苯并[g]喹啉-4-胺 | 21212-62-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 苯并[g]喹啉-4-胺
• 英文名称: benzo[g]quinolin-4-ylamine
• 英文别名: Benzo[g]chinolin-4-ylamin；4-Amino-benzochinolin；4-Aminobenzochinolin；Benzo[g]quinolin-4-amine
• CAS: 21212-62-4
• 化学式: C₁₃H₁₀N₂
• 分子量: 194.236
• InChiKey: VLHYVMQBHCFSNC-UHFFFAOYSA-N

物化性质

• 熔点：
  233 °C
• 沸点：
  437.3±20.0 °C(Predicted)
• 密度：
  1.268±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  2-methyl-benzo[g]quinolin-4-ylamine 在 吡啶 、 potassium permanganate 作用下， 生成 苯并[g]喹啉-4-胺
  参考文献：
  名称：

  Albert et al., Journal of the Chemical Society, 1948, p. 1284,1290

  摘要：

  DOI：

文献信息

• [EN] NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF<br/>[FR] COMPOSÉS DE LIAISON D'ACIDE NUCLÉIQUE, PROCÉDÉS DE FABRICATION, ET UTILISATION DE CEUX-CI
  申请人：UNIV ROCHESTER

  公开号：WO2012092367A1

  公开（公告）日：2012-07-05

  The present invention relates to oligomer compounds, including dimers and trimers, formed by a disulfide, sulfinyl thio, olefin or hydrocarbon bond, or a hydrazone exchange bond between two or more monomers. Methods of making the monomers and the oligomers is also disclosed. Use of the compounds for inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-1 RNA frameshifting stem-loop and a (CUG)n expanded repeat stem- loop are disclosed, as are methods of treating diseases associated with these target RNA molecules.

  本发明涉及由二硫化物、亚硫醚硫、烯烃或碳氢键，或两个或更多单体之间的缩醛交换键形成的寡聚物化合物，包括二聚体和三聚体。还公开了制备单体和寡聚物的方法。利用这些化合物抑制靶RNA分子的活性，特别是那些具有包括茎或茎环形成的二级结构的RNA分子的活性。公开了能够抑制HIV-1 RNA移码茎环和(CUG)n扩展重复茎环活性的二聚体化合物，以及治疗与这些靶RNA分子相关的疾病的方法。
• NUCLEIC ACID BINDING COMPOUNDS, METHODS OF MAKING, AND USE THEREOF
  申请人：Miller Benjamin L.

  公开号：US20140050778A1

  公开（公告）日：2014-02-20

  The present invention relates to oligomer compounds, including dimers and trimers, formed by a disulfide, sulfinyl thio, olefin or hydrocarbon bond, or a hydrazone exchange bond between two or more monomers. Methods of making the monomers and the oligomers is also disclosed. Use of the compounds for inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-1 RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules.

  本发明涉及由二硫键、亚磺酰基硫、烯烃或碳氢键或者两个或多个单体之间的肼交换键形成的寡聚物化合物，包括二聚体和三聚体。本发明还公开了制备单体和寡聚物的方法。该化合物用于抑制目标RNA分子的活性，特别是那些具有包括茎或茎环形成的二级结构的RNA分子。公开了能够抑制HIV-1RNA框移茎环和（CUG）n扩展重复茎环的二聚体化合物，以及治疗与这些目标RNA分子相关的疾病的方法。
• US6057287A
  申请人：——

  公开号：US6057287A

  公开（公告）日：2000-05-02
• US6274596B1
  申请人：——

  公开号：US6274596B1

  公开（公告）日：2001-08-14
• [EN] BENZOQUINOLINE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS<br/>[FR] DERIVES DE BENZOQUINOLINE UTILES COMME ANTIBACTERIENS
  申请人：SCRIPTGEN PHARM INC

  公开号：WO2000024389A2

  公开（公告）日：2000-05-04

  Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having formulas (I) to (V). In formula (I), X i selected from the group consisting of O, S, CH2, CH2-CH2, C=O or NR8; Z is C or N; R1, R2, R3, and R4 are independently selected from the group consisting of hydrogen, halogen, linear or branched chain lower alkyl, alkenyl, alkynyl, alkoxy or acyl; X-RA and R3, or R3 and R4 are optionally linked together to form a ring or a salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed are methods of inhibiting bacterial growth, comprising the administration of formulations comprising the compounds of formulas (I) to (V).