Z-4-OMe | 87219-44-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-4-OMe
• 英文别名: N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine methyl ester；Z-[Lys(Boc)]4-OMe
• CAS: 87219-44-1
• 化学式: C₅₃H₉₀N₈O₁₅
• 分子量: 1079.34
• InChiKey: SGBRCAGDUOPPIR-YKKXUYLKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.69
• 重原子数：
  76.0
• 可旋转键数：
  30.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  305.25
• 氢给体数：
  8.0
• 氢受体数：
  15.0

反应信息

• 作为反应物：
  描述：

  Z-4-OMe 在 lithium hydroxide monohydrate 作用下， 以 甲醇 、 水 为溶剂， 反应 2.0h， 以99%的产率得到N-alpha-carbobenzoxy-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysyl-N-epsilon-t-butyloxycarbonyl-L-lysine
  参考文献：
  名称：

  Chloride-Assisted Peptide Macrocyclization

  摘要：

  The role of the Cl- anion as a templating agent for the synthesis of cyclopeptides was assessed through the preparation of three new homocyclolysines and other six cyclic peptides by head-to-tail lactamization. Isolated yields of products obtained by chloride-templating approach were considerably higher than those gained by a cation-promoted procedure, whereby, in some cases, only the anion-assisted synthesis yielded the desired cyclopeptides.

  DOI：

  10.1021/acs.orglett.0c00036
• 作为产物：
  描述：

  N-Boc-L-赖氨酸甲酯盐酸盐 在 palladium 10% on activated carbon 、 氢气 、 1-羟基苯并三唑 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 76.99h， 生成 Z-4-OMe
  参考文献：
  名称：

  Chloride-Assisted Peptide Macrocyclization

  摘要：

  The role of the Cl- anion as a templating agent for the synthesis of cyclopeptides was assessed through the preparation of three new homocyclolysines and other six cyclic peptides by head-to-tail lactamization. Isolated yields of products obtained by chloride-templating approach were considerably higher than those gained by a cation-promoted procedure, whereby, in some cases, only the anion-assisted synthesis yielded the desired cyclopeptides.

  DOI：

  10.1021/acs.orglett.0c00036