[(3R,4S,5R)-3,4,5,6-四羟基-2-氧代己基]磷酸二氢酯 | 2650-47-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: [(3R,4S,5R)-3,4,5,6-四羟基-2-氧代己基]磷酸二氢酯
• 英文名称: D-sorbose 1-phosphate
• 英文别名: [(3R,4S,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl] dihydrogen phosphate
• CAS: 2650-47-7
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: ZKLLSNQJRLJIGT-PYWDMBMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  [(3R,4S,5R)-3,4,5,6-四羟基-2-氧代己基]磷酸二氢酯 在 silver nitrate 、 Escherichia coli acid phosphatase 、 水 作用下， 以 水 为溶剂， 以508 mg的产率得到D-山梨糖
  参考文献：
  名称：

  酶的简便酶法合成

  摘要：

  缺乏有效的制备方法阻碍了稀有酮糖的研究。本文描述了一种方便，高效且经济高效的酮糖合成平台。该方法可从常见且廉价的起始原料中制备难以获得的酮戊糖和酮己糖，且产率高，纯度高，且无需繁琐的异构体分离步骤。

  DOI：

  10.1002/anie.201505714
• 作为产物：
  描述：

  口服葡萄糖 在 Pseudomonas Sp_. St-24 D-tagatose 3-epimerase 、 Thermotoga maritima MSB₈ L-arabinose isomerase 、 Thermotoga maritima MSB₈ L-rhamnulose kinase 、 magnesium 、 锰 、 5’-三磷酸腺苷 作用下， 生成 [(3R,4S,5R)-3,4,5,6-四羟基-2-氧代己基]磷酸二氢酯
  参考文献：
  名称：

  酶的简便酶法合成

  摘要：

  缺乏有效的制备方法阻碍了稀有酮糖的研究。本文描述了一种方便，高效且经济高效的酮糖合成平台。该方法可从常见且廉价的起始原料中制备难以获得的酮戊糖和酮己糖，且产率高，纯度高，且无需繁琐的异构体分离步骤。

  DOI：

  10.1002/anie.201505714

文献信息

• Mammalian promotors useful in yeast expression
  申请人：CETUS CORPORATION

  公开号：EP0165759A2

  公开（公告）日：1985-12-27

  Expression vectors containing coding sequences under the control of mammalian promoters are disclosed as useful in producing proteins in yeasts. Construction of such vectors, and their use in yeast transformations are described.

  本发明公开了含有哺乳动物启动子控制下的编码序列的表达载体，用于在酵母中生产蛋白质。 本发明描述了此类载体的构建及其在酵母转化中的应用。
• Novel phosphobetaine and detergent and cosmetic containing the same
  申请人：Kao Corporation

  公开号：EP0514588A2

  公开（公告）日：1992-11-25

  A novel phosphobetaine is disclosed. This compound is very excellence in that it exerts a conditioning effect of imparting a good feel to the skin or hair, is excellent in humidifying properties, is available at a low price, and thus it is highly usable in detergents, cosmetics, a bathing preparation and the like. A detergent composition, a cosmetic, and a bathing preparation each containing the phosphobetaine are also disclosed.

  本研究公开了一种新型磷脂酰基化合物。这种化合物非常出色，它具有调理作用，能给皮肤或头发带来良好的触感，具有极佳的加湿性能，而且价格低廉，因此在洗涤剂、化妆品、沐浴剂等方面具有很高的实用性。此外，还公开了一种洗涤剂组合物、一种化妆品和一种沐浴剂，它们都含有磷脂质。
• Liquid composition, ink for ink-jet, ink set for ink-jet recording, ink-jet recording method, recording unit, ink cartridge, and ink-jet recording apparatus
  申请人：CANON KABUSHIKI KAISHA

  公开号：EP1191077A1

  公开（公告）日：2002-03-27

  A liquid composition for ink-jet recording, or an ink set for ink-jet recording which produces an image having water resistance and excellent print quality, and which can reduce color bleeding that occurs in formation of color images, and furthermore, which can extend a life-span of ink-jet recording heads, as well as an ink-jet recording method, a recording unit, an ink cartridge and an ink-jet recording apparatus are provided. The liquid composition or a color ink constituting the ink set comprising a polyvalent metal salt, a material selected from the group consisting of acids including amino groups and salts thereof, and a liquid medium is used.

  本发明提供了一种用于喷墨记录的液体组合物，或一种用于喷墨记录的墨水组，该墨水组可生成具有防水性和优异打印质量的图像，并可减少在形成彩色图像时出现的渗色，此外，还可延长喷墨记录头的使用寿命，同时还提供了一种喷墨记录方法、一个记录单元、一个墨盒和一个喷墨记录装置。本发明使用了由多价金属盐、选自包括氨基在内的酸及其盐组成的组的材料和液体介质构成的液体组合物或彩色墨水。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。
• Compositions and methods for modeling saccharomyces cerevisiae metabolism
  申请人：The Regents of The University of California

  公开号：EP2463654A1

  公开（公告）日：2012-06-13

  The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive of a S. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention. The invention provides an in silica model for determining a S. cerevisiae physiological function. The model includes a data structure relating a plurality of S. cerevisiae reactants to a plurality of S. cerevisiae reactions, a constraint set for the plurality of S. cerevisiae reactions, and commands for determining a distribution of flux through the reactions that is predictive of a S. cerevisiae physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. The invention further provides methods for making an in silica S. cerevisiae model and methods for determining a S. cerevisiae physiological function using a model of the invention.

  本发明提供了一种用于确定酿酒葡萄孢菌生理功能的硅胶模型。该模型包括一个将多个酿酒葡萄孢反应物与多个酿酒葡萄孢反应相关联的数据结构、多个酿酒葡萄孢反应的约束集，以及用于确定通过反应的通量分布的指令，该通量分布可预测酿酒葡萄孢的生理功能。本发明的模型可进一步包括一个基因数据库，其中包含表征相关基因的信息。本发明进一步提供了硅胶中酿酒葡萄孢模型的制作方法和使用本发明模型确定酿酒葡萄孢生理功能的方法。本发明提供了一种用于确定酿酒葡萄孢菌生理功能的硅胶模型。该模型包括将多个酿酒葡萄孢反应物与多个酿酒葡萄孢反应相关联的数据结构、多个酿酒葡萄孢反应的约束集，以及用于确定通过反应的通量分布的指令，该通量分布可预测酿酒葡萄孢的生理功能。本发明的模型可进一步包括一个基因数据库，其中包含表征相关基因的信息。本发明进一步提供了制作硅胶葡萄孢菌模型的方法和使用本发明模型确定葡萄孢菌生理功能的方法。