4-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenyl]-2,4-dioxo-1-butanoic acid | 82760-79-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenyl]-2,4-dioxo-1-butanoic acid
• 英文别名: 2,4-Dioxo-4-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenyl]butanoic acid
• CAS: 82760-79-0
• 化学式: C₂₀H₁₈O₄
• 分子量: 322.361
• InChiKey: LNMZEKFOSDKWOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(4-acetylphenyl)-1,2,3,4-tetrahydronaphthalene 在 sodium hydroxide 、 sodium methylate 作用下， 以 1,4-二氧六环 、 乙醇 、 苯 为溶剂， 反应 2.5h， 生成 4-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenyl]-2,4-dioxo-1-butanoic acid
  参考文献：
  名称：

  Inhibitors of glycolic acid oxidase. 4-Substituted-2,4-dioxobutanoic acid derivatives

  摘要：

  Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized. These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase. The I50 value of the two most potent representatives, 4-(4'-bromo[1,1'-biphenyl]-4-yl)-2, 4-dioxobutanoic acid (8) and 4-[4'-[[(3,4-dihydro-3-hydroxy-2H-1, 5-benzodioxepin-3-yl)methyl]thio][1,1'-biphenyl]-4-yl]-2, 4-dioxobutanoic acid (13) is 6 X 10(-8)M.

  DOI：

  10.1021/jm00362a020

文献信息

• CRAGOE, E. J.;PATCHETT, A. A.;ROOROY, C. S.;WILLIAMS, H. W. R.
  作者：CRAGOE, E. J.、PATCHETT, A. A.、ROOROY, C. S.、WILLIAMS, H. W. R.

  DOI：——

  日期：——
• US4336397A
  申请人：——

  公开号：US4336397A

  公开（公告）日：1982-06-22
• Inhibitors of glycolic acid oxidase. 4-Substituted-2,4-dioxobutanoic acid derivatives
  作者：H. W. R. Williams、E. Eichler、W. C. Randall、C. S. Rooney、E. J. Cragoe、K. B. Streeter、H. Schwam、S. R. Michelson、A. A. Patchett、D. Taub

  DOI：10.1021/jm00362a020

  日期：1983.8

  Fourteen new 4-substituted 2,4-dioxobutanoic acids have been synthesized. These compounds, all of which contain lipophilic 4-substituents, are potent inhibitors in vitro of porcine liver glycolic acid oxidase. The I50 value of the two most potent representatives, 4-(4'-bromo[1,1'-biphenyl]-4-yl)-2, 4-dioxobutanoic acid (8) and 4-[4'-[[(3,4-dihydro-3-hydroxy-2H-1, 5-benzodioxepin-3-yl)methyl]thio][1,1'-biphenyl]-4-yl]-2, 4-dioxobutanoic acid (13) is 6 X 10(-8)M.