2,4-Dimethoxy-6-phenylquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,4-Dimethoxy-6-phenylquinoline
• 化学式: C₁₇H₁₅NO₂
• 分子量: 265.312
• InChiKey: PPEZZSKVUAWSAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  31.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-溴-2,4-二氯喹啉 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 甲醇 、 乙醇 、 甲苯 为溶剂， 反应 96.0h， 生成 2,4-Dimethoxy-6-phenylquinoline
  参考文献：
  名称：

  Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes

  摘要：

  2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of H. contortus. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.044

文献信息

• [EN] ANTIPARASITIC COMPOUNDS<br/>[FR] COMPOSES ANTIPARASITES
  申请人：KING S COLLEGE LONDON

  公开号：WO2002026713A1

  公开（公告）日：2002-04-04

  Disclosed are antiparasitic compounds of Formulae (I, IA and IB). These compounds are useful in the manufacture of a pharmaceutical composition for the treatment or prophylaxis of infections caused by helminths or arthropod ectoparasites.
• Synthesis and anthelmintic properties of arylquinolines with activity against drug-resistant nematodes
  作者：Sharon Rossiter、Jean-Marie Péron、Philip J. Whitfield、Keith Jones

  DOI：10.1016/j.bmcl.2005.07.044

  日期：2005.11

  2,4-Disubstituted quinolines with additional substituents in positions 5-8 have been found to have anthelmintic properties. A number of 2,4-dimethoxy-6- or 8-arylquinolines have potent activity against the sheep nematode Haemonchus contortus, with LD99 values of the same order of magnitude as levamisole. These arylquinolines maintain their activity against levamisole-, ivermectin- and thiabendazole-resistant strains of H. contortus. (c) 2005 Elsevier Ltd. All rights reserved.