2-Phenyl-thiazol-5-carbonsaeure-amid | 90842-20-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-Phenyl-thiazol-5-carbonsaeure-amid
• 英文别名: 2-phenyl-thiazole-5-carboxylic acid amide；2-Phenylthiazole-5-carboxamide；2-phenyl-1,3-thiazole-5-carboxamide
• CAS: 90842-20-9
• 化学式: C₁₀H₈N₂OS
• mdl: MFCD24390979
• 分子量: 204.252
• InChiKey: HOYUHRKSMCXVCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Phenyl-thiazol-5-carbonsaeure-amid 在 硫化氢 、 三乙胺 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 生成 2-Phenyl-thiazol-5-thiocarbonsaeure-amid
  参考文献：
  名称：

  Sycheva,T.P. et al., Journal of general chemistry of the USSR, 1963, vol. 33, p. 3590 - 3592

  摘要：

  DOI：
• 作为产物：
  描述：

  2-苯基噻唑-5-羧酸 在 ammonium hydroxide 、 氯化亚砜 作用下， 生成 2-Phenyl-thiazol-5-carbonsaeure-amid
  参考文献：
  名称：

  2-Phenylthiazole-4,5-dicarboxylic Acid Derivatives

  摘要：

  DOI：

  10.1021/ja01251a045

文献信息

• [EN] N-PHENYLPYRAZOLE DERIVATIVES AS PESTICIDES<br/>[FR] DERIVES DE N-PHENYLPYRAZOLE UTILISES COMME PESTICIDES
  申请人：BAYER CROPSCIENCE SA

  公开号：WO2006000313A1

  公开（公告）日：2006-01-05

  The invention relates to bis-5-pyrazolyl derivatives of formula (I) or salts thereof: wherein the various symbols are as defined in the description, to processes for their preparation, to compositions thereof, and to their use for the control of pests (including arthropods and helminths).

  这项发明涉及到式(I)的双-5-吡唑基衍生物或其盐：其中各种符号如描述中所定义，以及它们的制备方法、组合物，以及它们用于控制害虫（包括节肢动物和蠕虫）的用途。
• SUBSTITUTED PIPERIDINES CONTAINING A HETEROARYLAMIDE OR HETEROARYLPHENYL MOIETY
  申请人：Woodhead Steven John

  公开号：US20100120798A1

  公开（公告）日：2010-05-13

  The invention provides compounds of the formula (I) having PKA and PKB kinase inhibiting compounds of the formula (I): GP 1 J T 2 J N 4 R N H (I) or salts, solvates, tautomers or N-oxides thereof, wherein (1) GP is a group GP1: HET 2a a Q G (HNCO)f 7 (R)x N * (GP1) (2) GP is a group GP2: 10 (R)r O 2a a QG (CH2)w N V H N * (GP2) wherein HET is a monocyclic or bicyclic heterocyclic group containing up to 4 heteroatom ring members; the ring V is a monocyclic or bicyclic heteroaryl group of 5 to 10 ring members; and J1, J2, R4, R7, R10, Q2a, Ga, x, w and f are as defined in the claims

  本发明提供了公式（I）的化合物，它们具有PKA和PKB激酶抑制化合物的公式（I）：GP 1 J T 2 J N 4 R N H（I）或其盐，溶剂化物，互变异构体或N-氧化物，其中（1）GP是一个GP1组：HET 2a a Q G（HNCO）f 7（R）x N *（GP1）（2）GP是一个GP2组：10（R）r O 2a a QG（CH2）w N V H N *（GP2），其中HET是一个含有最多4个杂环环成员的单环或双环杂环基团；环V是5到10个环成员的单环或双环杂芳基基团；而J1，J2，R4，R7，R10，Q2a，Ga，x，w和f如权利要求所定义。
• INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Griffioen Gerard

  公开号：US20120083475A1

  公开（公告）日：2012-04-05

  This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds.

  该发明提供了新型化合物，以及这些新型化合物用作药物，特别是用于预防或治疗神经退行性疾病，更具体地说是某些神经系统疾病，例如被统称为tau病理学的疾病，以及由细胞毒性α-突触蛋白淀积所特征的疾病。本发明还涉及使用这些新型化合物制备治疗这种神经退行性疾病的药物。本发明还涉及包括这些新型化合物的制药组合物，以及制备这些新型化合物的方法。
• Compositions and Methods for the Treatment of Metabolic and Related Disorders
  申请人：Uesugi Motonari

  公开号：US20150307501A1

  公开（公告）日：2015-10-29

  The present invention relates to the compound for treatment and/or prevention of one or more metabolic disorders utilizes an A-B-C tripartite structure, wherein A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. Also provided are methods for the treatment and/or prevention of one or more metabolic disorders, for example, obesity or diabetes, utilizing fatostatin A and/or a derivative and/or analog thereof and/or the A-B-C tripartite compounds.

  本发明涉及用于治疗和/或预防一种或多种代谢性疾病的化合物，利用A-B-C三部分结构，其中A、B和C是相同或不相同的结构，例如，但不限于，带或不带取代基的杂环、苯基或苄基环结构，并在此详细描述。还提供了利用fatostatin A和/或其衍生物和/或类似物和/或A-B-C三部分化合物治疗和/或预防一种或多种代谢性疾病（例如肥胖症或糖尿病）的方法。
• Methods and Compositions for the Treatment of Cancer and Related Hyperproliferative Disorders
  申请人：Uesugi Motonari

  公开号：US20160136164A1

  公开（公告）日：2016-05-19

  The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B—C. In the tripartite structure A, B, and C are identical or non-identical structures, for example, but not limited to, heterocyclic, phenyl or benzyl ring structures with or without substitutions and are described in detail herein. The methods may utilize particular compounds, for example, having a piperidinyl, a pyrrolinyl or pyridinyl A ring, a thiazole B ring, and a phenyl C ring which may be further substituted independently.

  本发明涉及通过给予具有一般三部分结构A-B-C的化合物的治疗有效量来治疗与细胞过度增殖相关的疾病的方法。在三部分结构A、B和C中，A、B和C可以是相同或不相同的结构，例如，但不限于，杂环、苯基或苄基环结构，带或不带取代基，并在此处详细描述。该方法可以利用特定的化合物，例如，具有哌啶基、吡咯烷基或吡啶基A环，噻唑B环和苯基C环，这些环可以进一步独立地被取代。