2-溴-2-(4-氯苯氧基)-1-苯基乙酮 | 55476-93-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-溴-2-(4-氯苯氧基)-1-苯基乙酮
• 英文名称: 2-bromo-2-(4-chlorophenoxy)-1-phenylethanone
• 英文别名: α-bromo-4-chlorophenoxy acetophenone；<4-Chlor-phenyl>-<μ-brom-phenacyl>-ether；2-Bromo-2-(4-chlorophenoxy)-1-phenylethan-1-one
• CAS: 55476-93-2
• 化学式: C₁₄H₁₀BrClO₂
• 分子量: 325.589
• InChiKey: CCSKFSDHUPMREP-UHFFFAOYSA-N

物化性质

• 熔点：
  118-119 °C
• 沸点：
  417.7±40.0 °C(Predicted)
• 密度：
  1.515±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-溴-2-(4-氯苯氧基)-1-苯基乙酮 在 吡啶 、 溴 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Chande, Madhukar S.; Joshi, Vishvas R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1995, vol. 34, # 2, p. 147 - 150

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-氯苯氧基)-1-苯基乙酮 在 溴 作用下， 以 氯仿 为溶剂， 以85%的产率得到2-溴-2-(4-氯苯氧基)-1-苯基乙酮
  参考文献：
  名称：

  Chande; Karnik; Inamdar, Journal of the Indian Chemical Society, 1990, vol. 67, # 3, p. 220 - 222

  摘要：

  DOI：

文献信息

• 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as
  申请人：Ortho Pharmaceutical Corporation

  公开号：US04791117A1

  公开（公告）日：1988-12-13

  Novel 2- or 3- aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory agents.

  描述了新型2-或3-芳基取代的咪唑[1,2-a]吡啶类化合物及其合成方法。这些化合物具有局部麻醉性能，并可用作局部麻醉剂、钙通道阻断剂和抗分泌剂。
• 1,3-heterocyclic-substituted alkane
  申请人：Imperial Chemical Industries PLC

  公开号：US04957934A1

  公开（公告）日：1990-09-18

  A 2-propanol derivative of the formula I, wherein R.sup.1 and R.sup.5, which may be the same or different, are each a triazolyl, imidazolyl, pyridyl or pyrimidinyl radical; R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, are each a hydrogen atom, a 1-6C alkyl, halogenoalkyl or alkoxy radical, a 3-8C cycloalkyl radical, or a phenyl, naphthyl, phenoxy, naphthyloxy or phenyl (1-6C alkyl) radical, in each of which the aryl group optionally bears one or more substituents selected from halogen atoms, amino, carboxamido, cyano and nitro radicals, 1-6C alkyl, halogenoalkyl, alkoxy, halogenoalkoxy and alkylamino radicals, 3-8C cycloalkyl radicals, di(1-6C alkyl)amino radicals and 2-6C alkoxycarbonyl radicals; R.sup.6 is a phenyl or naphthyl radical optionally bearing one or more substituents as defined above; X is a direct bond, an alkylene, alkenylene or alkynylene radical, or an oxyalkylene or thioalkylene radical wherein respectively the oxygen or sulphur atom is bonded to R.sup.6 or a phenylalkylene radical in which the phenyl group bears one or more substituents as defined above for R.sup.6 ; and Y is a hydrogen or halogen atom, a hydroxy, cyano or carbamoyl radical, or a phenyl(1-6C alkoxy) radical in which the phenyl group bears one or more substituents as defined above for R.sup.6 ; provided that, when Y is a cyano or carbamoyl radical, neither R.sup.2, R.sup.3 nor R.sup.4 may be an alkoxy or aryloxy radical, and either R.sup.2 is a hydrogen atom, or R.sup.3 and R.sup.4 are both hydrogen atoms; and provided that, when R.sup.1 and R.sup.5 are each a 1,2,4-triazol-1-yl radical, R.sup.2 is hydrogen and Y is a hydroxy radical, R.sup.3 and R.sup.4 may not be hydrogen or methyl when X is a direct bond, and R.sup.3 and R.sup.4 may not be hydrogen when X is a methylene radical; and for those compounds which contain a basic nitrogen atom, the pharmaceutically acceptable acid additon salts thereof.

  公式I的2-丙醇衍生物，其中R.sup.1和R.sup.5可以相同也可以不同，分别为三唑基，咪唑基，吡啶基或嘧啶基基团；R.sup.2，R.sup.3和R.sup.4可以相同也可以不同，分别为氢原子，1-6C烷基，卤代烷基或烷氧基，3-8C环烷基或苯基，萘基，苯氧基，萘氧基或苯基(1-6C烷基)基团，其中芳基基团可以选自卤素原子，氨基，羧酰胺基，氰基和硝基基团，1-6C烷基，卤代烷基，烷氧基，卤代烷氧基和烷基氨基基团，3-8C环烷基，二(1-6C烷基)胺基团和2-6C烷氧羰基基团中的一种或多种取代基；R.sup.6是苯基或萘基基团，可以选自上述定义的一个或多个取代基；X是直接键，烷基，烯基或炔基基团，或氧代烷基或硫代烷基基团，其中氧或硫原子分别与R.sup.6或苯基烷基基团中的苯基分别键合，该苯基烷基基团可以选自上述定义的一个或多个取代基；Y是氢或卤素原子，羟基，氰基或氨基甲酰基基团，或苯基(1-6C烷氧基)基团，其中苯基可以选自上述定义的一个或多个取代基；但当Y是氰基或氨基甲酰基基团时，R.sup.2，R.sup.3或R.sup.4中没有一个可以是烷氧基或芳氧基，且要么R.sup.2是氢原子，要么R.sup.3和R.sup.4都是氢原子；并且当R.sup.1和R.sup.5分别为1,2,4-三唑基基团时，R.sup.2是氢原子且Y是羟基基团，当X是直接键时，R.sup.3和R.sup.4不能同时为氢原子或甲基，当X是亚甲基基团时，R.sup.3和R.sup.4不能同时为氢原子；对于那些含有碱性氮原子的化合物，其药学上可接受的酸加成盐。
• 2- or 3- Aryl substituted imidazo [1,2-a] pyridines
  申请人：ORTHO PHARMACEUTICAL CORPORATION

