The invention relates to a method for the preparation of glycoconjugates of phosphorus amides with the general formula ##STR1## where the connection of the sugar with the phosphoric acid amide mustard residue, and the ifosfamide mustard residue, respectively, occurs preferably in the 1-position, and where R.sub.1 and R.sub.2 ; which can be the same or different, denote hydrogen, lower C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.6 haloalkyl and where as sugar there can be present mono-, di-, or polysaccharides in all existing isomeric and enantiomeric forms, wherein in a known way protected brominated sugars are conjugated with the respective phosphorus compounds, and freed of the protective residues, and to the use of said compounds as anti-tumour drugs.
该发明涉及一种制备
磷酸酰胺糖共轭物的方法,其通式为##STR1##其中糖与
磷酸酰胺芥子残基和异
磷酰胺芥子残基的连接优选发生在1-位置,其中R.sub.1和R.sub.2;可以相同也可以不同,表示氢、较低的C.sub.1-C.sub.4烷基或C.sub.1-C.sub.6卤代烷基,糖可以是
单糖、
双糖或
多糖,以所有已知的同分异构体和对映体形式存在,其中通过已知方法将保护
溴糖与相应的
磷化合物共轭,并去除保护残基,以及将所述化合物用作
抗肿瘤药物。