[3-(1-methylbutoxy)phenyl]amine | 27125-87-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [3-(1-methylbutoxy)phenyl]amine
• 英文别名: 3-(1-Methylbutoxy)anilin；[3-(1-Methylbutoxy)phenyl]amine；3-pentan-2-yloxyaniline
• CAS: 27125-87-7
• 化学式: C₁₁H₁₇NO
• mdl: MFCD20694315
• 分子量: 179.262
• InChiKey: QSQATXMXDDWAMH-UHFFFAOYSA-N

物化性质

• 沸点：
  292.1±13.0 °C(Predicted)
• 密度：
  0.984±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [3-(1-methylbutoxy)phenyl]amine 在 吡啶 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 2,2,2-trifluoro-N-[3-(1-methylbutoxy)phenyl]-N-(pyrimidin-5-ylmethyl)ethanesulfonamide
  参考文献：
  名称：

  Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

  摘要：

  Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure-activity-relationship investigations are discussed. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.07.079
• 作为产物：
  描述：

  4-chloropent-2-ene 在 Lindlar's catalyst 氢气 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 [3-(1-methylbutoxy)phenyl]amine
  参考文献：
  名称：

  Martynova,V.P. et al., Russian Journal of Organic Chemistry, 1970, vol. 6, p. 778 - 783

  摘要：

  DOI：

文献信息

• [EN] PIPERIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS<br/>[FR] DÉRIVÉS DE PIPÉRIDINE ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012001107A1

  公开（公告）日：2012-01-05

  The invention relates to new piperidine derivatives of the formula (I) to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  本发明涉及一种新的哌啶衍生物，其化学式为（I），以及它们作为药物的用途，它们的治疗用途的方法以及包含它们的制药组合物。
• Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors
  申请人：Hu H. Essa

  公开号：US20070287716A1

  公开（公告）日：2007-12-13

  The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.

  本发明涉及化合物，它们是代谢型谷氨酸受体的增强剂，包括mGluR2受体，可用于治疗或预防与谷氨酸功能障碍有关的神经和精神障碍以及代谢型谷氨酸受体参与的疾病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗代谢型谷氨酸受体参与的这种疾病中使用这些化合物和组合物。
• WO2006/49968
  申请人：——

  公开号：——

  公开（公告）日：——
• Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor
  作者：Essa Hu、Peter C. Chua、Lida Tehrani、Johnny Y. Nagasawa、Anthony B. Pinkerton、Blake A. Rowe、Jean-Michel Vernier、John H. Hutchinson、Nicholas D.P. Cosford

  DOI：10.1016/j.bmcl.2004.07.079

  日期：2004.10

  Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure-activity-relationship investigations are discussed. (C) 2004 Elsevier Ltd. All rights reserved.
• Martynova,V.P. et al., Russian Journal of Organic Chemistry, 1970, vol. 6, p. 778 - 783
  作者：Martynova,V.P. et al.

  DOI：——

  日期：——