3-cyclohexylidene-butan-2-one | 62614-92-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-cyclohexylidene-butan-2-one
• 英文别名: 3-Cyclohexyliden-butan-2-on；1-Cyclohexyliden-1-methyl-aceton；3-Cyclohexylidenebutan-2-one
• CAS: 62614-92-0
• 化学式: C₁₀H₁₆O
• 分子量: 152.236
• InChiKey: NJVNEJSBBVXLKX-UHFFFAOYSA-N

物化性质

• 沸点：
  100-105 °C(Press: 2 Torr)
• 密度：
  0.929 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  乙醇 、 3-cyclohexylidene-butan-2-one 、 sodium ethanolate 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  352. α-Methyl-trans-hexahydroindene-2-acetic acid and the reduction of Δ^α- and Δ^β-unsaturated trans-hexahydrohydrindene (2) compounds

  摘要：

  DOI：

  10.1039/jr9330001485
• 作为产物：
  描述：

  2-环己基丙酸 在 氯化亚砜 作用下， 生成 3-cyclohexylidene-butan-2-one 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  352. α-Methyl-trans-hexahydroindene-2-acetic acid and the reduction of Δ^α- and Δ^β-unsaturated trans-hexahydrohydrindene (2) compounds

  摘要：

  DOI：

  10.1039/jr9330001485

文献信息

• CATALYST FOR ASYMMETRIC HYDROGENATION AND METHOD FOR MANUFACTURING OPTICALLY ACTIVE CARBONYL COMPOUND USING THE SAME
  申请人：YAMADA Shinya

  公开号：US20120136176A1

  公开（公告）日：2012-05-31

  The present invention provides a catalyst used for manufacturing an optically active carbonyl compound by selective asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, which is insoluble in a reaction mixture, and a method for manufacturing the corresponding optically active carbonyl compound. Particularly, the invention provides a catalyst for obtaining an optically active citronellal useful as a flavor or fragrance, by selective asymmetric hydrogenation of citral, geranial or neral. The invention relates to a catalyst for asymmetric hydrogenation of an α,β-unsaturated carbonyl compound, which comprises: a powder of at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table, or a metal-supported substance in which the at least one metal is supported on a support; an optically active peptide compound; and an acid, and also relates to a method for manufacturing an optically active carbonyl compound using the same.

  本发明提供了一种用于通过选择性不对称加氢α，β-不饱和羰基化合物制备光学活性羰基化合物的催化剂，该催化剂在反应混合物中不溶解，并提供了制备相应光学活性羰基化合物的方法。特别地，该发明提供了一种催化剂，通过选择性不对称加氢柠檬醛、香叶醛或柠檬醛制备出用作香料或芳香剂的光学活性香茅醛。该发明涉及一种用于不对称加氢α，β-不饱和羰基化合物的催化剂，包括：来自周期表第8至第10族金属中至少一种金属的粉末，或者至少一种金属负载物质，其中至少一种金属负载在一种载体上；一种光学活性肽化合物；和一种酸，还涉及使用该催化剂制备光学活性羰基化合物的方法。
• Construction of polycyclic structures with vicinal all-carbon quaternary stereocenters <i>via</i> an enantioselective photoenolization/Diels–Alder reaction
  作者：Min Hou、Mengmeng Xu、Baochao Yang、Haibing He、Shuanhu Gao

  DOI：10.1039/d1sc00883h

  日期：——

  present in one molecule, they will dramatically increase its synthetic challenge. A chiral titanium promoted enantioselective photoenolization/Diels–Alder (PEDA) reaction allows largely stereohindered tetra-substituted dienophiles to interact with highly active photoenolized hydroxy-o-quinodimethanes, delivering fused or spiro polycyclic rings bearing vicinal all-carbon quaternary centers in excellent

