其编码的多肽。这些 DNA 分子可作为启动子或蛋白质编码序列或 UTR 或 3'终止序列，用于指定细胞中的基因产物，也可用于控制染色体中基因的行为，控制基因的表达，或作为基因绘图、识别或分离相同或相关 DNA 片段、或识别特定生物个体或具有共同性状的生物群体的工具。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Screening method for identifying genes involved in plant cell cycle
  申请人：VIB VZM

  公开号：EP2527451A1

  公开（公告）日：2012-11-28

  The present invention relates to a novel method for screening proteins related to and/or involved in plant cell cycle. It further relates to proteins isolated with the method, and the use of those proteins, and/or the genes encoding those proteins for modulating plant yield and plant growth.

  本发明涉及一种筛选与植物细胞周期有关和/或参与植物细胞周期的蛋白质的新方法。本发明还涉及用该方法分离的蛋白质，以及使用这些蛋白质和/或编码这些蛋白质的基因来调节植物产量和植物生长。