Ethenyl-4-phenylamino-3-quinolinecarbonitrile 6d

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Ethenyl-4-phenylamino-3-quinolinecarbonitrile 6d
• 英文别名: 7-[(E)-2-pyridin-4-ylethenyl]-4-(3,4,5-trimethoxyanilino)quinoline-3-carbonitrile
• 化学式: C₂₆H₂₂N₄O₃
• 分子量: 438.486
• InChiKey: HGPBBNDSZXAUKO-SNAWJCMRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  33
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  89.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  7-溴-4-氯-喹啉-3-甲腈 在 palladium diacetate 、 TEA 、 三(邻甲基苯基)磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Ethenyl-4-phenylamino-3-quinolinecarbonitrile 6d
  参考文献：
  名称：

  Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor

  摘要：

  Several new ethynyl- and ethenyl-4-phenylamino-3-quinolinecarbonitriles were synthesized and tested for Src inhibition. Derivatives bearing an ethenyl or ethynyl substituent at C-6 showed decreased Src inhibitory activity. Incorporation of an ethenylpyridine N-oxide group at C-7 provided 20b, a 0.6 nM inhibitor of Src enzymatic activity with excellent cellular potency. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2005.01.004

文献信息

• Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor
  作者：Ana Carolina Barrios Sosa、Diane H. Boschelli、Biqi Wu、Yan Wang、Jennifer M. Golas

  DOI：10.1016/j.bmcl.2005.01.004

  日期：2005.3

  Several new ethynyl- and ethenyl-4-phenylamino-3-quinolinecarbonitriles were synthesized and tested for Src inhibition. Derivatives bearing an ethenyl or ethynyl substituent at C-6 showed decreased Src inhibitory activity. Incorporation of an ethenylpyridine N-oxide group at C-7 provided 20b, a 0.6 nM inhibitor of Src enzymatic activity with excellent cellular potency. (c) 2005 Published by Elsevier Ltd.