4-[(6-methylpyrazin-2-yl)oxy]benzohydrazide | 1312761-54-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[(6-methylpyrazin-2-yl)oxy]benzohydrazide
• 英文别名: 4-(6-Methylpyrazin-2-yl)oxybenzohydrazide
• CAS: 1312761-54-8
• 化学式: C₁₂H₁₂N₄O₂
• 分子量: 244.253
• InChiKey: YGWBLVMSRYCROY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  90.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  吲哚-3-乙醛酰氯 、 4-[(6-methylpyrazin-2-yl)oxy]benzohydrazide 在 三乙胺 作用下， 以 甲基叔丁基醚 为溶剂， 反应 3.25h， 以8%的产率得到2-(1H-indol-3-yl)-N'7k-{4-[(6-methylpyrazin-2-yl)oxy]benzoyl}-2-oxoacetohydrazide
  参考文献：
  名称：

  Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

  摘要：

  The N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. One of the most potent kinase inhibitors of the series produced a selective growth inhibition in a panel of cultivated cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.065
• 作为产物：
  描述：

  4-[(6-甲基-2-吡嗪基)氧基]-苯甲酸乙酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 32.0h， 生成 4-[(6-methylpyrazin-2-yl)oxy]benzohydrazide
  参考文献：
  名称：

  Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

  摘要：

  The N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. One of the most potent kinase inhibitors of the series produced a selective growth inhibition in a panel of cultivated cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.03.065

文献信息

• Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure
  作者：Stefanie Schmidt、Lutz Preu、Thomas Lemcke、Frank Totzke、Christoph Schächtele、Michael H.G. Kubbutat、Conrad Kunick

  DOI：10.1016/j.ejmech.2011.03.065

  日期：2011.7

  The N'-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide motif was identified as a novel scaffold for the development of kinase inhibitors. Derivatives with a biphenyl element attached to the hydrazide structure proved to be submicromolar dual inhibitors of the cancer-related kinases IGF-1R and SRC. One of the most potent kinase inhibitors of the series produced a selective growth inhibition in a panel of cultivated cancer cell lines. (C) 2011 Elsevier Masson SAS. All rights reserved.