6-(4'-chlorophenoxy)pyridazin-3-amine | 121041-33-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(4'-chlorophenoxy)pyridazin-3-amine
• 英文别名: 6-(4-chlorophenoxy)pyridazin-3-amine
• CAS: 121041-33-6
• 化学式: C₁₀H₈ClN₃O
• 分子量: 221.646
• InChiKey: QZMLFFBNTZWJNB-UHFFFAOYSA-N

物化性质

• 熔点：
  203-207 °C
• 沸点：
  437.8±35.0 °C(Predicted)
• 密度：
  1.379±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(4'-chlorophenoxy)pyridazin-3-amine 在 磷酸 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 生成 2-benzyl-6-(4'-chlorophenoxy)-3-dimethylaminomethylimidazo<1,2-b>pyridazine
  参考文献：
  名称：

  Barlin, Gordon B.; Davies, Les P.; Ireland, Stephen J., Australian Journal of Chemistry, 1992, vol. 45, # 8, p. 1281 - 1300

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氨基-6-氯哒嗪 、 对氯苯酚 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 20.0h， 以46%的产率得到6-(4'-chlorophenoxy)pyridazin-3-amine
  参考文献：
  名称：

  Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas

  摘要：

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.

  DOI：

  10.1021/jf900882c

文献信息

• Barlin, Gordon B.; Davies, Les P.; Ngu, Maria M. L., Australian Journal of Chemistry, 1988, vol. 41, # 11, p. 1735 - 1742
  作者：Barlin, Gordon B.、Davies, Les P.、Ngu, Maria M. L.

  DOI：——

  日期：——
• BARLIN, GORDON B.;DAVIES, LES P.;NGU, MARIA M. L., AUSTRAL. J. CHEM., 41,(1988) N1, C. 1735-1742
  作者：BARLIN, GORDON B.、DAVIES, LES P.、NGU, MARIA M. L.

  DOI：——

  日期：——
• [EN] NORCANTHARIDIN DERIVATIVE COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, COMPOSITIONS CONTAINING SAID COMPOUNDS AND THE USE THEREOF<br/>[FR] COMPOSES DERIVES DE NORCANTHARIDINE, LEURS PROCEDES DE PREPARATION, LES COMPOSITIONS LES CONTENANT ET LEURS UTILISATIONS.
  申请人：ENTOMED

  公开号：WO2005037839A1

  公开（公告）日：2005-04-28

  La présente invention a pour objet de nouveaux composés dérivés de norcantharidine de formule (I) suivante: (I). L'invention concerne également leurs procédés de préparation et les compositions les contenant utilisables en thérapie humaine et animale, notamment pour la prévention ou/et le traitement des cancers et d'autres pathologies associées à une dérégulation des voies de signalisation cellulaire ainsi que des infections microbiennes.
• Barlin, Gordon B.; Davies, Les P.; Ireland, Stephen J., Australian Journal of Chemistry, 1992, vol. 45, # 8, p. 1281 - 1300
  作者：Barlin, Gordon B.、Davies, Les P.、Ireland, Stephen J.、Zhang, Jiankuo

  DOI：——

  日期：——
• Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas
  作者：Ranfeng Sun、Yonglin Zhang、Fuchun Bi、Qingmin Wang

  DOI：10.1021/jf900882c

  日期：2009.7.22

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.