1-(4-(but-3-en-1-yl)phenyl)ethan-1-one | 15451-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(but-3-en-1-yl)phenyl)ethan-1-one
• 英文别名: 4--buten-(1)；1-(4-But-3-enylphenyl)ethanone
• CAS: 15451-36-2
• 化学式: C₁₂H₁₄O
• 分子量: 174.243
• InChiKey: ZBVBPIRVORCLIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-(but-3-en-1-yl)phenyl)ethan-1-one 在 /BRN= 742035/ 作用下， 生成 4-(p-Cyan-phenyl)-2-trifluoracetoxy-butan
  参考文献：
  名称：

  Solvents of low nucleophilicity. XI. Modified aromatic .sigma. values in the addition of trifluoroacetic acid to phenylbutenes

  摘要：

  DOI：

  10.1021/jo01267a008
• 作为产物：
  描述：

  4-(3-丁烯-1-基)溴苯 以 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 1-(4-(but-3-en-1-yl)phenyl)ethan-1-one
  参考文献：
  名称：

  Solvents of low nucleophilicity. XI. Modified aromatic .sigma. values in the addition of trifluoroacetic acid to phenylbutenes

  摘要：

  DOI：

  10.1021/jo01267a008

文献信息

• Generation of Alkyl Radical through Direct Excitation of Boracene-Based Alkylborate
  作者：Yukiya Sato、Kei Nakamura、Yuto Sumida、Daisuke Hashizume、Takamitsu Hosoya、Hirohisa Ohmiya

  DOI：10.1021/jacs.0c04456

  日期：2020.6.3

  The generation of tertiary, secondary, and primary alkyl radicals has been achieved by the direct visible-light excita-tion of a boracene-based alkylborate. This system is based on the photophysical properties of the organoboron mole-cule. The protocol is applicable to decyanoalkylation, Giese addition, and nickel-catalyzed carbon-carbon bond for-mations such as alkyl-aryl cross-coupling or vicinal

  叔、仲和伯烷基自由基的产生是通过硼苯基烷基硼酸酯的直接可见光激发来实现的。该系统基于有机硼分子的光物理特性。该协议适用于脱氰烷基化、Giese 加成和镍催化的碳-碳键形成，例如烯烃的烷基-芳基交叉偶联或邻位烷基芳基化，从而能够将各种 C(sp3) 片段引入到有机分子。
• para-Selective, Direct C(sp²)–H Alkylation of Electron-Deficient Arenes by the Electroreduction Process
  作者：Pufan Ni、Lei Yang、Jiasheng Yang、Ruihua Cheng、Weiping Zhu、Yueyue Ma、Jinxing Ye

  DOI：10.1021/acs.joc.2c02412

  日期：2023.5.5

  para-selective C(sp2)–H alkylation of electron-deficient arenes based on the electroreduction-enabled radical addition of alkyl bromides has been developed under mild conditions. In the absence of any metals and redox agents, the simple electrolysis system tolerates a variety of primary, secondary, and tertiary alkyl bromides and behaves as an important complement to the directed alkylation of the C(sp2)–H bond

  已经在温和条件下开发了基于电还原启用的烷基溴自由基加成的缺电子芳烃的直接对位选择性 C(sp 2 )–H 烷基化。在没有任何金属和氧化还原剂的情况下，简单的电解系统可以耐受多种伯、仲和叔烷基溴化物，并且可以作为 C(sp 2 )–H 键和经典 Friedel 的定向烷基化的重要补充-Crafts 烷基化。这种电还原过程为缺电子芳烃提供了一种更直接、对环境无害且有效的烷基化方法。
• Ni-catalyzed Reductive Deaminative Arylation at sp³ Carbon Centers
  作者：Raul Martin-Montero、Veera Reddy Yatham、Hongfei Yin、Jacob Davies、Ruben Martin

  DOI：10.1021/acs.orglett.9b01016

  日期：2019.4.19

  A Ni-catalyzed reductive deaminative arylation at unactivated sp(3) carbon centers is described. This operationally simple and user-friendly protocol exhibits excellent chemoselectivity profile and broad substrate scope, thus complementing existing metal-catalyzed cross-coupling reactions to forge sp(3) C-C linkages. These virtues have been assessed in the context of late-stage functionalization, hence providing a strategic advantage to reliably generate structure diversity with amine-containing drugs.
• Process for producing epoxides
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0540009B1

  公开（公告）日：1995-08-30
• US5367087A
  申请人：——

  公开号：US5367087A

  公开（公告）日：1994-11-22