  全碳四元立构中心在天然产物中普遍存在，并且在药物分子中具有重要意义。然而，由于化学环境拥挤，全碳立构中心的构建是一个具有挑战性的项目。而且，当一个分子中存在邻位全碳四元立构中心时，它们将极大地增加其合成挑战。手性钛促进的对映选择性光烯醇化/狄尔斯-阿尔德（PEDA）反应允许很大程度上立体受阻的四取代亲二烯体与高活性光烯醇化羟基-邻醌二甲烷相互作用，以优异的对映体过量提供带有邻位全碳四元中心的稠合或螺环多环通过一步操作。这种新开发的对映选择性 PEDA 反应将激发不对称激发态反应的其他进展，并可用于结构相关的复杂天然产物或药物分子的全合成，以进行药物发现。
• Catalyst for asymmetric hydrogenation comprising peptides and method for manufacturing optically active carbonyl compound using the same
  申请人：Takasago International Corporation

  公开号：EP2457655A2

  公开（公告）日：2012-05-30

  The present invention provides a catalyst used for manufacturing an optically active carbonyl compound by selective asymmetric hydrogenation of an α, β-unsaturated carbonyl compound, which is insoluble in a reaction mixture, and a method for manufacturing the corresponding optically active carbonyl compound. Particularly, the invention provides a catalyst for obtaining an optically active citronellal useful as a flavor or fragrance, by selective asymmetric hydrogenation of citral, geranial or neral. The invention relates to a catalyst for asymmetric hydrogenation of an α, β-unsaturated carbonyl compound, which comprises: a powder of at least one metal selected from metals belonging to Group 8 to Group 10 of the Periodic Table, or a metal-supported substance in which the at least one metal is supported on a support; an optically active peptide compound; and an acid, and also relates to a method for manufacturing an optically active carbonyl compound using the same.

  本发明提供了一种通过选择性不对称氢化不溶于反应混合物中的α，β-不饱和羰基化合物来制造光学活性羰基化合物的催化剂，以及制造相应光学活性羰基化合物的方法。特别是，本发明提供了一种催化剂，通过对柠檬醛、香叶醇或橙花醛的选择性不对称氢化，获得光学活性香茅醛，用作香精或香料。本发明涉及一种用于α，β-不饱和羰基化合物不对称氢化的催化剂，它包括：至少一种选自属于元素周期表第8组至第10组的金属的粉末，或其中至少一种金属被支撑在支撑物上的金属支撑物质；一种光学活性肽化合物；以及一种酸，还涉及一种使用该催化剂制造光学活性羰基化合物的方法。
• Behavioral Treatment of Hypertensive Heart Disease in African Americans: Rationale and Design of a Randomized Controlled Trial
  作者：Robert H. Schneider、Amparo Castillo-Richmond、Charles N. Alexander、Hector Myers、Vidya Kaushik、Cesar Aranguri、Keith Norris、Chinelo Haney、Maxwell Rainforth、Raul Calderon、Sanford Nidich

  DOI：10.1080/08964280109595775

  日期：2001.1

  African Americans experience higher morbidity, and mortality, than Whites do as a result of hypertension and associated cardiovascular disease. Chronic psychosocial stress has been considered an important contributing factor to these high rates. The authors describe the rationale and design for a planned randomized controlled trial comparing Transcendental Meditation, a stress-reduction technique, with lifestyle education in the treatment of hypertension and hypertensive heart disease in urban African Americans. They pretested 170 men and women aged 20 to 70 years over a 3-session baseline period, with posttests at 6 months. Outcomes included clinic and ambulatory blood pressure, quality, of life, left ventricular mass measured by, M-mode echocardiography, left ventricular diastolic function measured by Doppler and carotid atherosclerosis measured by fi-mode ultrasound. This trial was designed to evaluate the hypothesis that a selected stress reduction technique is effective in reducing hypertension and hypertensive heart disease in African Americans.
• Colonge; Grenet, Bulletin de la Societe Chimique de France, 1954, p. 1304,1307
  作者：Colonge、Grenet

  DOI：——

  日期：——