((2R,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl hydrogen sulfate | 32810-44-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: ((2R,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl hydrogen sulfate
• 英文别名: O^5'-sulfo-guanosine；((2R,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydropurin-9-yl)-3,4-dihydroxytetrahydro-furan-2-yl)methyl hydrogen sulfate；guanosine-5'-monosulfate；Guanosin-5'-sulfat；[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen sulfate
• CAS: 32810-44-9
• 化学式: C₁₀H₁₃N₅O₈S
• 分子量: 363.308
• InChiKey: NAAAVEJZEVEAMU-UUOKFMHZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  207
• 氢给体数：
  5
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  2',3'-O-异丙亚基鸟苷 在 三氧化硫 N,N-二甲基甲酰胺络合物 、 水 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.25h， 生成 ((2R,3R,4S,5R)-5-(2-amino-6-oxo-1,6-dihydropurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl hydrogen sulfate
  参考文献：
  名称：

  WO2006/130161

  摘要：

  公开号：

文献信息

• Therapeutic Compounds Derived from Spider Venom and Their Method of Use
  申请人：Meinwald Jerrold

  公开号：US20080193452A1

  公开（公告）日：2008-08-14

  The present invention is directed to new therapeutic compounds isolated from spider venom and methods of using these new compounds. The compounds are sulfated nucleoside derivatives including ribonucleoside mono- and disulfates derived from guanine, adenosine, and cytidine. Some of these compounds are glycosylated or fucosylated bearing one or more sugar residues.

  本发明涉及从蜘蛛毒液中分离出的新的治疗化合物及使用这些新化合物的方法。这些化合物是硫酸化的核苷酸衍生物，包括从鸟嘌呤、腺嘌呤和胞嘧啶中衍生出的核苷酸单硫酸酯和双硫酸酯。其中一些化合物被糖基化或富糖基化，带有一个或多个糖残基。
• An IMMUNOLOGICAL PROCESS FOR INCREASING THE HDL CHOLESTROL CONCENTRATION
  申请人：——

  公开号：US20030026808A1

  公开（公告）日：2003-02-06

  A process for increasing the concentration of HDL cholesterol in the blood of a mammal whose blood contains cholesterol ester transfer protein (CETP) is contemplated. That process comprises the steps of: (a) immunizing the mammal with an inoculum containing a CETP immunogen that is an immunogenic polypeptide having a CETP amino acid residue sequence that is covalently bonded to an exogenous antigenic carrier polypeptide and is dissolved or dispersed in a vehicle; and (b) maintaining the immunized mammal for a time period sufficient for said immunogenic polypeptide to induce the production of antibodies that bind to CETP and lessen the transfer of cholesteryl esters from HDL. Immunogens, inocula and DNA segments useful for carrying out the invention are also disclosed.

  考虑采用一种工艺来提高血液中含有胆固醇酯转移蛋白（CETP）的哺乳动物血液中高密度脂蛋白胆固醇的浓度。该工艺包括以下步骤(a) 用含有 CETP 免疫原的接种体对哺乳动物进行免疫，CETP 免疫原是具有 CETP 氨基酸残基序列的免疫原多肽，与外源抗原载体多肽共价结合，并溶解或分散在载体中；(b) 将免疫哺乳动物维持足够长的时间，使所述免疫原多肽诱导产生与 CETP 结合的抗体，减少胆固醇酯从 HDL 的转移。还公开了用于实施本发明的免疫原、接种体和 DNA 片段。
• IMMUNOLOGICAL PROCESS FOR INCREASING THE HDL CHOLESTROL CONCENTRATION
  申请人：——

  公开号：US20030021804A1

  公开（公告）日：2003-01-30

  A process for increasing the concentration of HDL cholesterol in the blood of a mammal whose blood contains cholesterol ester transfer protein (CETP) is contemplated. That process comprises the steps of: (a) immunizing the mammal with an inoculum containing a CETP immunogen that is an immunogenic polypeptide having a CETP amino acid residue sequence and is dissolved or dispersed in a vehicle; and (b) maintaining the immunized mammal for a time period sufficient for said immunogenic polypeptide to induce the production of antibodies that bind to CETP and lessen the transfer of cholesteryl esters from HDL. Immunogens, inocula and DNA segments useful for carrying out the invention are also disclosed.

  考虑采用一种工艺来提高血液中含有胆固醇酯转移蛋白（CETP）的哺乳动物血液中高密度脂蛋白胆固醇的浓度。该工艺包括以下步骤(a) 用含有 CETP 免疫原的接种体对哺乳动物进行免疫，CETP 免疫原是具有 CETP 氨基酸残基序列的免疫原多肽，溶解或分散在载体中；以及 (b) 将免疫哺乳动物维持足够长的时间，使所述免疫原多肽诱导产生与 CETP 结合的抗体，减少胆固醇酯从高密度脂蛋白的转移。还公开了用于实施本发明的免疫原、接种体和 DNA 片段。
• US4242505A
  申请人：——

  公开号：US4242505A

  公开（公告）日：1980-12-30
• US8173797B2
  申请人：——

  公开号：US8173797B2

  公开（公告）日：2012-05-08