3-methyl-heptane-2,6-dione | 42320-01-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-methyl-heptane-2,6-dione
• 英文别名: 3-Methyl-heptan-2,6-dion；3-Methylhepta-2,6-dione；3-methylheptane-2,6-dione
• CAS: 42320-01-4
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: YLOUWNWIFUFLQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methyl-heptane-2,6-dione 在 sodium hydroxide 作用下， 生成 3,6-dimethylcyclohex-2-enone
  参考文献：
  名称：

  Kochetkov,N.K.; Gottikh,B.P., Journal of general chemistry of the USSR, 1960, vol. 30, p. 963 - 968

  摘要：

  DOI：
• 作为产物：
  描述：

  3-亚甲基-2,6-庚烷二酮 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以540 mg的产率得到3-methyl-heptane-2,6-dione
  参考文献：
  名称：

  Cyclization of 2,6-Diones over H-ZSM-5: One-pot Synthesisof Dimethylphenols and Substituted a,β-UnsaturatedCyclohexenones†

  摘要：

  用沸石 H-ZSM-5 处理 2,6-二iones，可产生二甲基苯酚 (DMP) 或 δ,δ-不饱和环己烯酮。

  DOI：

  10.1039/a604851j

文献信息

• Bifunctionalized polysaccharides
  申请人：Soula Gerard

  公开号：US20080014250A1

  公开（公告）日：2008-01-17

  The present invention relates to a dextran and/or dextran derivative bifunctionalized by at least one imidazolyl radical Im and at least one hydrophobic group Hy, the said radical and the said group being each identical and/or different and grafted or bonded to the dextran and/or dextran derivative via one or more connecting arms R, Ri or Rh and functional groups F, Fi or Fh and the pharmaceutical compositions comprising one of the said dextrans and at least one active principle.

  本发明涉及一种由至少一个咪唑基团Im和至少一个疏水基团Hy双官能化的葡聚糖和/或葡聚糖衍生物，所述基团和所述基团各自相同和/或不同，并通过一个或多个连接臂R、Ri或Rh和功能基团F、Fi或Fh嫁接或结合到葡聚糖和/或葡聚糖衍生物上，并且所述药物组合物包括所述葡聚糖之一和至少一个活性成分。
• [EN] METHODS OF MAKING AND USING NANOSTRUCTURES<br/>[FR] PROCÉDÉS DE FABRICATION ET D'UTILISATION DE NANOSTRUCTURES
  申请人：UNIV MINNESOTA

  公开号：WO2013109939A1

  公开（公告）日：2013-07-25

  The invention provides methods for attaching drugs, dyes or radiolabels to bis-MTX. This method can be used to prepare bis-MTX analogs that can be used to deliver agents, such as nanoparticles, drugs, dyes or radiolabels, to cells.

  这项发明提供了将药物、染料或放射性标记物附着到双甲氨蝶呤（bis-MTX）的方法。这种方法可用于制备可用于将纳米颗粒、药物、染料或放射性标记物传递给细胞的双甲氨蝶呤类似物。
• HIGH PENETRATION PRODRUG COMPOSITIONS OF PEPTIDES AND PEPTIDE-RELATED COMPOUNDS
  申请人：Yu Chongxi

  公开号：US20090311184A1

  公开（公告）日：2009-12-17

  The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of peptides and peptide-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of being converted to parent active drugs or drug metabolites after crossing the biological barrier and thus can render treatments for the conditions that the parent drugs or metabolites can. Additionally, the HPPs are capable of reaching areas that parent drugs may not be able to access or to render a sufficient concentration at the target areas and therefore render novel treatments. The HPPs can be administered to a subject through various administration routes, e.g., locally delivered to an action site of a condition with a high concentration or systematically administered to a biological subject and enter the general circulation with a faster rate.

  本发明提供了新型高渗透性肽和肽相关化合物的组合物，即高渗透性前药（HPP）或高渗透性前药（HPP），能够以高渗透效率穿越生物屏障。 HPP能够在穿越生物屏障后转化为父活性药物或药物代谢物，从而可以治疗父药物或代谢物可以治疗的疾病。此外，HPP能够到达父药物可能无法访问或在目标区域提供足够浓度的区域，从而提供新的治疗方法。 HPP可以通过各种给药途径给予受试者，例如在高浓度下局部给药于病情的作用部位，或系统地给予生物学受体并以更快的速率进入循环系统。
• In vivo incorporation of unnatural amino acids
  申请人：Schultz Peter

  公开号：US20070117184A1

  公开（公告）日：2007-05-24

  The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.

  本发明提供了体内合成非天然氨基酸的方法和组合物。还提供了包括非天然氨基酸蛋白质的组合物。
• Aminated complex-type sugar chain derivatives and process for the production thereof
  申请人：Kajihara Yasuhiro

  公开号：US20070060543A1

  公开（公告）日：2007-03-15

  An aminated complex-type oligosaccharide derivative, for example, of the formula (1) wherein R 1 is H—(CO)—CH 2 X, —NH—(CO)—(CH 2 ) b —CH 2 X, isothiocyanate group, —NH—(CO) a —(CH 2 ) b —CO 2 H or —NH—(CO) a —(CH 2 ) b —CHO, X being a halogen atom, a being 0 or 1, b being an integer of 1 to 4, R 2 and R 3 are a hydrogen atom or a group of the formulae (2) to (5) and may be the same or different, except for the case where both R 2 and R 3 are hydrogen or the formula (5), and the case where one of R 2 and R 3 is a hydrogen atom, with the formula (5) serving as the other thereof.

  一种动态复合型寡糖衍生物，例如，公式（1）中的衍生物，其中R1为H—（CO）—CH2X，—NH—（CO）—（CH2）b—CH2X，异硫氰酸酯基，—NH—（CO）a—（CH2）b—CO2H或—NH—（CO）a—（CH2）b—CHO，其中X为卤素原子，a为0或1，b为1至4的整数，R2和R3为氢原子或公式（2）至（5）的基团，除非R2和R3均为氢或公式（5）的情况，或者其中一个为氢原子，公式（5）作为另一个的基团。