2,2'-o-phenylene-bis-ethylamine | 42988-81-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-o-phenylene-bis-ethylamine
• 英文别名: 1,2-bis-(2-amino-ethyl)-benzene；1,2-Bis-(2-amino-aethyl)-benzol；1,2-Bis-<2-amino-aethyl>-benzol；1.2-Bis(β-aminoaethyl)benzol；1,2-Benzenediethanamine；2-[2-(2-aminoethyl)phenyl]ethanamine
• CAS: 42988-81-8
• 化学式: C₁₀H₁₆N₂
• mdl: MFCD06212560
• 分子量: 164.25
• InChiKey: VYZPXGMSAOCYOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2'-o-phenylene-bis-ethylamine 在 吡啶 、 磺酰胺 作用下， 生成 1,2,3,5,6,7-hexahydro-benzo[e][1,2,9]thiadiazonine 4,4-dioxide
  参考文献：
  名称：

  1,2,4,5-Tetrahydro-3,2,4-benzothiadiazepin-3,3-dioxide und 1,2,3,5,6,7-Hexahydro-4,3,5-benzothiadiazonin-4,4-dioxide

  摘要：

  DOI：

  10.1007/bf00911294
• 作为产物：
  描述：

  1,2-苯二乙腈 在 镍 氨 、 氢气 作用下， 生成 2,2'-o-phenylene-bis-ethylamine
  参考文献：
  名称：

  1,2,4,5-Tetrahydro-3,2,4-benzothiadiazepin-3,3-dioxide und 1,2,3,5,6,7-Hexahydro-4,3,5-benzothiadiazonin-4,4-dioxide

  摘要：

  DOI：

  10.1007/bf00911294
• 作为试剂：
  描述：

  4-(pyridin-3-yl)azetidin-2-one 、 sodium;hydride 、 、 氯化铵 、 四氢呋喃 在 氩 、 氯仿 、 magnesium sulfate 、 residue 、 silica gel 、 2,2'-o-phenylene-bis-ethylamine 、 pure product 作用下， 反应 2.17h， 生成 1-methyl-4-(pyridin-3-yl)azetidin-2-one
  参考文献：
  名称：

  NICOTINE COMPOUNDS AND ANALOGS THEREOF, SYNTHETIC METHODS OF MAKING COMPOUNDS, AND METHODS OF USE

  摘要：

  本公开的实施例提供了化合物，例如图1.1所示的化合物A、B、C和D，2'取代尼古丁化合物，氮杂环化合物，以太键结合的尼古丁化合物（图1.2，化合物E、F、G和H），化合物的合成方法，使用化合物A、B、C、D、2'取代尼古丁化合物、氮杂环化合物或以太键结合的尼古丁化合物治疗疾病的方法，选择性刺激α7 nAChR和/或α4beta2受体的方法等。

  公开号：

  US20130157995A1

文献信息

• TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF
  申请人：Gangjee Aleem

  公开号：US20090062318A1

  公开（公告）日：2009-03-05

  The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase inhibitory activity, which are useful as anti-angiogenic and anti-tumor agents. Also provided are methods of utilizing these inhibitors to treat tumor cells and other proliferative diseases and disorders.

  本发明提供了一种三环化合物，其在单个分子中具有受体酪氨酸激酶、二氢叶酸还原酶、胸苷酸合成酶和/或二氢甲氧呋喃脱氢酶的抑制活性，这些化合物具有细胞静止和细胞毒活性，可用作抗血管生成和抗肿瘤药物。还提供了利用这些抑制剂治疗肿瘤细胞和其他增殖性疾病和紊乱的方法。
• OXYGEN-ABSORBING RESIN COMPOSITION, AND MULTILAYER BODY, CONTAINER, INJECTION-MOLDED BODY, AND MEDICAL CONTAINER USING SAME
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20150298887A1

  公开（公告）日：2015-10-22

  Provided are a novel oxygen-absorbing resin composition not responsive to a metal detector, producing no odor after absorption of oxygen and having excellent oxygen-absorbing performance, and a multilayer body, container, injection-molded article and medical container using these. Further provided are an oxygen-absorbing resin composition etc. having excellent oxygen-absorbing performance in a wide range of humidity conditions from low humidity to high humidity. The oxygen-absorbing resin composition of the present invention is an oxygen-absorbing resin composition containing a polyamide compound and a transition metal catalyst, wherein the polyamide compound has at least one constituent unit having a tetralin ring. Moreover, the multilayer body, container, injection-molded article, medical container, etc. of the present invention are obtained by using the oxygen-absorbing resin composition of the present invention.