  公开号：EP0261912A2

  公开（公告）日：1988-03-30

  Novel 2- or 3- aryl substituted imidazo[1,2-a]pyridines and their synthesis are described. The compounds have local anesthetic properties and are useful as local anesthetic agents, calcium channel blocking agents and antisecretory acents.

  介绍了新型 2-或 3-芳基取代咪唑并[1,2-a]吡啶及其合成方法，这些化合物具有局部麻醉特性，可用作局部麻醉剂、钙通道阻滞剂和抗分泌剂。
• Heterocyclic Compounds
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0299684A1

  公开（公告）日：1989-01-18

  A 2-propanol derivative of the formula I, wherein R' and R5, which may be the same or different, are each a triazolyl, imidazolyl, pyridyl or pyrimidinyl radical; R2, R3 and R4, which may be the same or different, are each a hydrogen atom, a 1-6C alkyl, halogenoalkyl or alkoxy radical, a 3-8C cycloalkyl radical, or a phenyl, naphthyl, phenoxy, naphthyloxy or phenyl(1-6C alkyl) radical, in each of which the aryl group optionally bears one or more substituents selected from halogen atoms, amino, carboxamido, cyano and nitro radicals, 1-6C alkyl, halogenoalkyl, alkoxy, halogenoalkoxy and alkylamino radicals, 3-8C cycloalkyl radicals, di(1-6C alkyl)amino radicals and 2-6C alkoxycarbonyl radicals; R6 is a phenyl or naphthyl radical optionally bearing one or more substituents as defined above; X is a direct bond, an alkylene, alkenylene or alkynylene radical, or an oxyalkylene or thioalkylene radical wherein respectively the oxygen or sulphur atom is bonded to R6 or a phenylalkenylene radical in which the phenyl group bears one or more substituents as defined above for R6; and Y is a hydrogen or halogen atom, a hydroxy, cyano or carbamoyl radical, or a phenyl(1-6C alkoxy) radical in which the phenyl group bears one or more substituents as defined above for R6; provided that, when Y is a cyano or carbamoyl radical, neither R2, R3 nor R4 may be an alkoxy or aryloxy radical, and either R2 is a hydrogen atom, or R3 and R4 are both hydrogen atoms; and provided that, when R' and R5 are each a 1,2,4-triazol-1-yl radical, R2 is , hydrogen and Y is a hydroxy radical, R3 arid R4 may not be hydrogen or methyl when X is a direct bond, and R3 and R4- may not be hydrogen when X is a methylene radical; and for those compounds which contain a basic nitrogen atom, the pharmaceutically acceptable acid addition salts thereof.

  式 I 的 2-丙醇衍生物，其中 R'和 R5（可以相同或不同）各自是三唑基、咪唑基、吡啶基或嘧啶基；R2、R3 和 R4（可以相同或不同）各自是氢原子、1-6C 烷基、卤代烷基或烷氧基、3-8C 环烷基或苯基、萘基、苯氧基、萘氧基或苯基（1-6C 烷基）基、其中每个芳基任选带有一个或多个选自卤素原子、氨基、羧基、氰基和硝基、1-6C 烷基、卤代烷基、烷氧基、卤代烷氧基和烷基氨基、3-8C 环烷基、二（1-6C 烷基）氨基和 2-6C 烷氧基羰基的取代基；R6 是苯基或萘基，可选择带有一个或多个如上定义的取代基；X 是直接键、亚烷基、亚烯基或亚炔基，或氧亚烷基或硫代亚烷基，其中氧原子或硫原子分别与 R6 或苯基亚烯基键合，其中苯基带有一个或多个如上文对 R6 所定义的取代基；以及 Y 是氢原子或卤素原子、羟基、氰基或氨基甲酰基，或苯基（1-6C 烷氧基）基，其中苯基带有一个或多个如上文对 R6 所定义的取代基；但当 Y 为氰基或氨基甲酰基时，R2、R3 或 R4 均不得为烷氧基或芳氧基基，且 R2 为氢原子，或 R3 和 R4 均为氢原子；当 R'和 R5 各为 1,2,4-三唑-1-基时，R2 为氢原子，Y 为羟基，当 X 为直接键时，R3 和 R4 不得为氢原子或甲基，当 X 为亚甲基时，R3 和 R4- 不得为氢原子。
• Chande; Karnik; Inamdar, Journal of the Indian Chemical Society, 1990, vol. 67, # 3, p. 220 - 222
  作者：Chande、Karnik、Inamdar、Ganguly

  DOI：——

  日期：——