3α,20α_F-diacetoxy-5α-pregnane | 6003-18-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α,20α_F-diacetoxy-5α-pregnane
• 英文别名: 3α,20α_F-Diacetoxy-5α-pregnan；(10S)-3t-Acetoxy-10r.13c-dimethyl-17c-((S)-1-acetoxy-aethyl)-(5tH.8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；5α-Pregnandiyl-(3α.20α_F)-diacetat；(20S)-3α,20α-Diacetoxy-5α-pregnan；Allopregnane-3alpha,20alpha-diol diacetate；[(3R,5S,8R,9S,10S,13S,14S,17S)-17-[(1S)-1-acetyloxyethyl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
• CAS: 6003-18-5
• 化学式: C₂₅H₄₀O₄
• 分子量: 404.59
• InChiKey: VDZDKQBSTYNFGG-GESQZIMISA-N

物化性质

• 熔点：
  256-260 °C

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3α,20α_F-diacetoxy-5α-pregnane 在 chromium(VI) oxide 、 氢氧化钾 、 溶剂黄146 作用下， 生成 (3α,5α)-3-(acetyloxy)pregnan-20-one
  参考文献：
  名称：

  Hirschmann et al., Journal of Biological Chemistry, 1951, vol. 192, p. 115,124

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酸酐 、 alkaline earth salt of/the/ methylsulfuric acid 生成 3α,20α_F-diacetoxy-5α-pregnane
  参考文献：
  名称：

  Sterols. XLIX.^* Isolation of Pregnanediols from Bull's Urine

  摘要：

  DOI：

  10.1021/ja01279a028

文献信息

• Sterols. XLIX.^* Isolation of Pregnanediols from Bull's Urine
  作者：Russell E. Marker、Eugene L. Wittle、Elmer J. Lawson

  DOI：10.1021/ja01279a028

  日期：1938.12
• Hirschmann; Hirschmann, Journal of Biological Chemistry, 1950, vol. 184, p. 259,271
  作者：Hirschmann、Hirschmann

  DOI：——

  日期：——
• Kyle; Marrian, Biochemical Journal, 1951, vol. 49, p. 80,81
  作者：Kyle、Marrian

  DOI：——

  日期：——
• Hirschmann et al., Journal of Biological Chemistry, 1951, vol. 192, p. 115,124
  作者：Hirschmann et al.

  DOI：——

  日期：——
• Den sharing behaviour of captive brushtail possums (<i>Trichosurus vulpecula</i>)
  作者：T. D. Day、C. E. O'Connor、J. R. Waas

  DOI：10.1080/03014223.2000.9518224

  日期：2000.1

  Den sharing among wild brushtail possums (Trichosurus vulpecula) has important implications for disease transmission. This study investigated den sharing in captive possums, and measured interactions between possums sharing dens. Thirty-four sexually mature possums (16 female, 18 male) were housed in single-sex or mixed-sex pairs in large enclosures that contained two dens. Daily patterns of den sharing were recorded for each pair over a 69 day period in the breeding or nonbreeding season. Social behaviour within shared dens was sampled using miniature infrared cameras. Male pairs rarely shared dens in the breeding or nonbreeding seasons (4% and 1% of days respectively) and usually engaged in 'threats' and 'fights' associated with den defence. Pairs of female possums tin both seasons) and mixed-sex pairs housed together in the breeding season shared dens most frequently (between 84% and 91% of days), and also spent the most time together in dens each night. While sharing dens, affiliative interactions were frequent, including long periods of 'touching', and also 'food sharing' and 'allogrooming'. The preference for den sharing and close contact shown by captive possums highlights the importance of den sharing as a potential route for disease transmission.