1,3-二氢-1-甲基异苯并呋喃 | 38189-85-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 中文名称: 1,3-二氢-1-甲基异苯并呋喃
• 英文名称: 1,3-dihydro-1-methylisobenzofuran
• 英文别名: 1-methyl-1,3-dihydroisobenzofuran；1-methylphthalan；1-methyl-1,3-dihydro-isobenzofuran；1-Methyl-phthalan；1-methyl-1,3-dihydro-2-benzofuran
• CAS: 38189-85-4
• 化学式: C₉H₁₀O
• 分子量: 134.178
• InChiKey: CDYVODHUTJKFAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,3-二氢-1-甲基异苯并呋喃 在 氧气 作用下， 生成
  参考文献：
  名称：

  Berner, Endre, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1982, vol. 36, # 10, p. 729 - 731

  摘要：

  DOI：
• 作为产物：
  描述：

  1-甲基萘-2-醇 在 potassium permanganate 、 lithium aluminium tetrahydride 、 磷酸 、 氧气 、 sodium carbonate 、 magnesium sulfate 、 臭氧 、 三苯基膦 作用下， 以 水 、 苯 为溶剂， 生成 1,3-二氢-1-甲基异苯并呋喃
  参考文献：
  名称：

  Berner, Endre, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1982, vol. 36, # 10, p. 729 - 731

  摘要：

  DOI：

文献信息

• [EN] COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE<br/>[FR] COMPOSITIONS ET LEURS MÉTHODE D'UTILISATION POUR LE TRAITEMENT D'UNE MALADIE NEURODEGENERATIVE ET MITOCHONDRIALE
  申请人：MITOKININ INC

  公开号：WO2020206363A1

  公开（公告）日：2020-10-08

  The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及含氮杂环类似物，制备含氮类似物的方法，以及使用这些类似物治疗与PINK1激酶活性相关的疾病的方法，包括但不限于神经退行性疾病、线粒体疾病、纤维化和/或心肌病。本摘要旨在作为在特定领域进行搜索的扫描工具，并不打算限制本发明。
• Iridium(<scp>iii</scp>)-bis(imidazolinyl)phenyl catalysts for enantioselective C–H functionalization with ethyl diazoacetate
  作者：N. Mace Weldy、A. G. Schafer、C. P. Owens、C. J. Herting、A. Varela-Alvarez、S. Chen、Z. Niemeyer、D. G. Musaev、M. S. Sigman、H. M. L. Davies、S. B. Blakey

  DOI：10.1039/c6sc00190d

  日期：——

  the interplay of experimental and computational insights. The reaction is tolerant of a variety of diazoacetate precursors and is found to be heavily influenced by the steric and electronic properties of the substrate. Phthalan and dihydrofuran derivatives are functionalized in good yields and excellent enantioselectivities.

  据报道，使用基于实验和计算见解的相互作用而开发的新型 Ir( III )-双(咪唑啉基)苯基催化剂家族，仅接受受体的金属碳烯进行分子间对映选择性 C-H 官能化。该反应能够耐受多种重氮乙酸盐前体，并且发现该反应很大程度上受到底物的空间和电子性质的影响。苯并呋喃和二氢呋喃衍生物以良好的收率和优异的对映选择性进行官能化。
• [EN] 3-SUBSTITUTED PROPIONIC ACIDS AS ALPHA V INTEGRIN INHIBITORS<br/>[FR] ACIDES PROPIONIQUES À SUBSTITUTION EN POSITION 3 EN TANT QU'INHIBITEURS D'INTÉGRINE ALPHA V
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2018089353A1

  公开（公告）日：2018-05-17

  The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds are antagonists to αν- containing integrins. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with dysregulation of ay- containing integrins, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

  本发明提供了化合物的公式(I)：或其立体异构体、互变异构体或药学上可接受的盐或溶剂，其中所有变量如本文所定义。这些化合物是αν-含有整合素的拮抗剂。本发明还涉及包含这些化合物的药物组合物和使用这些化合物和药物组合物来治疗与ay-含有整合素失调相关的疾病、疾病或症状的方法，例如病理纤维化、移植排斥、癌症、骨质疏松症和炎症性疾病。
• FLUOROBORON COMPOUND HAVING AROMATIC RING OR SALT THEREOF, AND METHOD FOR PRODUCING COMPOUND HAVING CYCLIC ETHER-FUSED AROMATIC RING USING THE SAME
  申请人：Tanaka Keigo

  公开号：US20100056788A1

  公开（公告）日：2010-03-04

  Provided is a fluoroboron compound which is highly safe and stable and is capable of forming a cyclic ether-fused ring by the intramolecular alkoxymethylation reaction, or a salt thereof. The compound can be synthesized by the intramolecular alkoxymethylation reaction of a fluoroboron compound represented by the formula (I) or a salt thereof in the presence of a metal catalyst. (wherein the moiety represented by the formula represents an aromatic ring; L represents a substituent such as a halogen atom; R represents a substituted or unsubstituted alkylene group having 1 or 2 carbon atoms; and M represents an alkali metal cation or the like, with the proviso that L and —R—OCH 2 BF 3 M are respectively located on contiguous carbon atoms on the aromatic ring, or in the case of a fused aromatic ring, on two carbon atoms adjacent to one carbon at the fused position).

  提供的是一种高度安全和稳定的氟硼化合物，能够通过分子内烷氧甲基化反应形成环状醚融合环，或其盐。该化合物可以在金属催化剂存在下，通过公式（I）表示的氟硼化合物或其盐的分子内烷氧甲基化反应合成。（其中由公式表示的基团代表芳香环；L代表取代基，如卤素原子；R代表取代或未取代的1或2个碳原子的烷基；M代表碱金属阳离子等，条件是L和-R-OCH2BF3M分别位于相邻的芳香环碳原子上，或在融合芳香环的情况下，在相邻的两个碳原子上，且其中一个碳原子在融合位置上）。
• Fluoroboron compound having aromatic ring or salt thereof, and method for producing compound having cyclic ether-fused aromatic ring using the same
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US08273885B2

  公开（公告）日：2012-09-25

  Provided is a fluoroboron compound which is highly safe and stable and is capable of forming a cyclic ether-fused ring by the intramolecular alkoxymethylation reaction, or a salt thereof. The compound can be synthesized by the intramolecular alkoxymethylation reaction of a fluoroboron compound represented by the formula (I) or a salt thereof in the presence of a metal catalyst. (wherein the moiety represented by the formula represents an aromatic ring; L represents a substituent such as a halogen atom; R represents a substituted or unsubstituted alkylene group having 1 or 2 carbon atoms; and M represents an alkali metal cation or the like, with the proviso that L and —R—OCH2BF3M are respectively located on contiguous carbon atoms on the aromatic ring, or in the case of a fused aromatic ring, on two carbon atoms adjacent to one carbon at the fused position).

  提供了一种高度安全稳定的氟硼化合物，能够通过分子内烷氧甲基化反应形成环状醚融合环，或其盐。该化合物可以在金属催化剂存在下，通过式(I)或其盐所代表的氟硼化合物的分子内烷氧甲基化反应合成。（其中，由式所代表的基团表示芳香环；L表示卤素原子等取代基；R表示具有1或2个碳原子的取代或未取代的烷基；M表示碱金属阳离子等，但须满足L和—R—OCH2BF3M分别位于芳香环上相邻的碳原子上，或者在融合芳香环的情况下，在相邻的两个碳原子上位于一个碳原子上）。