  提供了一种新型的氧吸收树脂组合物，对金属探测器不敏感，在吸收氧气后不产生气味，具有出色的吸氧性能，以及使用这些的多层体、容器、注塑制品和医用容器。此外，还提供了一种氧吸收树脂组合物等，在从低湿度到高湿度的广泛湿度条件下具有出色的吸氧性能。本发明的氧吸收树脂组合物是一种含有聚酰胺化合物和过渡金属催化剂的氧吸收树脂组合物，其中聚酰胺化合物至少具有一个具有四氢萘环的组分单元。此外，本发明的多层体、容器、注塑制品、医用容器等是通过使用本发明的氧吸收树脂组合物获得的。
• Pyrimidine derivatives
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20030171359A1

  公开（公告）日：2003-09-11

  The present invention relates to trisubstituted pyrimidines of formula (I) 1 wherein 0R a to R e are defined as in claim 1, which are suitable for the treatment of illnesses characterised by excessive or abnormal cell proliferation, the use thereof for preparing a pharmaceutical composition with the abovementioned properties, and processes for the preparation thereof.

  本发明涉及式（I）的三取代嘧啶化合物，其中R至R如权利要求书中所定义，适用于治疗由细胞过度或异常增殖特征的疾病，其用于制备具有上述特性的药物组合物，以及其制备方法。
• Dendrimer based compositions and methods of using the same
  申请人：William Bernell

  公开号：US20070041934A1

  公开（公告）日：2007-02-22

  The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer based compositions and systems for use in disease diagnosis and therapy (e.g., cancer diagnosis and therapy). The compositions and systems comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and monitoring the response to therapy of a cell or tissue (e.g., a tumor).

  本发明涉及一种新型的治疗和诊断树状分子。具体而言，本发明涉及基于树状分子的组合物和系统，用于疾病诊断和治疗（例如癌症诊断和治疗）。该组合物和系统包括一种或多种用于靶向、成像、感知和/或提供治疗或诊断材料以及监测细胞或组织（例如肿瘤）对治疗的反应的组分。
• BENZYLATED MANNICH BASE CURING AGENTS, COMPOSITIONS, AND METHODS
  申请人：EVONIK DEGUSSA GMBH

  公开号：US20170240691A1

  公开（公告）日：2017-08-24

  Compositions and curing agents comprising a benzylated Mannich base composition. The benzylated Mannich base composition includes a reaction product of (a) a substituted phenolic compound having at least one substituent of formula (I): wherein R 1 is each independently a linear or branched alkyl group having 1 to 4 carbon atoms, and R 2 is hydrogen, methyl, ethyl or phenyl, with (b) a benzylated polyalkylene polyamine (II): wherein R A is substituted or unsubstituted benzyl; R B is each independently R A , or a hydrogen atom, or a group selected from C 1 -C 16 linear, cyclic, and branched alkyl, alkenyl, and alkaryl groups; X, Y, and Z are independently selected from C 2 -C 10 alkylene, and cycloalkylene groups; y is an integer from 0 to 7, and z is an integer from 0 to 4; and, optionally, (c) a multifunctional amine. Amine-epoxy compositions and articles produced from these compositions are also disclosed.

  含有苄基曼尼希碱基组分的组合物和固化剂。所述苄基曼尼希碱基组分包括以下反应产物：(a)至少具有一个取代基的取代酚化合物，所述取代基的公式为(I)：其中R1各自独立地是具有1到4个碳原子的线性或支链烷基，R2是氢、甲基、乙基或苯基；(b)苄基化的聚烯烃聚醚胺(II)：其中RA是取代或未取代的苄基，RB各自独立地是RA或氢原子，或选自C1-C16线性、环状和支链烷基、烯基和烷基芳基基团；X、Y和Z各自独立地选自C2-C10烷基和环状烷基基团；y是0到7的整数，z是0到4的整数；可选地，(c)多功能胺。还公开了胺-环氧组合物和由这些组合物制成的物品。